Summary
Factors leading to development of respiratory muscle fatigue include:
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high inspiratory loads;
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weak inspiratory muscles: neural disease, partial paralysis, disuse atrophy; malnutrition; high CO2, low O2, hypophosphatemia, chronic fatigue;
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low blood perfusion to the respiratory muscles;
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pattern of breathing consisting of long TI/TT, high inspiratory flow (increased inspiratory resistance, exercise, respectively)
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high tidal volume;
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defective coupling between rib cage and diaphragm.
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© 1988 Springer-Verlag Berlin Heidelberg
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Grassino, A. (1988). Pathways leading to skeletal muscle fatigue. In: Grassino, A., Fracchia, C., Rampulla, C., Zocchi, L. (eds) Respiratory Muscles in Chronic Obstructive Pulmonary Disease. Current Topics in Rehabilitation. Springer, London. https://doi.org/10.1007/978-1-4471-3850-1_8
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