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Early-Acting Hematopoietic Growth Factors: Biology and Clinical Experience

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Hematopoietic Growth Factors in Oncology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 157))

Abstract

Secreted protein growth factors that stimulate the self-renewal, proliferation, and differentiation of the most primitive stem cells are among the most biologically interesting molecules and at least theoretically have diverse applications in the evolving field of regenerative medicine. Among this class of regulators, the early-acting hematopoietic growth factors and their cellular targets are perhaps the best characterized and serve as a paradigm for manipulating other stem cell based tissues. This chapter reviews the preclinical knowledge accumulated over ∼40 years, since the discovery of the first such growth factor, and the clinical applications of those that, upon testing in humans, ultimately gained regulatory approval for the treatment of various hematological diseases.

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  1. Hematology/Oncology Research Therapeutic Area, Amgen Inc., Thousand Oaks, CA, 91320, USA

    Stephen J. Szilvassy

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Correspondence to Stephen J. Szilvassy .

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  1. Department of Medicine, Duke University and the Duke Comprehensi, Durham, 27705, North Carolina, USA

    Gary H. Lyman

  2. Health Sciences Center, Department of Medicine, University of Washington, Seattle, 98195, Washington, USA

    David C. Dale

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Szilvassy, S.J. (2010). Early-Acting Hematopoietic Growth Factors: Biology and Clinical Experience. In: Lyman, G., Dale, D. (eds) Hematopoietic Growth Factors in Oncology. Cancer Treatment and Research, vol 157. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7073-2_2

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