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Diffuse Large B-Cell Non-Hodgkin’s Lymphoma (DLBCL- NHL)

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Management of Hematological Cancer in Older People

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Abstract

Diffuse large B-Cell Lymphoma (DLBCL) is the most common subtype of maligant lymphoma (ML). The incidence rate is about 10–15 of 100,000 people in the US and in Europe per year. Men are more frequently affected than women [1]. The incidence of DLBCL in people over the age of 65 years is rapidly rising. In the elderly (75 years or older), rates of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma increased 1.4 %. According to the SEER cancer statistics review 2000–2011, 9 per 100,000 of those younger than 65 years develop the disease, compared to 90 per 100,000 in those aged older than 65 years. The 5-years relative survival rates decreases from 78 % in those younger than 65 years to 62 % in those older than 65 years. The occurrence of all Non-Hodkgin’s Lymphomas (NHL) has been rising from 10 to over 20 newly diagnosed patients per 100,000 from 1975 to 2010. For patients over 75 years of age, incidence rates have doubled (50–100 per 100,000) since 1975. Thus DLBCL is predominantly a disease of older individuals, with a median age of diagnosis at approximately 70 years of age. As demographic changes result in an increasing number of older people the occurrence of NHL in this older patient population will pose an increasing problem [2].

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  1. Department of Internal Medicine II, Department of Hematology and Medical Oncology, Jena University Hospital, Erlanger Allee 101, Jena, 07747, Germany

    Nils Winkelmann MD

  2. Department of Palliative Care, University Hospital Jena, Erlanger Allee 101, Jena, 07747, Thüringen, Germany

    Ulrich Wedding MD

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  1. Department of Palliative Care, University Hospital Jena, Jena, Thüringen, Germany

    Ulrich Wedding

  2. St Helens Teaching Hospital, University of Liverpool, St Helens, United Kingdom

    Riccardo A. Audisio

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Winkelmann, N., Wedding, U. (2015). Diffuse Large B-Cell Non-Hodgkin’s Lymphoma (DLBCL- NHL). In: Wedding, U., Audisio, R. (eds) Management of Hematological Cancer in Older People. Springer, London. https://doi.org/10.1007/978-1-4471-2837-3_11

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