Abstract
Various diseases have been classified as being autoimmune because responses to self-antigens appear to be involved in their pathogenesis. Numerous theories have been put forward to explain the phenomenon of autoimmunity, but with our current understanding, the two that are most attractive are based on the formation of new and cross-reactive antigens or a loss of normal immune regulation. According to the theory of cross-reactive antigens, an exogenous agent may modify a normal body constituent and increase its antigenicity, or alternatively, antigenic determinants of the agent itself may crossreact with normal host antigens. The concept of a loss of normal immune regulation leading to the development of autoimmunity has become more attractive with increased understanding of the intricacies of immune function. For example, a loss of normal suppressor T cell function could lead to overactivity of other T cells or of the humoral immune system, with resultant abnormal cell- or antibody-mediated immune responses.
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© 1983 Plenum Publishing Corporation
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Morison, W.L. (1983). Autoimmune Disease. In: Parrish, J.A., Kripke, M.L., Morison, W.L. (eds) Photoimmunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3670-9_13
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DOI: https://doi.org/10.1007/978-1-4613-3670-9_13
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