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The Role of Iron in Brain Following Subarachnoid Hemorrhage

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Metal Ion in Stroke

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

Aneurysmal subarachnoid hemorrhage (SAH) is a serious disease ­causing high morbidity and mortality during early and delayed period. The exact mechanisms underlying brain injury are not fully identified. Recently, experimental studies have revealed that increased subarachnoid hemoglobin and its degradation product iron may play an important role in secondary brain injury following SAH. Treatment with an iron chelator has been proven to reduce brain edema, cerebral vasospasm, and neuronal cell death in a rat model of SAH. Therefore, increased iron deposition perivascular as well as in the brain tissue following subarachnoid ­hemoglobin degradation may be a therapeutic target for SAH patients.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Würzburg, Josef-Schneider-Str. 11, Würzburg, 97080, Germany

    Jin-Yul Lee MD

  2. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Richard F. Keep, Ya Hua, Aditya Pandey & Guohua Xi

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  1. Jin-Yul Lee MD
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  2. Richard F. Keep
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  3. Ya Hua
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  4. Aditya Pandey
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  5. Guohua Xi
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Correspondence to Jin-Yul Lee MD .

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Editors and Affiliations

  1. , Department of Biomedical Sciences, Ohio University, 346 Irvine Hall, Athens, 45701, Ohio, USA

    Yang V. Li

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Lee, JY., Keep, R.F., Hua, Y., Pandey, A., Xi, G. (2012). The Role of Iron in Brain Following Subarachnoid Hemorrhage. In: Li, Y., Zhang, J. (eds) Metal Ion in Stroke. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9663-3_13

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