AAA Proteins

AAA Proteins are ATPases, enzymes cleaving off phosphates from ATP. They are equipped with Walker boxes. AAA domain proteins are molecular chaperones and have important roles in vesicular transport, organelle biogenesis, microtubule rearrangements, etc. Some of this group of enzymes is related to the prokaryotic RuvA proteins. The Mgs1 protein (maintenance of genome stability) of yeast has homologs in all prokaryotes and eukaryotes. Their defects contribute to increased mitotic recombination. ATP, ATPase, RuvABC, chaperone, Walker box, MDl1; Dalal S, Hanson PI 2001 Cell 104:5; Gadal O et al 2001 EMBO J 20:3695; Hishida T et al 2001 Proc Natl Acad Sci USA 98:8283; Sauer RT et al 2004 Cell 119:9; evolution and structure: Erzberger JP, Berger JM 2006 Annu Rev Biophys Biomol Struct 35:93.