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Assessing LUTS/BPO: What Is the Evidence?

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Male LUTS/BPH Made Easy

Abstract

Lower urinary tract symptoms (LUTS) can be caused by multiple conditions that include benign prostatic obstruction (BPO) as the most important and frequent cause in male patients. During the past decade, the pathophysiology of LUTS/BPO has been completely revisited and many changes in the diagnosis and medical and surgical management of LUTS have evolved and are available in clinical practice. Several national and international urological associations have developed clinical guidelines and algorithms to help diagnosing and managing patients with LUTS/BPO. Patient assessment aims at establishing the pathophysiology of LUTS in the individual subject and includes recommended tests (medical history, quantification of symptoms and bother, physical examination, urinalysis, biochemical tests, frequency volume chart) to be performed in all patients with LUTS/BPO and optional tests (uroflowmetry, post-void residual volume (PVR), urinary tract imaging, pressure–flow studies, and endoscopy of the lower urinary tract) to be considered for the specialized management. The implementation and validation of the available algorithms and guidelines could improve patients’ management and patients/physician communication and finally reduce the number of unneeded examinations in patients with LUTS/BPO reducing the social costs of the disease. The aim of this chapter is to summarize the current evidence on the diagnostic work-up for the management of patients with LUTS/BPO and to highlight differences between different international guidelines or algorithms.

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References

  1. Abrams P, D’ANcona C, Griffiths D, et al. Lower urinary tract symptom: etiology, patient assessment and predicting outcome from therapy. In: McConnell JD, Abrams P, Denis L, Khoury S, Roehrborn CG, eds. 6th International Consultation on New Developments in Prostate Cancer and Prostate Diseases, 2005. Paris, France: Health Publications; 2006:71–141.

    Google Scholar 

  2. Abrams P, Chapple C, Khoury S, et al. Evaluation and treatment of lower urinary tract symptoms in older men. J Urol. 2009;181:1779.

    Article  PubMed  CAS  Google Scholar 

  3. Barry MJ, Fowler Jr FJ, O’Leary MP, Bruskewitz RC, Holtgrewe HL, Mebust WK, Cocket AT. The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J Urol. 1992;148(5):1549–57.

    PubMed  CAS  Google Scholar 

  4. Chapple CR, Roehrborn CG. A shifted paradigm for the further understanding, evaluation and treatment of lower urinary tract symptoms in men: focus on the bladder. Eur Urol. 2006;49(4):651–8.

    Article  PubMed  Google Scholar 

  5. Chodak GW, Kotler P, Shoenberg H. Routine screening for prostate cancer using the digital rectal examination. Prog Clin Biol Res. 1988;269:87.

    PubMed  CAS  Google Scholar 

  6. Coyne K, Lai JS, Zyczynski T, et al. Validation of an overactive bladder awareness tool for use in primary care settings. Adv Ther. 2005;22(4):381–4.

    Article  PubMed  Google Scholar 

  7. Coyne K, Matza LS, Thomson C, et al. The responsiveness of the OAB-q among OAB patients subgroup. Neurourol Urodyn. 2007;26(2):196–203.

    Article  PubMed  Google Scholar 

  8. De Nunzio C, Aroson W, Freedland SJ, Giovannucci E, Kellog Parsons J. The correlation between metabolic syndrome and prostatic diseases. Eur Urol. 2012;61:560–70.

    Article  PubMed  Google Scholar 

  9. Griffiths D, Hofner K, van Mastrigt R, et al. Standardization of terminology of lower urinary tract function: pressure flow studies of voiding urethral resistance and urethral obstruction. Neurourol Urodyn. 1997;16:1–18.

    Article  PubMed  CAS  Google Scholar 

  10. Juliao AA, Plata M, Kazzazi A, Bostanci Y, Djavan B. American Urological Association and European Association of Urology guidelines in the management of benign prostatic hypertrophy: revisited. Curr Opin Urol. 2012;22:34–9.

    Article  PubMed  Google Scholar 

  11. Keqin Z, Zhishun X, Jing Z, et al. Clinical significance of intravesical prostatic protrusion in patients with benign prostatic enlargement. Urology. 2007;70(6):1096.

    Article  PubMed  Google Scholar 

  12. Kirby MG, Wagg A, Cardozo L, et al. Overactive bladder: is there a link to the metabolic syndrome in men? Neurourol Urodyn. 2010;29(8):1360–4.

    Article  PubMed  Google Scholar 

  13. Kupelian V, McVary KT, Kaplan SA, et al. Association of lower urinary tract symptoms and the metabolic syndrome: results from the Boston Area Community Health Survey. J Urol. 2009;182(2):616–24.

    Article  PubMed  Google Scholar 

  14. Manieri C, Carter S, Romano G, Trucchi A, Valenti M, Tubaro A. The diagnosis of bladder outlet obstruction in men by ultrasound measurement of bladder wall thickness. J Urol. 1998;159(3):761–5.

    Article  PubMed  CAS  Google Scholar 

  15. Mc Connel J, Roehrborn C, Bautista OM, et al. The long term effects of doxazosin, finasteride and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med. 2003;349:2387–98.

