Abstract
Much research on drug abuse has sought to identify unique behavioral characteristics of individuals who abuse drugs to determine if such characteristics might actually contribute to the etiology of drug abuse. This chapter focuses on impulsivity and reviews several lines of research that point to the role of impaired impulse control in the development and maintenance of drug dependence. A fundamental aspect of impulsivity is an inability to inhibit inappropriate actions or behaviors. Impulsivity is examined as a deficit of inhibitory control and behavioral tasks that assess impairments of inhibitory control in the laboratory are described. Studies of the acute disruptive effects of alcohol on drinkers’ inhibitory control are reviewed, and several lines of evidence point to the specific vulnerability of this behavioral function. Evidence is also presented to show how acute impairment of inhibitory control might contribute to abuse potential of alcohol by promoting excessive “binge” drinking. The chapter concludes by discussing how deficient inhibitory control could represent a fundamental behavioral mechanism by which certain emotional and behavioral states precipitate excessive binge drinking, and how such information might benefit relapse prevention treatments for alcohol abusers.
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References
Abroms, B. D., Fillmore, M. T., Marczinski, C. A. (2003). Alcohol-Induced Impairment of Behavioral Control: Effects on the Alteration and Suppression of Prepotent Responses. Journal of Studies on Alcohol, 64(5), 687–695.
Alderson, R. M., Rapport, M. D., Kofler, M. J. (2007). Attention-deficit/hyperactivity disorder and behavioral inhibition: a meta-analytic review of the stop-signal paradigm. Journal of Abnormal Child Psychology, 35, 745–758.
August, G. J., Winters, K. C., Realmuto, G. M., Fahnhorst, T., Botzet, A., Lee, S. (2006). Prospective study of adolescent drug use among community samples of ADHD and non ADHD participants. Journal of the American Academy of Child and Adolescent Psychiatry, 45(7), 824–832.
Barkley, R. A. (1997). Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychological Bulletin, 121, 65–94.
Barkley, R. A. (2006). Attention-deficit hyperactivity disorder, 3rd ed.: A handbook for diagnosis and treatment. New York, NY: Guilford Press.
Barkley R. A., Guevremont D. C., Anastopoulos A. D., DuPaul G. J., Shelton T. L. (1993). Driving-related risks and outcomes of attention deficit hyperactivity disorder in adolescents and young adults: a 3- to 5-year follow-up survey. Pediatrics, 92(2), 212–218.
Baumeister, R. F., Heatherton, T. F., Tice, D. M. (1994). Losing control: How and why people fail at self-regulation. San Diego, CA: Academic Press.
Collins, R. L. (1993). Drinking restraint and risk for alcohol abuse. Experimental and Clinical Psychopharmacology, 1, 44–54.
Collins, R. L., Lapp, W. M., Izzo, C. V. (1994). Affective and behavioral reactions to the violation of limits on alcohol consumption. Journal of Studies on Alcohol, 55(4), 475–486.
Cummings, C., Gordon, J. R., Marlatt, G. A. (1980) Relapse: prevention and prediction. In W. R. Miller (Ed.), The Addictive Behaviors: Treatment of Alcoholism, Drug Abuse, Smoking, and Obesity (pp. 291–321). Elmsford, NY: Pergamon Press.
Cyders, M. A., Smith, G. T. (2008). Emotion-based dispositions to rash action: Positive and negative urgency Psychological Bulletin, 134(6), 807–828.
de Wit, H., Crean, J., Richards, J. B. (2000). Effects of d-amphetamine and ethanol on a measure of behavioral inhibition in humans. Behavioral Neuroscience, 114, 830–837.
Evenden, J. L. (1999). Varieties of impulsivity. Psychopharmacology, 146, 348–361.
Fillmore, M. T. (2007). Acute alcohol induced impairment of cognitive functions: Past and present findings. International Journal on Disability and Human Development, 6, 115–125.
Fillmore, M. T. (2003). Drug abuse as a problem of impaired control: current approaches and findings. Behavioral and Cognitive Neuroscience Reviews, 2, 179–197.
Fillmore, M. T., Blackburn, J. S., Harrison, E. L. R. (2008). Acute disinhibiting effects of alcohol as a factor in risky driving behavior. Drug and Alcohol Dependence, 95(1–2), 97–106.
Fillmore, M. T., Marczinski, C. A., & Bowman, A. M. (2005). Acute tolerance to alcohol effects on inhibitory and activational mechanisms of behavioral control. Journal of Studies on Alcohol, 66, 663–672.
Fillmore, M. T., Rush, C. R., & Hays, L. (2002). Acute effects of oral cocaine on inhibitory control of behavior in humans. Drug and Alcohol Dependence, 67, 157–167.
