Abstract
Mouse small intestinal intraepithelial lymphocytes (IEL) are predominantly Lyt 2+ (suppressor/cytotoxic phenotype) T cells. IEL T lymphocytes display immunocompetence in vitro insofar as they respond to Concanavalin A (Con A) and alloantigens (1). There is also some evidence from histologic studies that IEL respond to local stimuli in vivo, because their numbers can be markedly increased (parasite infection; food allergy) or decreased (germ free animals) and many of them have the characteristics of immunoblasts (2). However it is not known whether T cells in the intestinal epithelium have the potential to function in the regulation of gut immune responses as suppressor cells, reflecting their predominantly Lyt 2+ phenotype, or whether they act in the afferent limb of cell mediated immunity by secreting lymphokines.
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© 1985 Plenum Press, New York
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Dillon, S.B., MacDonald, T.T. (1985). Lymphokine Production by T Lymphocytes Isolated from Murine Small Intestinal Epithelium. In: Klaus, G.G.B. (eds) Microenvironments in the Lymphoid System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2463-8_86
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DOI: https://doi.org/10.1007/978-1-4613-2463-8_86
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