Abstract
Ras oncogenes were first recognized as the transforming genes of two rat-derived viruses, the Harvey (Ha) and Kirsten (Ki) strains of murine sarcoma virus (MuSV) (1). Molecular cloning studies have identified Ha-ras, Ki-ras, and subsequently, N-ras, as members of a gene family present in a wide range of species including humans (2). At least two mechanisms have been identified by which ras activation can mediate transformation of NIH 3T3 cells: (a) a point mutation in the ras gene resulting in an alteration of a single amino acid in the 21,000 dalton (p21) ras gene product (3), or (b) increased expression of the normal cellular p21 ras gene product (1,4,5).
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© 1985 Martinus Nijhoff Publishing, Boston
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Thor, A. et al. (1985). Monoclonal Antibodies Generated to a Synthetic Peptide Define Ras Gene Expression at the Single Cell Level in Human Colon and Mammary Carcinomas. In: Furmanski, P., Hager, J.C., Rich, M.A. (eds) RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the Frontiers of Understanding. Developments in Oncology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2583-3_13
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DOI: https://doi.org/10.1007/978-1-4613-2583-3_13
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