Fillmore, M. T., Vogel-Sprott, M. (1999). An alcohol model of impaired inhibitory control and its treatment in humans. Experimental and Clinical Psychopharmacology, 7, 49–55.
Fillmore, M. T., Vogel-Sprott, M. (2000). Response inhibition under alcohol: Effects of cognitive and motivational conflict. Journal of Studies on Alcohol, 61(2), 239–246.
Fillmore, M. T., Weafer, J. (2004). Alcohol impairment of behavior in men and women. Target Article. Addiction, 99, 1237–1246.
Flory, K., Milich, R., Lynam, D. R., Leukefeld, C., Clayton, R. (2003). Relation between childhood disruptive behavior disorders and substance use and dependence symptoms in young adulthood: Individuals with symptoms of attention deficit/hyperactivity disorder are uniquely at risk. Psychology of Addictive Behaviors, 17(2), 151–158.
Fowles, D. C. (1987). Application of a behavioral theory of motivation to the concepts of anxiety and impulsivity. Journal of Research on Personality, 21, 417–435.
Goudriaan, A. E., Grekin, E. R., Sher, K. J. (2007). Decision making and binge drinking: A longitudinal study. Alcoholism: Clinical and Experimental Research, 31, 928–938.
Gray, J. A. (1976). The behavioral inhibition system: A possible substrate for anxiety. In: M. P. Feldman and A. Broadhurst (Eds.), Theoretical and Experimental Bases of Behavior Therapies (pp. 3–41). London: Wiley.
Grekin, E. R., Sher, K. J., Wood, P. K. (2006). Personality and Substance Dependence Symptoms: Modeling Substance-Specific Traits. Psychology of Addictive Behaviors, 20(4), 415–424.
Jentsch, J. D., Taylor, J. R. (1999). Impulsivity resulting from frontostriatal dysfunction in drug abuse: implication for the control of behavior by reward-related stimuli. Psychopharmacology, 146, 373–390.
Jonah, B. A. (1997). Sensation seeking and risky driving: A review and synthesis of the literature. Accident Analysis & Prevention, 29(5), 651–665.
Kalant H., LeBlanc, A. E., Gibbons, R. J. (1971). Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacological Reviews, 23, 135–191.
Lijffijt, M., Kenemans, J. L., Verbaten, M. N., van Engeland, H. (2005). A Meta-Analytic Review of Stopping Performance in Attention-Deficit/Hyperactivity Disorder: Deficient Inhibitory Motor Control? Journal of Abnormal Psychology, 114, 216–222.
Logan, G. D., Cowan, W. B. (1984). On the ability to inhibit thought and action: A theory of an act of control. Psychological Review, 91(3), 295–327.
Logan, G. D. (1994). On the ability to inhibit thought and action: A user’s guide to the stop- signal paradigm. In: Dagenbach D, Carr TH (Eds.), Inhibitory Processes in Attention, Memory, and Language (pp. 189–239). San Diego, CA: Academic Press.
Logan, G. D., Schachar, R. J., Tannock, R. (1997). Impulsivity and inhibitory control. Psychological Science, 8(1), 60–64.
Lyvers, M. (2000). “Loss of control” in alcoholism and drug addiction: A neuroscientific interpretation. Experimental and Clinical Psychopharmacology, 8, 225–249.
Malloy, P., Bihrle, A., Duffy, J., Cimino, C. (1993). The orbitomedial frontal syndrome. Archives of Clinical Neuropsychology, 8, 185–201.
Marczinski, C. A., Fillmore, M. T. (2003). Pre-response cues reduce the impairing effects of alcohol on the execution and suppression of responses. Experimental and Clinical Psychopharmacology, 11, 110–117.
Marczinski, C. A., Combs, S. W., Fillmore, M. T. (2007). Increased sensitivity to the disinhibiting effects of alcohol in binge drinkers. Psychology of Addictive Behaviors, 21, 346–354.
Marczinski, C. A., Abroms, B. D., Van Selst, M., Fillmore, M. T. (2005). Alcohol- induced impairment of behavioral control: Differential effects on engaging vs. disengaging responses. Psychopharmacology, 182(3), 452–459.
Marlatt, G. A., George, W. H. (1984). Relapse prevention: Introduction and overview of the model. British Journal of Addiction, 79(3), 261–273.
Maylor, E. A., Rabbitt, P. M., James, G. H., Kerr, S. A. (1992). Effects of alcohol, practice, and task complexity on reaction time distributions. Quarterly Journal of Experimental Psychology: Human Experimental Psychology, 49(A), 119–139.
Miller, J., Schaffer, R., Hackley, S. A. (1991). Effects of preliminary information in a go versus no go task. Acta Psychologica, 76, 241–292.
Miller, W. R., (1996). What is a relapse? Fifty ways to leave the wagon. Addiction, 91(12), S15–S27.
