Abstract
Controversy arises in medicine with regard to therapy whenever multiple effective treatments have not been rigorously compared in a controlled fashion. For this reason, various investigators advocate surgery [1, 2], radiation [3, 4], or medical therapy [5, 6] (at least for prolactinomas), as the initial treatment of choice of functioning pituitary tumors. Controlled, prospective clinical trials comparing the relative efficacy and safety of these treatments do not currently exist to guide the choice of therapy for pituitary tumors. Consequently, therapeutic decisions remain subjective and frequently reflect the background training of the physician.
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Santen, R.J., Manni, A. (1984). Controversies in the treatment of endocrine tumors: medical and surgical management of prolactinomas, acromegaly and thyroid cancer. In: Santen, R.J., Manni, A. (eds) Diagnosis and Management of Endocrine-related Tumors. Cancer Treatment and Research, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2849-0_16
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