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Squamous Cell Carcinoma

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The Urinary Tract

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Abstract

In addition to urothelial carcinoma, adenocarcinoma, and small cell carcinoma, squamous cell carcinoma represents a major morphologic subtype of bladder cancer that harbors unique pathogenetic and molecular alterations. In the United States, squamous cell carcinoma affects less than 5 % of all bladder cancer patients, with primary risk factors that include tobacco smoke, long-term catheterization, urinary tract calculi, and a nonfunctioning bladder [1]. A male predominance is common (approximate 3:1 male:female ratio) and patients tend to be older (>60 years of age). Squamous cell carcinoma may also occur in the upper tract, with this form of carcinoma representing up to 10 % of all renal pelvis carcinomas and also likely incited by chronic inflammatory conditions [2–4]. In contrast to the bladder, upper tract squamous cell carcinoma tends to have a roughly equal proportion of men and women affected by the disease [3].

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Author information

Authors and Affiliations

  1. Department of Pathology, Cleveland Clinic, 9500 Euclid Avenue Desk L25, Cleveland, OH, 44195, USA

    Donna E. Hansel

  2. Sections of Oncology, Laparoscopy and Robotics, Cleveland Clinic, Glickman Urological and Kidney Institute, 9500 Euclid Avenue, Q10, Cleveland, OH, 44195, USA

    Amr Fergany

Authors
  1. Donna E. Hansel
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Correspondence to Donna E. Hansel .

Editor information

Editors and Affiliations

  1. Department of Pathology, Cleveland Clinic, Cleveland, 44195, Ohio, USA

    Donna E. Hansel

  2. Department of Pathology, Stanford University Medical Center, Stanford, 94305, California, USA

    Jesse K. McKenney

  3. Glickman Urologic and Kidney Institute, Section of Urologic Oncology, Cleveland Clinic, Cleveland, 44195, Ohio, USA

    Andrew J. Stephenson

  4. Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, 37232-2765, Tennessee, USA

    Sam S. Chang

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Hansel, D.E., Fergany, A. (2012). Squamous Cell Carcinoma. In: Hansel, D., McKenney, J., Stephenson, A., Chang, S. (eds) The Urinary Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5320-8_10

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  • DOI: https://doi.org/10.1007/978-1-4614-5320-8_10

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-5319-2

  • Online ISBN: 978-1-4614-5320-8

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