Abstract
Stem cell history started almost a century ago with administration of bone marrow by mouth to the patients with anemia and leukemia [1]. At that time, in the early 1900s, European scientists realized that all blood cells originate from one particular “stem cell” located within the bone marrow, tissue where the entire hematopoiesis take place. Early studies with animals quickly revealed that the bone marrow was the organ most sensitive to the damaging effects of radiation. Very soon, it became clear that reinfusion of marrow cells could rescue lethally irradiated animals. Mice with defective bone marrow could be restored to health with infusions into the blood stream of marrow taken from other mice [2].
The beginning is the most important part of the work.
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References
Li L, Xie T (2005) Stem cell niche: structure and function. Annu Rev Cell Dev Biol 17:605–631
He XC, Zhang J, Li L (2005) Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior. In: Stem cell biology: development and plasticity, vol 1049. Annals of the New York Academy of Sciences, New York, pp 28–38
Zhang J, Li L (2005) BMP signaling and stem cell regulation. Dev Biol 284:1–11
Li L (2005) Find the hematopoietic stem cell niche in placenta. Dev Cell 8:297–304
Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L (2004) Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt. Proc Natl Acad Sci USA 101(43):15370–15375
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L (2004) BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-atenin signaling. Nat Genet 36:1117–1121
Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harri S, Wiedemann LM, Mishina Y, Li L (2003) Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425:836–841
Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J, Li L (2003) Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 101(2):383–389
Park I, He Y, Lin F, Laerum O, Tian Q, Bumgarner R, Klug C, Li K, Kuhr C, Doyle M, Xie X, Schummer M, Sun Y, Goldsmith A, Clarke M, Weissman I, Hood L, Li L (2002) Differential gene expression profiling of adult murine hematopoietic stem cells. Blood 99:488–498
Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL (2001) From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci USA 98:7934–7939
Li L, Milner L, Deng Y, Iwata W, Banta A, Graf L, Marcovina S, Friedman C, Trask B, Hood L, Torok-Storb B (1998) The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity 8:43–55
Li L, Krantz ID, Deng Y, Genin A, Banta A, Collins C, Qi M, Trask BJ, Kuo W, Cochran J, Costa T, Pierpont MEM, Rand EB, Piccoli D, Hood L, Spinner N (1997) Alagille syndrome is caused by mutations in hJagged1 (JAG1), which encodes a ligand for Notch1. Nat Genet 16:243–251
Lee TC, Li L, Philipson L, Ziff EB (1997) Myc represses transcription of the growth arrest gene gas-1. Proc Natl Acad Sci USA 94:12886–12891
Li L, Nerlov C, Prendergast G, MacGregor D, Ziff EB (1994) c-Myc represses transcription by a novel mechanism dependent on the initiator element and Myc box II. EMBO J 13:4070–4079
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Pavlovic, M., Balint, B. (2013). Short History of Stem Cells Transplantation with Emphasis on Hematological Disorders. In: Stem Cells and Tissue Engineering. SpringerBriefs in Electrical and Computer Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5505-9_1
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DOI: https://doi.org/10.1007/978-1-4614-5505-9_1
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