Abstract
Among the eight filarial species of humans (Table 7.1), three closely related parasitic nematodes (Wuchereria bancrofti, Brugia malayi, and Brugia timori) cause lymphatic filariasis (LF). Unlike most other helminthiases, the burden of infection and disease in lymphatic filariasis occurs primarily during adulthood where the cumulative effects of chronicity and infection intensity manifest themselves.
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References
Mathers CD, Ezzati M, Lopez AD (2007) Measuring the burden of neglected tropical diseases: the global burden of disease framework. PLoS Negl Trop Dis 1(2):e114
Haddix AC, Kestler A (2000) Lymphatic filariasis: economic aspects of the disease and programmes for its elimination. Trans R Soc Trop Med Hyg 94(6):592–593
Ottesen EA (2006) Lymphatic filariasis: treatment, control and elimination. Adv Parasitol 61:395–441
WHO (2011) Meeting of the international task force for disease eradication – October 2010. Wkly Epidemiol Rec 86(7):53–59
Bockarie M et al (1996) Transmission dynamics of Wuchereria bancrofti in East Sepik Province, Papua New Guinea. Am J Trop Med Hyg 54(6):577–581
Sasa M (1976) Human filariasis. University Park Press, Baltimore, pp 1–819
Kazura JW et al (1997) Transmission intensity and its relationship to infection and disease due to Wuchereria bancrofti in Papua New Guinea. J Infect Dis 176(1):242–246
Routh HB, Bhowmik KR (1993) History of elephantiasis. Int J Dermatol 32(12):913–916
Rajan TV (2000) Lymphatic filariasis: a historical perspective. In: Nutman TB (ed) Lymphatic filariasis, vol 1. Imperial College Press, London, pp 1–4
Demarquay J-N (1863) Helminthologie. Gazette Medicale de Paris 18:665–667
Wucherer OEH (1868) Noticia preliminar sobrevermes de uma especie ainda nao descripta, encontrados na urina de donentes de hematuria intertropical no Brazil. Gazetas Medica de Bahia 3:97–99
Lewis TR (1872) On a hematozoan inhabiting human blood, its relation to chyluria and other diseases. In: Microscopic organisms found in the blood of man an animals and its relationship to disease. Office of the Superintendent of the Sanitary Commissioner with the Government of India, Calcutta, pp 75–79
Manson P (1899) On filarial periodicity. Br Med J 2:644–646
Manson P (1884) Further observations on filaria sanguinis hominis in an epitome of the reports of the medical officers to the China imperial maritime customs, from 1871–1882. Balliere, Tindall and Cox., London, pp 203–206
Cobbold TS (1877) Discovery of the adult representative of a microscopic Filariae. Lancet 2:70–71
Bourne AG (1888) A note on filaria Filaria Sanguinis Hominis (with description of a male specimen). Br Med J 1:1050–1051
Bancroft TL (1899) On the metamorphosis of the young form of Filaria bancrofti Cobbold (Filaria sanguinis hominis Lewis; Filaria nocturna Manson) in the body of Culex ciliaris, the house mosquito of Australia. J Trop Med 2:91–94
Low GC (1900) A recent observation on Filaria nocturna in Culex; probable mode of infection of man. Br Med J 1:1456–1457
Buckley JJ (1960) On Brugia gen. nov. for Wuchereria spp. of the inverted question markmalayl’ group, i.e., W. malayi (Brug, 1927), W. pahangi Buckley and Edeson, 1956, and W. patei Buckley, Nelson and Heisch, 1958. Ann Trop Med Parasitol 54:75–77
O’Connor FW (1931) Filarial periodicity with observations and on the mechanisms of migration of the microfilariae and from parent worm to the blood stream. PR Public Health Trop Med 6:263
Kozek WJ, Marroquin HF (1977) Intracytoplasmic bacteria in Onchocerca volvulus. Am J Trop Med Hyg 26(4):663–678
McLaren DJ et al (1975) Micro-organisms in filarial larvae (Nematoda). Trans R Soc Trop Med Hyg 69(5–6):509–514
Sironi M et al (1995) Molecular evidence for a close relative of the arthropod endosymbiont Wolbachia in a filarial worm. Mol Biochem Parasitol 74(2):223–227
Taylor MJ, Hoerauf A (1999) Wolbachia bacteria of filarial nematodes. Parasitol Today 15(11):437–442
Hise AG, Gillette-Ferguson I, Pearlman E (2004) The role of endosymbiotic Wolbachia bacteria in filarial disease. Cell Microbiol 6(2):97–104
Rajan TV (2004) Relationship of anti-microbial activity of tetracyclines to their ability to block the l3 to L4 molt of the human filarial parasite Brugia malayi. Am J Trop Med Hyg 71(1):24–28
