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Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy

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Insulin-like Growth Factors and Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The insulin-like growth factor-I receptor (IGF-IR) is present in many types of tumor cells. Additionally, some tumors show upregulation of IGF-IR number or constitutive activation. There is a great deal of interest in determining whether drugs that target the IGF receptors, such as anti-IGF-IR antibodies, can inhibit tumor cell proliferation or induce tumor cell apoptosis. The studies in cells in culture and those conducted using xenografts of tumors in animals have shown that anti-IGF-IR antibodies are very effective in inhibiting tumor cell growth. The initial human trials have not shown definitive evidence of tumor shrinkage in a large number of patients; however, subsets of patients particularly those with sarcomas have shown some responsiveness. Current studies are seeking to determine whether administration of this antibody in combination with traditional chemotherapy and/or other antibodies targeting other types of growth factor receptors can lead to improved responses. Additionally, targeting downstream signaling elements in conjunction with the IGF-IR is also being utilized as an alternative approach. The larger trials that are ongoing are likely to resolve these issues and determine the ultimate efficacy of this agent in cancer chemotherapy. This chapter focuses on antibodies directed toward the IGF-1R. The use of tyrosine kinase inhibitors as an alternative approach is discussed elsewhere in this book.

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  1. Division of Endocrinology, University of North Carolina, School of Medicine, Burnett-Womack, Chapel Hill, NC, USA

    David R. Clemmons

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Correspondence to David R. Clemmons .

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  1. , Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, NEW YORK, 10029, USA

    Derek LeRoith

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Clemmons, D.R. (2012). Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy. In: LeRoith, D. (eds) Insulin-like Growth Factors and Cancer. Cancer Drug Discovery and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0598-6_10

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