Abstract
The gastrointestinal tract is a tube that extends from the end of the pharynx to the anus. Its functions are the propulsion and digestion of food and the elimination of the waste products. It is divided into primary segments that are, from rostral to caudal, the esophagus, stomach, small intestine, and large intestine. The primary segments are divided into secondary segments and are, from rostral to caudal: the proximal, middle and distal parts of the esophagus; the cardia, fundus, body, and antrum or pylorus of the stomach; the duodenum (with its first, second, third, and fourth parts), jejunum and ileum of the small intestine; and the cecum, appendix, ascending, transverse, descending, sigmoid, rectum, and anal canal segments of the large intestine. The histologic junctions between the primary segments may be abrupt but those between the secondary segments are gradual transition zones. Sphincters and valves at junctions of primary segments regulate forward propulsion and prevent retrograde flow of the contents. Although the general architecture of the gastrointestinal tract is established in embryonic life, there is continued development of the layers of the wall during fetal life. Thus, the histology of the gastrointestinal tract is characterized by numerous changes in the fetal period, which are highlighted in this chapter.
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References
O’Rahilly R: The timing and sequence of events in the development of the human digestive system and associated structures during the embryonic period proper. Anat Embryol (Berl) 1978, 153:123–136.
Lewis F: The early development of the entodermal tract and the formation of its subdivisions. In Human Embryology. Edited by Keibel F, Mall FP. Philadelphia: J. B. Lippincott; 1912:295–334.
O’Rahilly R, Muller F: Developmental Stages In Human Embryos. Washington DC: The Carnegie Institution of Washington; 1987.
Sembra R, Tanaka O, Tanimura T: The digestive tract. In Atlas of Prenatal Histology. Edited by Nishimura H. Tokyo: Igaku-Shoin; 1983:193–225.
Moxey PC, Trier JS: Endocrine cells in the human fetal small intestine. Cell Tissue Res 1977, 183:33–50.
Sjolund K, Sanden G, Hakanson R, Sundler F: Endocrine cells in human intestine: an immunocytochemical study. Gastroenterology 1983, 85:1120–1130.
Lewis F: The development of the esophagus. In Human Embryology. Edited by Keibel F, Mall FP. Philadelphia: J. B. Lippincott; 1912:355–368.
Lewis F: Development of the stomach. In Human Embryology. Edited by Keibel F, Mall FP. Philadelphia: J. B. Lippincott; 1912:368–381.
Lewis F: Development of the small intestine. In Human Embryology. Edited by Keibel F, Mall FP. Philadelphia: J. B. Lippincott Company; 1912:381–393.
Lewis F: Development of the large intestine. In Human Embryology. Edited by Keibel F, Mall FP. Philadelphia: J. B. Lippincott Company; 1912:393–399.
Huff D: Developmental anatomy and anomalies of the gastrointestinal tract, with involvement in major malformative syndromes. In Pathology of Pediatric Gastrointestinal and Liver Disease. Edited by Russo P, Ruchelli E, Piccoli DA. New York: Springer; 2004:3–36.
O’Rahilly R, Muller F: Human Embryology & Teratology, edn 3. New York: Wiley-Liss; 2001.
Fu M, Tam PK, Sham MH, Lui VC: Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: a topographical study. Anat Embryol (Berl) 2004, 208:33–41.
Wallace AS, Burns AJ: Development of the enteric nervous system, smooth muscle and interstitial cells of Cajal in the human gastrointestinal tract. Cell Tissue Res 2005, 319:367–382.
Spencer J, MacDonald TT, Finn T, Isaacson PG: The development of gut associated lymphoid tissue in the terminal ileum of fetal human intestine. Clin Exp Immunol 1986, 64:536–543.
Otani H, Yoneyama T, Hashimoto R, et al.: Ultrastructure of the developing stomach in human embryos. Anat Embryol (Berl) 1993, 187:145–151.
Zhou H, Greco MA, Daum F, Kahn E: Origin of cardiac mucosa: ontogenic consideration. Pediatr Dev Pathol 2001, 4:358–363.
De Hertogh G, Van Eyken P, Ectors N, Geboes K: On the origin of cardiac mucosa: a histological and immunohistochemical study of cytokeratin expression patterns in the developing esophagogastric junction region and stomach. World J Gastroenterol 2005,11:4490–4496.
Dikov DI, Auriault ML, Boivin JF, et al.: Hyaline globules (thanatosomes) in gastrointestinal epithelium: pathophysiologic correlations. Am J Clin Pathol 2007, 127:792–799.
Kobayashi S, Iwanaga T, Fujita T: Segi’s cap: huge aggregation of basal-granulated cells discovered by Segi (1935) on the intestinal villi of the human fetus. Arch Histol Jpn 1980, 43:79–83.
Acknowledgment
The author thanks Dr. Tricia R. Bhatti from The Children’s Hospital of Philadelphia, Philadelphia, PA, for invaluable assistance in selecting microscopic slides for photography, taking photographs, and editing the manuscript.
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Huff, D.S., Huff, D.S. (2011). Gastrointestinal Tract. In: Ernst, L., Ruchelli, E., Huff, D. (eds) Color Atlas of Fetal and Neonatal Histology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0019-6_3
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DOI: https://doi.org/10.1007/978-1-4614-0019-6_3
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