Mand S et al (2009) Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine. Am J Trop Med Hyg 81(4):702–711
Taylor MJ et al (2005) Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet 365(9477):2116–2121
Supali T et al (2008) Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment. Clin Infect Dis 46(9):1385–1393
Ottesen EA (1992) Infection and disease in lymphatic filariasis – an immunological perspective. Parasitology 104:571
Dreyer G et al (1992) Renal abnormalities in microfilaremic patients with Bancroftian filariasis. Am J Trop Med Hyg 46(6):745–751
Freedman DO et al (1994) Lymphoscintigraphic analysis of lymphatic abnormalities in symptomatic and asymptomatic human filariasis. J Infect Dis 170(4):927–933
Case T et al (1991) Vascular abnormalities in experimental and human lymphatic filariasis. Lymphology 24(4):174–183
Witte MH et al (1993) Lymphatic abnormalities in human filariasis as depicted by lymphangioscintigraphy. Arch Intern Med 153(6):737–744
Mand S et al (2003) Animated documentation of the filaria dance sign (FDS) in bancroftian filariasis. Filaria J 2(1):3
Noroes J et al (1996) Ultrasonographic evidence of abnormal lymphatic vessels in young men with adult Wuchereria bancrofti infection in the scrotal area. J Urol 156(2 Pt 1):409–412
Noroes J et al (1996) Occurrence of living adult Wuchereria bancrofti in the scrotal area of men with microfilaraemia. Trans R Soc Trop Med Hyg 90(1):55–56
Dreyer G et al (2000) Pathogenesis of lymphatic disease in bancroftian filariasis: a clinical perspective. Parasitol Today 16(12):544–548
Aguiar-Santos AM et al (2009) Lymph scrotum: an unusual urological presentation of lymphatic filariasis. A case series study. Rev Inst Med Trop Sao Paulo 51(4):179–183
Addiss DG, Brady MA (2007) Morbidity management in the Global Programme to Eliminate Lymphatic Filariasis: a review of the scientific literature. Filaria J 6:2
Dreyer G et al (1999) Acute attacks in the extremities of persons living in an area endemic for bancroftian filariasis: differentiation of two syndromes. Trans R Soc Trop Med Hyg 93(4):413–417
WHO (1984) Lymphatic filariasis. Fourth report of the WHO Expert Committee on Filariasis. World Health Organ Tech Rep Ser 702:3–112
Dreyer G et al (2002) Basic lymphoedema management: treatment and prevention of problems associated with lymphatic filariasis. Hollis Publishing Co, Hollis, p 112
Dreyer G, Mattos D, Noroes J (2007) Chyluria. Rev Assoc Med Bras 53(5):460–464
Ottesen EA, Nutman TB (1992) Tropical pulmonary eosinophilia. Annu Rev Med 43:417–424
Coutinho AD et al (1998) Tropical filarial pulmonary eosinophilia and its differential diagnosis. Rev Hosp Clin Fac Med Sao Paulo 53(1):42–51
Rom WN et al (1990) Persistent lower respiratory tract inflammation associated with interstitial lung disease in patients with tropical pulmonary eosinophilia following conventional treatment with diethylcarbamazine. Am Rev Respir Dis 142(5):1088–1092
El Setouhy M et al (2004) A randomized clinical trial comparing single- and multi-dose combination therapy with diethylcarbamazine and albendazole for treatment of bancroftian filariasis. Am J Trop Med Hyg 70(2):191–196
Horton J et al (2000) An analysis of the safety of the single dose, two drug regimens used in programmes to eliminate lymphatic filariasis. Parasitology 121(Suppl):S147–S160
Molyneux DH et al (2003) Mass drug treatment for lymphatic filariasis and onchocerciasis. Trends Parasitol 19(11):516–522
Ottesen EA (2002) Major progress toward eliminating lymphatic filariasis. N Engl J Med 347(23):1885–1886
Addiss D, et al (2004) Albendazole for lymphatic filariasis. Cochrane Database Syst Rev (1): CD003753
Jamal S (1981) Lymphovenous anastomosis in filarial lymphedema. Lymphology 14(2):64–68
Ottesen EA et al (1997) Strategies and tools for the control/elimination of lymphatic filariasis. Bull World Health Organ 75(6):491–503
Molyneux DH, Zagaria N (2002) Lymphatic filariasis elimination: progress in global programme development. Ann Trop Med Parasitol 96(Suppl 2):S15–S40
Ottesen EA et al (2008) The global programme to eliminate lymphatic filariasis: health impact after 8 years. PLoS Negl Trop Dis 2(10):e317
Bockarie MJ, Molyneux DH (2009) The end of lymphatic filariasis? BMJ 338:b1686
