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The Use of Isolated Heart Models and Anatomic Specimens as Means to Enhance the Design and Testing of Cardiac Valve Therapies

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Heart Valves

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Abstract

In recent years the use of perfusion-fixed cadaveric specimens and isolated heart models has helped develop an improved understanding of the device-tissue interface and contributed to the rapid evolution of surgically and percutaneously delivered valve therapies. This chapter describes a novel series of techniques utilized within the Visible Heart® laboratory by engineers, scientists, and anatomists to visualize and analyze the form and function of the four cardiac valves and assess potential repair or replacement therapies. The study of reanimated large mammalian hearts (including human) and specially prepared anatomical specimens using various clinical and nonclinical imaging modalities has provided feedback for both design engineers and clinicians that seek to develop and/or employ valve repair approaches for patients with acquired or congenital heart valve defects.

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Abbreviations

CT:

Computed tomography

MRI:

Magnetic resonance imaging

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Author information

Authors and Affiliations

  1. Departments of Surgery and Biomedical Engineering, University of Minnesota, 420 Delaware St. SE, MMC 195, Minneapolis, MN, 55455, USA

    Michael G. Bateman PhD & Christopher D. Rolfes PhD

  2. Cardiovascular, Medtronic, Inc., 8200 Coral Sea St. NE, Mounds View, MN, 55112, USA

    Alexander J. Hill PhD

  3. Department of Surgery, University of Minnesota, 420 Delaware St. SE, MMC 195, Minneapolis, MN, 55455, USA

    Alexander J. Hill PhD

  4. Medtronic, Inc., 8200 Coral Sea St. NE, Mounds View, MN, 55112, USA

    Jason L. Quill PhD & Michael D. Eggen PhD

  5. Department of Surgery, Institute for Engineering in Medicine, Lillehei Heart Institute, University of Minnesota, 420 Delaware St. SE., MMC 195, Minneapolis, MN, 55455, USA

    Paul A. Iaizzo PhD

Authors
  1. Michael G. Bateman PhD
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  2. Alexander J. Hill PhD
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  3. Jason L. Quill PhD
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  4. Michael D. Eggen PhD
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  5. Christopher D. Rolfes PhD
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  6. Paul A. Iaizzo PhD
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Corresponding author

Correspondence to Michael D. Eggen PhD .

Editor information

Editors and Affiliations

  1. , Mail Code 195, University of Minnesota, Delaware St. SE., 420, MINNEAPOLIS, 55455, Minnesota, USA

    Paul A. Iaizzo

  2. University of Minnesota, DELAWARE ST SE MMC 195 420, MINNEAPOLIS, 55455, Minnesota, USA

    Richard W. Bianco

  3. University of Minnesota, Department of Surgery, Medtronic, Inc., N/A, Minneapolis, 55432, Minnesota, USA

    Alexander J. Hill

  4. University of Minnesota, N/A, Minneapolis, 55455, Minnesota, USA

    James D. St. Louis

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Bateman, M.G., Hill, A.J., Quill, J.L., Eggen, M.D., Rolfes, C.D., Iaizzo, P.A. (2013). The Use of Isolated Heart Models and Anatomic Specimens as Means to Enhance the Design and Testing of Cardiac Valve Therapies. In: Iaizzo, P., Bianco, R., Hill, A., St. Louis, J. (eds) Heart Valves. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-6144-9_15

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