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Tubular and Metabolic Dysfunction Following Kidney Transplantation

  • Chapter
Therapy of Renal Diseases and Related Disorders

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Abstract

The transplanted kidney is exposed to a wide range of injuries. These may afflict the kidney before, during, and after the surgical procedure. The trauma, shock, or morbidity that caused the death of the donor may affect the kidney even before the operation. In addition, the handling of the kidney, the extracorporeal perfusion, and the surgery itself may cause damage to the kidney during the operative and perioperative phase. After transplantation the kidney is also subjected to rejection and other deleterious conditions (summarized in Table 1). The resulting kidney damage is frequently associated with a generalized decrease in renal function characterized by oliguria or anuria of variable duration. Occasionally, however, despite this hostile environment, the glomerular filtration rate is relatively spared and the injury is predominantly tubulointerstitial (see Table 2). These tubular syndromes may cause profound changes in the acid-base balance and disturbances in electrolyte and mineral homeostasis, which may aggravate preexisting bone disease and lead to nephrocalcinosis or nephrolithiasis.

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Authors
  1. J. Winaver
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  2. J. Green
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  3. O. S. Better
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Editors and Affiliations

  1. Baylor College of Medicine, The Methodist Hospital, Houston, Texas, USA

    Wadi N. Suki

  2. Division of Nephrology, University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

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© 1991 Kluwer Academic Publishers

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Winaver, J., Green, J., Better, O.S. (1991). Tubular and Metabolic Dysfunction Following Kidney Transplantation. In: Suki, W.N., Massry, S.G. (eds) Therapy of Renal Diseases and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0689-4_58

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  • DOI: https://doi.org/10.1007/978-1-4613-0689-4_58

  • Publisher Name: Springer, Boston, MA

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