Molyneux D (2003) Lymphatic filariasis (elephantiasis) elimination: a public health success and development opportunity. Filaria J 2(1):13
Addiss DG (2010) Global elimination of lymphatic filariasis: addressing the public health problem. PLoS Negl Trop Dis 4(6):e741
Schneider MC et al (2011) Elimination of neglected diseases in latin america and the Caribbean: a mapping of selected diseases. PLoS Negl Trop Dis 5(2):e964
Ramaiah KD et al (2011) Effect of annual mass administration of diethylcarbamazine and albendazole on bancroftian filariasis in five villages in south India. Trans R Soc Trop Med Hyg 105(8):431–437
Hoerauf A et al (2011) Filariasis in Africa-treatment challenges and prospects. Clin Microbiol Infect 17(7):977–985
Simonsen PE et al (2010) Lymphatic filariasis control in Tanzania: effect of repeated mass drug administration with ivermectin and albendazole on infection and transmission. PLoS Negl Trop Dis 4(6):e696
Gyapong JO et al (2010) Integration of control of neglected tropical diseases into health-care systems: challenges and opportunities. Lancet 375(9709):160–165
Bockarie MJ, Deb RM (2010) Elimination of lymphatic filariasis: do we have the drugs to complete the job? Curr Opin Infect Dis 23(6):617–620
Brady MA, Hooper PJ, Ottesen EA (2006) Projected benefits from integrating NTD programs in sub-Saharan Africa. Trends Parasitol 22(7):285–291
Smits HL (2009) Prospects for the control of neglected tropical diseases by mass drug administration. Expert Rev Anti Infect Ther 7(1):37–56
Blackburn BG et al (2006) Successful integration of insecticide-treated bed net distribution with mass drug administration in Central Nigeria. Am J Trop Med Hyg 75(4):650–655
Richards FO Jr et al (2006) Integration of mass drug administration programmes in Nigeria: the challenge of schistosomiasis. Bull World Health Organ 84(8):673–676
Haddad D et al (2008) Health care at the end of the road: opportunities from 20 years of partnership in onchocerciasis control. Glob Public Health 3(2):187–196
Tadesse Z, Hailemariam A, Kolaczinski JH (2008) Potential for integrated control of neglected tropical diseases in Ethiopia. Trans R Soc Trop Med Hyg 102(3):213–214
Matthews GA et al (2009) Preliminary examination of integrated vector management in a tropical rainforest area of Cameroon. Trans R Soc Trop Med Hyg 103(11):1098–1104
Addiss D (2010) The 6th Meeting of the Global Alliance to Eliminate Lymphatic Filariasis: a half-time review of lymphatic filariasis elimination and its integration with the control of other neglected tropical diseases. Parasit Vectors 3(1):100
Shriram AN et al (2011) Diurnally subperiodic filariasis in India-prospects of elimination: precept to action? Parasitol Res 109(1):1–8
Bhullar N, Maikere J (2010) Challenges in mass drug administration for treating lymphatic filariasis in Papua, Indonesia. Parasit Vectors 3:70
Ramaiah KD (2009) Lymphatic filariasis elimination programme in India: progress and challenges. Trends Parasitol 25(1):7–8
Bockarie MJ, Taylor MJ, Gyapong JO (2009) Current practices in the management of lymphatic filariasis. Expert Rev Anti Infect Ther 7(5):595–605
Streit T, Lafontant JG (2008) Eliminating lymphatic filariasis: a view from the field. Ann N Y Acad Sci 1136:53–63
Pedersen EM et al (2009) The role of monitoring mosquito infection in the Global Programme to Eliminate Lymphatic Filariasis. Trends Parasitol 25(7):319–327
Stolk WA, de Vlas SJ, Habbema JD (2006) Advances and challenges in predicting the impact of lymphatic filariasis elimination programmes by mathematical modelling. Filaria J 5:5
Hooper PJ et al (2009) The Global Programme to Eliminate Lymphatic Filariasis: health impact during its first 8 years (2000–2007). Ann Trop Med Parasitol 103(Suppl 1):S17–S21
Chu BK et al (2010) The economic benefits resulting from the first 8 years of the Global Programme to Eliminate Lymphatic Filariasis (2000–2007). PLoS Negl Trop Dis 4(6):e708
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Nutman, T.B. (2013). Lymphatic Filariasis: Progress and Challenges in the Move Toward Elimination. In: Fong, I. (eds) Challenges in Infectious Diseases. Emerging Infectious Diseases of the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4496-1_7
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