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Generation of Histocompatible Tissues via Parthenogenesis

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The Immunological Barriers to Regenerative Medicine

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Parthenogenic stem (PS) cells are a potential source of histocompatible, pluripotent cells for transplantation therapy that does not rely on fertilized embryos. Parthenotes result from artificially activated oocytes that contain only maternal chromosomes, without contribution from sperm. Parthenotes cannot develop into live offspring, but have been used to derive PS cells in multiple species, including mouse and humans. Different oocyte activation protocols and natural recombination events may lead to PS cells that are heterozygous at the major histocompatibility complex (MHC) and therefore completely histocompatible to the oocyte donor, or MHC-homozygous and histocompatible to a significant percentage of the general population. Studies in mouse and nonhuman primates suggest the PS cells may be a valuable cell source for transplantation therapies, although further work is needed to establish the safety and efficacy of human PS cell based therapies.

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Authors and Affiliations

  1. Department of Biology, Northeastern University, Boston, MA, 02115, USA

    Paula W. Lampton & Judith A. Newmark

  2. Bedford Stem Cell Research Foundation and Harvard Medical School, Boston, MA, USA

    Ann A. Kiessling

Authors
  1. Paula W. Lampton
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  2. Judith A. Newmark
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  3. Ann A. Kiessling
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Correspondence to Paula W. Lampton .

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  1. Carlton Rd. 30, Oxford, OX2 7SB, United Kingdom

    Paul J. Fairchild

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Lampton, P.W., Newmark, J.A., Kiessling, A.A. (2013). Generation of Histocompatible Tissues via Parthenogenesis. In: Fairchild, P. (eds) The Immunological Barriers to Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5480-9_8

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