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Regeneration-Associated Genes on Optic Nerve Regeneration in Fish Retina

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 801))

Abstract

It has been well documented that fish central nervous system, including retina and optic nerve, can regenerate and recover its function after nerve injury. Within a few decades, a number of regeneration-associated genes (RAGs) have been identified in fish retina following optic nerve injury (ONI). RAGs can be classified into two groups: cell survival- and axonal outgrowth-related genes. In fish retina after ONI, cell survival-related genes were upregulated in 1–6 days after ONI, which corresponds to the preparation stage for cell survival and axonal sprouting. Subsequently, axonal outgrowth-related genes were upregulated in 1–6 weeks after ONI, which corresponds to the axonal regrowth stage. Recently, we’ve found a novel type of RAGs, dedifferentiation-related genes, that are upregulated in overlapping time between cell survival and axonal regrowth (3–10 days after ONI). In this chapter we summarize these three types of RAGs that promote optic nerve regeneration in the fish retina after ONI.

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Abbreviations

Dpi:

Day(s) post-injury

FXIII-A:

Cellular factor XIII A subunit

GAP43:

Growth associated protein 43

IGF-1:

Insulin-like growth factor 1

NO:

Nitric oxide

NOS:

Nitric oxide synthase

ONI:

Optic nerve injury

PI3K:

Phosphatidylinositol-3 kinase

RAG:

Regeneration-associated gene

RGC:

Retinal ganglion cell

TGR :

Retinal transglutaminase

References

  1. Ramón y Cajal S (1928) Degeneration and regeneration in the nervous system. Haffner Publishing Co, New York

    Google Scholar 

  2. Matsukawa T, Arai K, Koriyama Y, Liu Z, Kato S (2004) Axonal regeneration of fish optic nerve after injury. Biol Pharm Bull 27:445–451

    Article  PubMed  CAS  Google Scholar 

  3. Homma K, Koriyama Y, Mawatari K, Higuchi Y, Kosaka J, Kato S (2007) Early downregulation of IGF-I decides the fate of rat retinal ganglion cells after optic nerve injury. Neurochem Int 50:741–748

    Article  PubMed  CAS  Google Scholar 

  4. Koriyama Y, Homma K, Sugitani K, Higuchi Y, Matsukawa T, Murayama D, Kato S (2007) Upregulation of IGF-I in the goldfish retinal ganglion cells during the early stage of optic nerve regeneration. Neurochem Int 50:749–756

    Article  PubMed  CAS  Google Scholar 

  5. Nagashima M, Fujikawa C, Mawatari K, Mori Y, Kato S (2012) HSP70, the earliest-induced gene in the zebrafish retina during optic nerve regeneration: its role in cell survival. Neurochem Int 58:888–895

    Article  CAS  Google Scholar 

  6. Koeberle PD, Ball AK (1999) Nitric oxide synthase inhibition delays axonal degeneration and promotes the survival of axotomized retinal ganglion cells. Exp Neurol 158:366–381

    Article  PubMed  CAS  Google Scholar 

  7. Goureau O, Régnier-Ricard F, Courtois Y (1999) Requirement for nitric oxide in retinal neuronal cell death induced by activated Müller glial cells. J Neurochem 72:2506–2515

    Article  PubMed  CAS  Google Scholar 

  8. Leon S, Yin Y, Nguyen J, Irwin N, Benowitz LI (2000) Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci 20:4615–4626

    PubMed  CAS  Google Scholar 

  9. Kaneda M, Nagashima M, Nunome T, Muramatsu T, Yamada Y, Kubo M, Muramoto K, Matsukawa T, Koriyama Y, Sugitani K, Vachkov IH, Mawatari K, Kato S (2008) Changes of phospho-growth-associated protein 43 (phospho-GAP43) in the zebrafish retina after optic nerve injury: a long-term observation. Neurosci Res 61:281–288