Molina, B. S. G., Smith, B. H., Pelham, W. E. (1999). Interactive effects of attention deficit hyperactivity disorder and conduct disorder on early adolescent substance use. Psychology of Addictive Behaviors, 13, 348–358.
Mulvihill, L. E., Skilling, T. A., Vogel-Sprott, M. (1997). Alcohol and the ability to inhibit behavior in men and women. Journal of Studies on Alcohol, 58, 600–605.
Muraven, M., Collins, R. L., Neinhaus, K. (2002). Self-control and alcohol restraint: An initial application of the Self-Control Strength Model. Psychology of Addictive Behaviors, 16(2), 113–120.
Nigg, J. T. (2006). What causes ADHD? Understanding what goes wrong and why. New York: Guilford Press.
Oosterlaan, J., Logan, G. D., Sergeant, J. A., Response C. D. (1998). Response CD, anxious, and control + inhibition in AD/HD, CD, comorbid AD/HD children: A meta-analysis of studies with the stop task. Journal of Child Psychology and Psychiatry, 39(3), 411–425.
Pihl R. O., Paylan S. S., Gentes-Hawn A., Hoaken P. N. (2003). Alcohol affects executive cognitive functioning differentially on the ascending versus descending limb of the blood alcohol concentration curve. Alcoholism: Clinical and Experimental Research, 27(5), 773–779.
Roehrich, L., Goldman, M. S. (1995). Implicit priming of alcohol expectancy memory processes and subsequent drinking behavior. Experimental and Clinical Psychopharmacology, 3(4), 402–410.
Schweizer, T. A., Jolicoeur, P., Vogel-Sprott, M., Dixon, M. J. (2004). Fast, but error-prone, responses during acute alcohol intoxication: Effects of stimulus-response mapping complexity. Alcoholism: Clinical and Experimental Research, 28(4), 643–649.
Sher, K. J., Trull, T. J. (1994). Personality and disinhibitory psychopathology: alcoholism and antisocial personality disorder. Journal of Abnormal Psychology, 103, 92–102.
Stein, K. D., Goldman, M. S., Del Boca, F. K. (2000). The influence of alcohol expectancy priming and mood manipulation on subsequent alcohol consumption. Journal of Abnormal Psychology, 109(1), 106–115.
Tannock, R. (1998). Attention deficit hyperactivity disorder: Advances in cognitive, neurobiological, and genetic research. Journal of Child Psychology and Psychiatry, 39, 65–99.
Tice, D. M., Bratslavsky, E., Baumeister, R. F. (2001). Emotional distress regulation takes precedence over impulse control: If you feel bad, do it! Journal of Personality and Social Psychology, 80(1), 53–67.
Trull, T. J., Waudby, C. J., Sher, K. J. (2004). Alcohol, Tobacco, and Drug Use Disorders and Personality Disorder Symptoms. Experimental and Clinical Psychopharmacology, 12(1), 65–75.
Weafer, J., Fillmore, M. T. (2008). Individual differences in acute alcohol impairment of inhibitory control predict ad libitum alcohol consumption. Psychopharmacology, 201, 315–324.
Weafer, J., Camarillo, D., Fillmore, M. T., Milich, R., Marczinski, C. A. (2008). Simulated driving performance of adults with ADHD: comparisons with alcohol intoxication. Experimental and Clinical Psychopharmacology, 16, 251–263.
Weafer, J., Fillmore, M. T., Milich, R. (2009). Increased sensitivity to the disinhibiting effects of alcohol in adults with ADHD. Experimental and Clinical Psychopharmacology, 17, 113–121.
Wechsler, H., Lee, J. E., Kuo, M., Lee, H. (2000). College binge drinking in the 1990s: A continuing problem: Results of the Harvard School of Public Health 1999 College Alcohol Study. Journal of American College Health, 48(5), 199–210.
Widiger, T. A., Smith, G. T. (1994). Substance use disorder: Abuse, dependence and dyscontrol. Addiction, 89, 267–282.
Wiers, R. W., Stacy, A. W. (2006). Implicit Cognition and Addiction. Current Directions in Psychological Science, 15(6), 292–296.
Witkiewitz, K., Marlatt, G. A., Walker, D. (2005). Mindfulness-based relapse prevention for alcohol and substance use disorders. Journal of Cognitive Psychotherapy, 19, 211–228.
Acknowledgment
This research was supported by Award Number R01 AA12895, R01 AA018274, and F31 AA018584 from the National Institute on Alcohol Abuse and Alcoholism and by Award Number R21 DA021027 from the National Institute on Drug Abuse.
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Fillmore, M.T., Weafer, J. (2011). Impaired Inhibitory Control as a Mechanism of Drug Abuse. In: Bardo, M., Fishbein, D., Milich, R. (eds) Inhibitory Control and Drug Abuse Prevention. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1268-8_5
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