Skip to main content
SpringerLink
Log in

Cement with Antimitotics

  • Chapter
Biomechanics and Biomaterials in Orthopedics

  • 896 Accesses

Abstract

There are two causes of failure in the surgical treatment of metastatic tumors: first, local recurrence of the tumor is not always prevented, even after extra-tumoral surgical exeresis and systemic chemotherapy, and secondly, failure of osteosynthesis after surgery. For these reasons, we thought that it would be helpful to provide local chemotherapy during and immediately after surgery, for instance, by adding an antimitotic to the acrylic cement used to replace the bone loss or to seal reconstruction prostheses. It was thought that the antimitotic would be likely to be released into the surrounding tissues in the same way as many antibiotics. Diffusion into the surrounding tissues is well established for numerous antibiotics [1–6].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Buchholz HW, Engelbrecht H. Uber die Depotwirkung einiger Antibiotica bei Vermischung mit dem Kunstharz Palacos Chirurg 1970;41:511–5.

    CAS  Google Scholar 

  2. Carlsson AS, Josefsson G, Lindberg L. Revision with gentamicin-impregnated cement for deep infections in total hip arthroplasties. J Bone Joint Surg [Am] 1978; 60-A:1059–64.

    Google Scholar 

  3. Elson RA, McGechie DB. Antibiotics and acrylic bone cement. J Bone Joint Surg [Br] 1976;58-B:134.

    Google Scholar 

  4. Elson RA, Jephcott AE, McGechie DB, Verettes D. Antibiotic-loaded acrylic cement. J Bone Joint Surg [Br] 1977;59-B:200–5.

    CAS  Google Scholar 

  5. Fischer L-P, Gonon G-P, Carret J-P, Vulliez Y, de Mourgues G. Association methacrylate de methyle (Ciment acrylique) et antibiotique: etude bactériologique et mécanique. Rev Chir Orthop 1977;63:361–72 (Eng. abstr.).

    PubMed  CAS  Google Scholar 

  6. Marks KE, Nelson CL, Lautenschlager EP. Antibiotic-impregnated acrylic bone cement. J Bone Joint Surg [Am] 1976;58-A:358–64.

    Google Scholar 

  7. Hernigou P, Thiery JP, Benoit J et al. Release of antimitotic drugs from acrylic cement and plaster. Eur Surg Res 1987;19(Suppl 1):25.

    Google Scholar 

  8. Hernigou P, Thiery JP, Benoist M et al. Etude expérimentale sur l’osteosarcome d’une chimiothérapie locale diffusant a partir de ciment acrylique chirurgical et de platre. Rev Chir Orthop 1987;73:517–25.

    PubMed  CAS  Google Scholar 

  9. Hernigou P, Thiery JP, Benoit J et al. Methotrexate diffusion from acrylic cement. Bone Joint Surg 1989;71-B:804–11.

    Google Scholar 

  10. Hernigou P, Brun P, Thiery JP et al. Antimitotic loaded acrylic cement. In: Langlais F, editor. Berlin: Springer Verlag, 1991.

    Google Scholar 

  11. Hernigou Ph, Brun B, Autier A et al. Osteosarcoma in Adolescent and Young Adults. Boston: Kluwer Academic, 1993.

    Google Scholar 

  12. Hernigou Ph, Brun B, Astier A et al. Diffusion of methotrexate from acrylic surgical cement. Cancer Treat Res 1993;62:231–5.

    Article  PubMed  CAS  Google Scholar 

  13. Harrington KD, Sim FH, Enis JE et al. Methylmethacry-late as an adjunct in internal fixation of pathological fractures: experience with 375 cases. J Bone Joint Surg (Am) 1976;58-A:1047–55.

    Google Scholar 

  14. Strube HD, Komitowski D. Experimental studies of the treatment of malignant tumors with bone cement. In: Enneking WF, editor. Limb Salvage in Musculoskeletal Oncology. London: Churchill Livingstone, 1987; 459–69.

    Google Scholar 

  15. Brodey RS, Abt DA. Results of surgical treatment in 65 dogs with osteosarcoma. J Am Vet Med Assoc 1976; 168:1032–5.

    PubMed  CAS  Google Scholar 

  16. Ling GV, Morgan JP, Pool RR. Primary bone tumors in the dog: a combinated clinical, radiographic and histologic approach to early diagnosis. J Am Vet Med Assoc 1974;165:55–67.