    Article  PubMed  CAS  Google Scholar 

  10. Tanaka M, Murayama D, Nagashima M, Higashi T, Mawatari K, Matsukawa T, Kato S (2007) Purpurin expression in the zebrafish retina during early development and after optic nerve lesion in adults. Brain Res 1153:34–42

    Article  PubMed  CAS  Google Scholar 

  11. Nagashima M, Sakurai H, Mawatari K, Koriyama Y, Matsukawa T, Kato S (2008) Involvement of retinoic acid signaling in goldfish optic nerve regeneration. Neurochem Int 54:229–236

    Article  PubMed  CAS  Google Scholar 

  12. Nagashima M, Mawatari K, Tanaka M, Higashi T, Saito H, Muramoto K, Matsukawa T, Koriyama Y, Sugitani K, Kato S (2009) Purpurin is a key molecule for cell differentiation during the early development of zebrafish retina. Brain Res 1302:54–63

    Article  PubMed  CAS  Google Scholar 

  13. Skene JH (1989) Axonal growth-associated proteins. Annu Rev Neurosci 12:127–156

    Article  PubMed  CAS  Google Scholar 

  14. Coggins PJ, Zwiers H (1989) Evidence for a single protein kinase C-mediated phosphorylation site in rat brain protein B-50. J Neurochem 53:1895–1901

    Article  PubMed  CAS  Google Scholar 

  15. Sugitani K, Matsukawa T, Koriyama Y, Shintani T, Nakamura T, Noda M, Kato S (2006) Upregulation of retinal transglutaminase during the axonal elongation stage of goldfish optic nerve regeneration. Neuroscience 142:1081–1092

    Article  PubMed  CAS  Google Scholar 

  16. Sugitani K, Ogai K, Hitomi K, Nakamura-Yonehara K, Shintani T, Noda M, Koriyama Y, Tanii H, Matsukawa T, Kato S (2012) A distinct effect of transient and sustained upregulation of cellular factor XIII in the goldfish retina and optic nerve on optic nerve regeneration. Neurochem Int 61:423–432

    Article  PubMed  CAS  Google Scholar 

  17. Thummel R, Kassen SC, Enright JM, Nelson CM, Montgomery JE, Hyde DR (2008) Characterization of Müller glia and neuronal progenitors during adult zebrafish retinal regeneration. Exp Eye Res 87:433–444

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  18. Lendahl U, Zimmerman LB, McKay RD (1990) CNS stem cells express a new class of intermediate filament protein. Cell 60:585–595

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, 920-0942, Kanazawa, Ishikawa, Japan

    Kazuhiro Ogai, Maki Nishitani, Ayaka Kuwana, Kazuhiro Mawatari, Kayo Sugitani & Hiroshi Nakashima

  2. Department of Molecular Neurobiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan

    Yoshiki Koriyama & Satoru Kato

Authors
  1. Kazuhiro Ogai
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  2. Maki Nishitani
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  3. Ayaka Kuwana
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  4. Kazuhiro Mawatari
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  5. Yoshiki Koriyama
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  6. Kayo Sugitani
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  7. Hiroshi Nakashima
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  8. Satoru Kato
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Corresponding author

Correspondence to Satoru Kato .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Florida, Gainesville, Florida, USA

    John D. Ash

  2. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  3. Cole Eye Institute at the Cleveland Clin Division of Ophthalmology, Cleveland, Ohio, USA

    Joe G. Hollyfield

  4. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  5. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  6. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

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© 2014 Springer Science+Business Media, LLC

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Ogai, K. et al. (2014). Regeneration-Associated Genes on Optic Nerve Regeneration in Fish Retina. In: Ash, J., Grimm, C., Hollyfield, J., Anderson, R., LaVail, M., Bowes Rickman, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 801. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3209-8_56

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  • DOI: https://doi.org/10.1007/978-1-4614-3209-8_56

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-3208-1

  • Online ISBN: 978-1-4614-3209-8

  • eBook Packages: MedicineMedicine (R0)

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