Abstract
The pancreatic tissue from 131 human cases with fatal herpes infections were viropathoiogically examined for islet lesions. Diagnoses of all cases were confirmed by virus isolation, serological tests and immunohistochemistry. Focal or massive necrosis, including destruction of beta cells, intranuclear inclusion bodies and inflammatory changes in islets were found in 45 cases, in accordance with the existence of viral antigens. All pancreatic lesions were observed as the expression of a generalized herpesvirus infection and not as solitary damage appearing only in the pancreas. The findings suggest the participation of these viruses in damage to beta cells resulting in diabetes.
If the animal is first treated with a subdiabetogenic dose of beta cell toxin or reovirus, and then injected with murine cytomegalovirus that normally produces little or no diabetes, the cumulative insults induce diabetes. The degu, a rat-like hystricomorph, showed spontaneous diabetes mellitus with characteristic cytomegalovirus inclusion bodies in islet cells.
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© 1987 Martinus Nijhoff Publishing, Boston
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Kurata, T., Sata, T., Iwasaki, T., Onodera, T., Toniolo, A. (1987). Herpes Virus Infections in Human Pancreas Islets and Animal Models. In: Becker, Y. (eds) Virus Infections and Diabetes Mellitus. Developments in Medical Virology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2085-2_8
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DOI: https://doi.org/10.1007/978-1-4613-2085-2_8
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