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Mechanisms of Calcium Influx Following Stroke

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Metal Ion in Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

Stroke is followed by a dramatic increase in intracellular calcium. This excessive increase in calcium levels is critical in the initiation of neuronal cell death. N-Methyl-d-aspartate (NMDA) receptor and L-type voltage-dependent calcium channel antagonists were unsuccessful at providing neuroprotection following ischemia in clinical trials. Therefore, recent research has focused on identifying novel mechanisms of calcium influx. This chapter reviews the evidence which links various receptors, channels, and transporters to calcium influx following stroke. Particular attention is paid to the therapeutic potential of targeting these various pathways.

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Authors and Affiliations

  1. Department of Anatomy & Cell Biology, University of Western Ontario, London, ON, Canada, N6A 5K8

    Jillian C. Belrose, Brian M. W. Lockhart & John F. MacDonald PhD

  2. Robarts Research Institute, Molecular Brain Research Group, University of Western Ontario, 100 Perth Drive, London, ON, Canada, N6A 5K8

    Fabiana A. Caetano, Kai Yang, Michael F. Jackson & John F. MacDonald PhD

  3. Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada, N6A 5K8

    Michael F. Jackson & John F. MacDonald PhD

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Belrose, J.C., Caetano, F.A., Yang, K., Lockhart, B.M.W., Jackson, M.F., MacDonald, J.F. (2012). Mechanisms of Calcium Influx Following Stroke. In: Li, Y., Zhang, J. (eds) Metal Ion in Stroke. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9663-3_2

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