Abstract
Clinical signs and features include:
Malignant acanthosis nigricans, sign of Leser–Trélat, and tripe palms are often found together
Malignant acanthosis nigricans is rare: in total, worldwide, only 1,000 reported cases
Involves symmetric hyperpigmented plaques with variable amounts of epidermal hypertrophy, creating a velvety texture; ranges in color from yellow to gray/black; often has overlying scaling/papillomas (if extensive then cutaneous papillomatosis)
Progressive—generally advances with cancer, begins with increased pigmentation and advances to hypertrophy with accentuation of the skin lines; maybe associated with pruritus
Most commonly found on flexural areas, posterior neck, or mucosally (particularly the mouth)
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Reference
Moore RL, Devere TS. Epidermal manifestations of internal malignancy. Dermatol Clin. 2006;26:17–29.
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Zakko, L., Finch, J., Rothe, M.J., Grant-Kels, J.M. (2013). Malignant Acanthosis Nigricans, Sign of Leser–Trélat, and Tripe Palms. In: Wu, G., Selsky, N., Grant-Kels, J. (eds) Atlas of Dermatological Manifestations of Gastrointestinal Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6191-3_32
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DOI: https://doi.org/10.1007/978-1-4614-6191-3_32
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