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Wound Tissue Oximetry: A Cornerstone in Wound Care

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Measurements in Wound Healing

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Abstract

Non-healing wounds are often represented by inadequate supply of oxygen to the injured tissue. Wound tissue oxygen status needs to be understood and managed in order to secure a favorable outcome. Chronic hypoxia impairs wound healing through a number of mechanisms such as hypoxamir induction resulting in delayed wound closure, impaired collagen synthesis and failed angiogenesis. Inadequate supply of oxygen alone will stifle the healing process and therefore, wound tissue oximetry is a key parameter that must be kept in sight while managing a problem wound. TCOM is the current standard in clinical wound care but is slowly being replaced by optical and EPR-based technology platforms to develop clinical tissue oximetry tools. This chapter explains the significance of hypoxia in wound healing and the current techniques to measure tissue oxygenation status.

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Acknowledgements

This work was supported by NIH grants GM069589 and GM077185 and HL073087 to CK Sen.

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Authors and Affiliations

  1. Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA

    Jaideep Banerjee & Chandan K. Sen Ph.D.

  2. Department of Surgery, 512, Davis Heart and Lung Research Institute, Ohio State University Medical Center, 473 W 12th Ave, Columbus, OH, 43210, USA

    Chandan K. Sen Ph.D.

Authors
  1. Jaideep Banerjee
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  2. Chandan K. Sen Ph.D.
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Correspondence to Chandan K. Sen Ph.D. .

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Editors and Affiliations

  1. School of Medicine, University of Southampton, Tremona Road, Southampton, SO16 6YD, United Kingdom

    Raj Mani

  2. Centro SERRA, Università di Pisa, Lungarno Pacinotti 43, Pisa, 56100, Italy

    Marco Romanelli

  3. Banaras Hindu University, Varanasi, New F. Jodhpur Colony 6, Varanasi, 221 005, India

    Vijay Shukla

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© 2012 Springer-Verlag London

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Banerjee, J., Sen, C.K. (2012). Wound Tissue Oximetry: A Cornerstone in Wound Care. In: Mani, R., Romanelli, M., Shukla, V. (eds) Measurements in Wound Healing. Springer, London. https://doi.org/10.1007/978-1-4471-2987-5_12

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  • DOI: https://doi.org/10.1007/978-1-4471-2987-5_12

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