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Natural Killer Cell Activity in Hashimoto, Graves’ Disease and Euthyroid Exophthalmos

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Thyroid Autoimmunity

Abstract

Natural killer (NK) cells are functionally identified by their ability to lyse a variety of target cells; morphologically they are identified as large granular lymphocytes (LGL). NK cells are augmented by interferon (IF), interleukin 2 (11-2) and inhibited by various agents including certain prostaglandins (PG), e.g. PGE1, PGE2, PGA1 and PGA2. NK cells are thought to play an important role in immune surveillance against cancer and certain infections. Evidence for a role of NK cells in autoimmune disorders is forthcoming. Significantly reduced NK cell activity has been described in patients with systemic lupus erythematosus, Sjögren’s syndrome and multiple sclerosis. In the present study we have characterized the quality and quantity of NK cells in patients with Hashimoto, Graves’ disease and euthyroid exophthalmos

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References

  1. Pedersen B.K., Allergy, 40, 547, 1985.

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Authors and Affiliations

  1. Department of Medicine E,Frederiksberg Hospital, Department of Medicine F, Herlev County Hospital Department of Ophthalmology, Gentofte County Hospital, Laboratory of Medical Immunology TTA, Rigshospitalet University Hospital, Copenhagen, Denmark

    Bente K. Pedersen, Ulla Feldt-Rasmussen, Hans Perrild, Jens Mølholm Hansen & Tom Christensen

Authors
  1. Bente K. Pedersen
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  2. Ulla Feldt-Rasmussen
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  3. Hans Perrild
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  4. Jens Mølholm Hansen
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  5. Tom Christensen
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Editor information

Editors and Affiliations

  1. University of Pisa, Pisa, Italy

    A. Pinchera  & G. F. Fenzi  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    S. H. Ingbar

  3. University of Miami, Miami, Florida, USA

    J. M. McKenzie

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© 1987 Plenum Press, New York

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Pedersen, B.K., Feldt-Rasmussen, U., Perrild, H., Hansen, J.M., Christensen, T. (1987). Natural Killer Cell Activity in Hashimoto, Graves’ Disease and Euthyroid Exophthalmos. In: Pinchera, A., Ingbar, S.H., McKenzie, J.M., Fenzi, G.F. (eds) Thyroid Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0945-1_50

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  • DOI: https://doi.org/10.1007/978-1-4613-0945-1_50

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8258-7

  • Online ISBN: 978-1-4613-0945-1

  • eBook Packages: Springer Book Archive

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