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Silver Containing Biomaterials

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Biomaterials Associated Infection

Abstract

Despite considerable research and development efforts, the problem of infections related to biomedical devices and implants persists. Silver has attracted considerable interest for its ability to mitigate bacterial colonization of biomaterials surfaces in vitro and has been used in some commercial products such as wound bandages. Silver ion releasing biomaterials are thus considered to be promising candidates for rendering surfaces of biomedical devices and implants resistant to bacterial attachment. Here we review a number of strategies used for the design of antibacterial coatings containing silver. We also discuss the continuing controversy regarding the potential for silver ions to exert adverse effects on human cells and tissue. Finally we briefly compare the silver release approach with the alternative strategy of antibacterial coatings comprising organic antibiotics covalently coupled onto biomaterials surfaces.

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Acknowledgments

This work was supported in part by the Australian Government under NHMRC grant 1000737. KV acknowledges the Australian Research Council for support through fellowship FT100100292.

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Authors and Affiliations

  1. Ian Wark Research Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia

    Neil Poulter, Stefani S. Griesser & Hans J. Griesser

  2. Mawson Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia

    Neil Poulter, Krasimir Vasilev & Stefani S. Griesser

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  1. Neil Poulter
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  2. Krasimir Vasilev
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  3. Stefani S. Griesser
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  4. Hans J. Griesser
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Correspondence to Hans J. Griesser .

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Editors and Affiliations

  1. AO Research Institute Davos, Clavadelerstrasse 8, Davos Platz, 7270, Switzerland

    T. Fintan Moriarty

  2. , Medical Microbiology, Academic Medical Center, Meibergdreef 15, Amsterdam, 1105 AZ, Netherlands

    Sebastian A.J. Zaat

  3. University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713 AV, Netherlands

    Henk J. Busscher

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Poulter, N., Vasilev, K., Griesser, S.S., Griesser, H.J. (2013). Silver Containing Biomaterials. In: Moriarty, T., Zaat, S., Busscher, H. (eds) Biomaterials Associated Infection. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1031-7_14

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