Abstract
Tuberculosis is the most common bacterial infection in the world with approximately two billion people infected (one-third of the world’s population). Treatment of tuberculosis dates back to the discovery that isoniazid (INH), a compound discovered in 1912 and found to be effective in treatment of TB in the 1950s. It is still the most commonly used agent, and with rifampin, a part of all first-line regimens. While INH is still recommended for initial therapy in most cases, resistance to INH has been reported, and therefore initial therapy always involves multiple drugs.
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Further Reading
Sia, I. G., & Wieland, M. L. (2011). Current concepts in the management of tuberculosis. Mayo Clin Proc, 86(4), 348–361.
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Finberg, R.W., Guharoy, R. (2012). Clinical Approach to Treatment of Mycobacterial Infections. In: Clinical Use of Anti-infective Agents. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1068-3_18
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DOI: https://doi.org/10.1007/978-1-4614-1068-3_18
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