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Clock Genes and Energy Metabolism

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Sleep Loss and Obesity

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Abstract

Circadian timekeeping is a ubiquitous feature of all eukaryotes and allows appropriate temporal regulation of an organism’s physiology, behavior, and metabolism to anticipate and respond to recurrent daily changes in the environment. Animal models provide strong evidence that disruption of circadian pathways are associated with metabolic dysregulation and sleep-related pathologies, while high-fat feeding reveals disrupted circadian rhythms of feeding, activity, and sleep. In humans, short sleep duration is associated with increased risk of metabolic syndrome, including obesity, diabetes, ­cardiovascular diseases, and cancer. Here, we examine emerging insight into how the circadian clock network influences energy metabolism.

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Acknowledgments

The authors wish to thank A. Wicher for administrative assistance. J. Bass is supported by NIH grants R01 DK090625 and P01 AG011412, the Chicago Biomedical Consortium with support from the Searle Funds at the Chicago Community Trust, and the University of Chicago Diabetes Research and Training Center ­(DK-20595).

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Authors and Affiliations

  1. Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Lurie 7-105, Chicago, IL, 60611, USA

    Hee-Kyung Hong

  2. Department of Medicine, Division of Endocrinology, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Lurie 7-105, Chicago, IL, 60611, USA

    Wenyu Huang, Kathryn Moynihan Ramsey, Biliana Marcheva & Joseph Bass

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  1. Hee-Kyung Hong
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Correspondence to Joseph Bass .

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Editors and Affiliations

  1. , Division of Sleep Medicine, Harvard Medical School, 1400 VFW Parkway, West Roxbury, 02132, USA

    Priyattam Shiromani

  2. , Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave., New Haven, 06519, USA

    Tamas Horvath

  3. , Department of Medicine, Harvard Medical School, Brigham and Wome, 221 Longwood Ave., Boston, 02115, USA

    Susan Redline

  4. , Department of Medicine, The University of Chicago, 5841 S. Maryland Avenue, Chicago, 60637, USA

    Eve Van Cauter

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Hong, HK., Huang, W., Ramsey, K.M., Marcheva, B., Bass, J. (2012). Clock Genes and Energy Metabolism. In: Shiromani, P., Horvath, T., Redline, S., Van Cauter, E. (eds) Sleep Loss and Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3492-4_2

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