    Article  Google Scholar 

  16. McConnel JD. Why pressure-flow studies should be optional and not mandatory for evaluating men with benign prostatic hyperplasia. Urology. 1994;44:156.

    Article  Google Scholar 

  17. McConnell JD, Abrams P, Khoury S, et al. Evaluation and treatment of lower urinary tract symptoms (LUTS) in older men. In: McConnell JD, Abrams P, Denis L, Khoury S, Roehrborn CG, eds. 6th International Consultation on New Developments in Prostate Cancer and Prostate Diseases, 2005. Paris, France: Health Publications; 2006:387–401.

    Google Scholar 

  18. McVary KT, Roehrborn CG, Avins AL, et al. Update on AUA guideline on the management of benign prostatic hyperplasia. J Urol. 2011;185:1793–803.

    Article  PubMed  Google Scholar 

  19. National Institute for Health and Clinical Excellence. CG 97 lower urinary tract symptoms: the management of lower urinary tract symptoms in men. London: NICE; 2010. Available from: www.nice.org.uk/guidance/CG97.

  20. Oelke M, Bachmann A, Descazeaud A, et al. Guidelines on management of male lower urinary tract symptoms (LUTS) including benign prostatic obstruction. 2012. Available at: http://www.uroweb.org/fileadmin/user_upload/Guidelines/TreatmentofNonneurogenicmaleLUTS.pdf.

  21. Oelke M, Hofner K, Grunewald BV, Jonas U. Increase in detrusor wall thickness indicates bladder outlet obstruction (BOO) in men. World J Urol. 2002;19:443–52.

    PubMed  Google Scholar 

  22. Oelke M, Kirschner-Hermanns R, Thiruchelvam N, Heesakkers J. Can we identify men who will have complications from benign prostatic obstruction (BPO)? ICI-RS 2011. Neurourol Urodyn. 2012;31:322–6.

    Article  PubMed  Google Scholar 

  23. Resnick M, Ackermann R, Bosch J, et al. Initial evaluation of LUTS. In: Chatelain C, Denis L, Foo KT, et al., editors. Benign prostatic hyperplasia. Paris/Plymouth: Health Publication Ltd.; 2001. p. 169–202.

    Google Scholar 

  24. Roehrborn CG, Malice M, Cook TJ, Girman CJ. Clinical predictors of spontaneous acute urinary retention in men with LUTS and clinical BPH: a comprehensive analysis of the pooled placebo groups of several large clinical trials. Urology. 2001;58:210.

    Article  PubMed  CAS  Google Scholar 

  25. Roehrborn CG, Sech S, Montoya J, Rhodes T, Girman CJ. Interexaminer reliability and validity of three dimensional model to asses prostate volume by digital rectal examination. Urology. 2001;57:1087.

    Article  PubMed  CAS  Google Scholar 

  26. Roherborn CG. Currently available treatment guidelines for men with lower urinary tract symptoms. BJU Int. 2008;102 Suppl 2:18–23.

    Article  Google Scholar 

  27. Staskin D, Kelleher C, Avery K, et al. Initial assessment of urinary and faecal incontinence in adult male and female patients. In: Abrams P, Cardoso L, Khoury S, Wein A, editors. Incontinence. Paris: Health Publication; 2009. p. 331–412.

    Google Scholar 

  28. Tubaro A, Carter S, Hind A, Vicentini C, Miano L. A prospective study of the safety and efficacy of suprapubic transvesical prostatectomy in patients with benign prostatic hyperplasia. J Urol. 2001;166(1):172–6.

    Article  PubMed  CAS  Google Scholar 

  29. Tubaro A, De Nunzio C. Benign prostatic hyperplasia. In: Chapple CCR, Steers WD, editors. Practical urology: essential principles and practice. London: Springer; 2011. p. 361–70.

    Chapter  Google Scholar 

  30. Tubaro A, De Nunzio C, Trucchi A. Lower urinary tract symptoms suggestive of benign prostatic hyperplasia: what is the evidence for rational diagnosis? In: Muir G, Dawson C, editors. Evidence in urology, vol. 11. Bramhills; 2005. p. 89–96.

    Google Scholar 

  31. Tubaro A, Mariani S, De Nunzio C, Miano R. Bladder weight and detrusor thickness as parameters of progression of benign prostatic hyperplasia. Curr Opin Urol. 2010;20:37–42.

    Article  PubMed  Google Scholar 

  32. Tubaro A, Miano L. Managing the consequence of obstruction. Eur Urol. 2002;1(Suppl):21–7.

    Google Scholar 

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Correspondence to Cosimo De Nunzio .

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De Nunzio, C., Autorino, R. (2014). Assessing LUTS/BPO: What Is the Evidence?. In: Chapple, C., Tubaro, A. (eds) Male LUTS/BPH Made Easy. Springer, London. https://doi.org/10.1007/978-1-4471-4688-9_3

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  • DOI: https://doi.org/10.1007/978-1-4471-4688-9_3

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