    PubMed  CAS  Google Scholar 

  17. Misdorp W, Van der Heul RO. Tumours of bones and joints. Bu U WHO 1976;53:265–82.

    CAS  Google Scholar 

  18. Owen LN. Cancer chemotherapy. Vet Ann 1979; 19: 204–11.

    Google Scholar 

  19. Parodi AL. L’osteosarcome (sarcome osteogenigne) chez le chien. Chirurgie 1970;96:75–80.

    PubMed  CAS  Google Scholar 

  20. Pool RR. Bone and cartilage. In: Moulton JE, editor. Tumors in Domestic Animals. 2nd ed. Berkeley: CA, University of California Press, 1978;89–149.

    Google Scholar 

  21. Klein B, Pals S, Masse R et al. Studies of bone and soft-tissue tumours induced in rats with radioactive cerium chloride. Int J Cancer 1977;10(1):12–19.

    Google Scholar 

  22. Thiery JP, Perdereau B, Gongora R, Gongora G, Mazabraud A. Un modele experimental d’osteosarcome chez le rat: 11. L’osteosarcome greffable du rat. Sem Hop Paris 1982;58:1686–9.

    Google Scholar 

  23. Baum ES, Gaynon P, Greenberg L, Krivit W, Hammond D. Phase II study of cis-dichlorodiammineplatinum(II) in childhood osteosarcoma: Children’s cancer study group report. Cancer treatment Reports 1979;63(9–10): 1621–7.

    PubMed  CAS  Google Scholar 

  24. Hiroyuki Tsuchiya, Katsuro Tomita, Hidetoshi Yasutake, Yasutaka Takagi, Shinichi Katsuo et al. Intra-arterial cis-platin and caffeine with/without doxorubicin for musculoskeletal high-grade spindle cell sarcoma. Oncol Rep 1994;1:27–36.

    PubMed  CAS  Google Scholar 

  25. Jaffe N, Keifer R, Robertson R, Cangir A, Wang A. Renal toxicity with cumulative doses of Cis-diamminedichloroplatinum-II in pediatric patients with osteosarcoma. Effect on creatinine clearance and methotrexate excretion. Cancer 1987;59:1577–81.

    Article  PubMed  CAS  Google Scholar 

  26. Litterst CL, LeRoy AF, Guarino AM. Disposition and distribution of platinum following parenteral administration of cis-Dichlorodiammineplatinum(II) to animals. Cancer Treat Rep 1979;63(9–10):1485–92.

    PubMed  CAS  Google Scholar 

  27. Straw RC, Withrow SJ, Douple EB, Brekke JH, Cooper MF et al. Effects of Cis-Diamminedichloroplatinum II released from D,L-Polylactic acid implanted adjacent to cortical allografts in dogs. J Orthop Research 1994;12: 871–7.

    Article  CAS  Google Scholar 

  28. Withrow SJ, Thrall DE, Straw RC, Powers BE, Wrigley RH et al. Intra-arterial cisplatin with or without radiation in limb-sparing for canine osteosarcoma. Cancer 1993;71: 2484–90.

    Article  PubMed  CAS  Google Scholar 

  29. Janmin L. Experimental observations on acrylic bone cement containing antitumor drugs. Natl Med J China 1989;69:143.

    Google Scholar 

  30. Marshall GJ, Kirchen ME, Lee JH, Menendez LA. The effect of methotrexate eluted from bone cement on giant cell tumour lines in vitro. Trans Orthop Res Soc 1990;15:537.

    Google Scholar 

  31. Wang HM, Galasko CS, Crank S, Oliver G, Ward CA. Methotrexate-loaded acrylic cement in the management of skeletal metastases. Clin Orthop 1995;312:173–86.

    PubMed  Google Scholar 

  32. Wu Yang Guan, Wang Tai Yi, Ma Yun Zhi, Sun Shu Zhen. Experimental research on the use of an antineoplastic drug with a bone implant. Int Orthop 1990;14:387–91.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. P. Hernigou
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Service de Chirurgie Orthopédique et de Traumatologie, Centre Hospitalo-Universitaire Nord, Marseille Cedex 20, France

    Dominique G. Poitout MD (Professeur à l’Université de la Mediterranée, Chef de Service) (Professeur à l’Université de la Mediterranée, Chef de Service)

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag London

About this chapter

Cite this chapter

Hernigou, P. (2004). Cement with Antimitotics. In: Poitout, D.G. (eds) Biomechanics and Biomaterials in Orthopedics. Springer, London. https://doi.org/10.1007/978-1-4471-3774-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-3774-0_10

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3776-4

  • Online ISBN: 978-1-4471-3774-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation