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Rodent Models of Tremor

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Mechanisms and Emerging Therapies in Tremor Disorders

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Tremor is a rhythmical, involuntary, oscillatory movement of a body part, and it is one of the most frequently encountered abnormal involuntary movements. Tremor is a principal symptom of neurological disorders such as essential tremor, Parkinson’s disease, and related disorders. Unfortunately, the actual pathophysiological mechanisms underlying tremor remain poorly understood, and thus no effective therapeutic strategies have been developed. The creation and analysis of animal models for tremor (Martin et al. 2005) allow a better understanding of the tremor-generating mechanisms. This chapter reviews the animal models of tremor, particularly those induced by pharmacological agents in rodents.

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Acknowledgment

We gratefully acknowledge Ms. Tomomi Kubo and Mrs. Ai Suzuki for technical assistance.

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Authors and Affiliations

  1. Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama-city, Wakayama, 641-8510, Japan

    Hideto Miwa M.D.

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  1. Hideto Miwa M.D.
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Correspondence to Hideto Miwa M.D. .

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Editors and Affiliations

  1. , Unité d'Etude due Mouvement (UEM), Neurologie ULB Erasme, N/A, Bruxelles, N/A, Belgium

    Giuliana Grimaldi

  2. route de Lennik 808, Bruxelles, 1070, Belgium

    Mario Manto

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Miwa, H. (2013). Rodent Models of Tremor. In: Grimaldi, G., Manto, M. (eds) Mechanisms and Emerging Therapies in Tremor Disorders. Contemporary Clinical Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4027-7_3

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