Abstract
The transient receptor potential vanilloid 4 (TRPV4), a member of the TRP family that has a 6-transmembrane (TM) segment, was first identified as a hypoosmolality-activated Ca2+ permeable channel. The mechanism of opening by hypoosmolality is distinct from direct coupling of membrane tension with conformational changes, such as that which occurs with Msc or TREK, in which phospholipase A2 is sensitive to hypoosmolality and the resulting arachidonic acid metabolites open this channel. TRPV4 is, however, a “multi-micromachine” that senses more diverse physical stimuli and converts them to the Ca2+ signal in various mammalian tissues. Recent analyses suggest that TRPV4 and other molecules together constitute a physiological response, such as cell volume regulation, epithelial permeability, and vascular dilatation. A mouse lacking the TRPV4 gene appeared normal but had unexpected responses to various stimuli; this will provide a clue to elucidate a novel physiological, pathophysiological, and pharmacological significance in the sensation of physical factors.
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References
Alessandri-Haber N, Yeh JJ, Boyd AE, Parada CA, Chen X, Reichling DB, Levine JD. (2003) Hypotonicity induces TRPV4-mediated nociception in rat. Neuron. 39:497–511.
Alessandri-Haber N, Dina OA, Yeh JJ, Parada CA, Reichling DB, Levine JD. (2004) Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J Neurosci 24:4444–4452.
Alessandri-Haber N, Joseph E, Dina OA, Liedtke W, Levine JD. (2005) TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain 118:70–79.
Alessandri-Haber N, Dina OA, Joseph EK, Reichling D, Levine JD. (2006) A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. J Neurosci 26:3864–3874.
Alvarez DF, King JA, Weber D, Addison E, Liedtke W, Townsley MI.(2006) Transient Receptor Potential Vanilloid 4-Mediated Disruption of the Alveolar Septal Barrier. A Novel Mechanism of Acute Lung Injury. Circ Res (in press).
Andrade YN, Fernandes J, Vazquez E, Fernandez-Fernandez JM, Arniges M, Sanchez TM, Villalon M, Valverde MA. (2005) TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol. 168:869–874.
Arniges M, Fernandez-Fernandez JM, Albrecht N, Schaefer M, Valverde MA (2006). Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem 281:1580–1586.
Arniges M, Vazquez E, Fernandez-Fernandez JM, Valverde MA. (2004) Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J Biol Chem 279:54062–54068.
Basavappa S, Pedersen SF, Jorgensen NK, Ellory JC, and Hoffmann EK. (1998) Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells. J Neurophysiol 79: 1441–1449.
Becker D, Blase C, Bereiter-Hahn J, Jendrach M. (2005) TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci 118:2435–2440.
Benham CD, Gunthorpe MJ, Davis JB. (2003) TRPV channels as temperature sensors Cell Calcium 33:479–487.
Boulant JA. (2000) Role of the preoptic-anterior hypothalamus in thermoregulation and fever. Clin Infect Dis 31: S157–S161, 2000.
Bourque CW, Oliet SH. (1997) Osmoreceptors in the central nervous system. Annu Rev Physiol 59: 601–619.
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 389, 816–824.
Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288: 306–313.
Caterina MJ. (2006) Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am J Physiol Regul Integr Comp Physiol. (in press).
Chakfe Y, Bourque CW. (2000) Excitatory peptides and osmotic pressure modulate mechanosensitive cation channels in concert. Nat Neurosci 3:572–579.
Chung MK, Lee H, Caterina MJ. (2003) Warm temperatures activate TRPV4 in mouse 308 keratinocytes. J Biol Chem. 278:32037–32046.
Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ (2004a) TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem. 279:21569–21575.
Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ. (2004b) 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci. 24: 5177–5182.
Clapham DE, Runnels LW, Strubing C. (2001) The trp ion channel family. Nat Rev Neurosci 2: 387–396.
Cohen DM (2005) TRPV4 and the mammalian kidney. Pflugers Arch. 451:168–175.
Colbert HA, Smith TL, Bargmann CI. (1997) OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci 17:8259–69.
Corey DP. (2006) What is the hair cell transduction channel? J Physiol. (in press).
Cuajungco MP, Grimm C, Oshima K, D’hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S. (2006) PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem 281:18753–18762.
Dhaka A, Viswanath V, Patapoutian A. (2006) Trp ion channels and temperature sensation. Annu Rev Neurosci. 29:135–161.
Delany NS, Hurle M, Facer P, Alnadaf T, Plumpton C, Kinghorn I, See CG, Costigan M, Anand P, Woolf CJ, Crowther D, Sanseau P, Tate SN. (2001) Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics. 19:165–167.
Dietrich A, Chubanov V, Kalwa H, Rost BR, Gudermann T. (2006) Cation channels of the transient receptor potential superfamily: Their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther. 2006 (in press).
Earley S, Heppner TJ, Nelson MT, Brayden JE (2005) TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels.Circ Res. 97: 1270–1279.
Frangos JA, Eskin SG, McIntire LV, Ives CL. (1985) Flow effects on prostacyclin production by cultured human endothelial cells. Science. 227:1477–1479.
Fu Y, Subramanya A, Rozansky D, Cohen DM. (2006) WNK kinases influence TRPV4 channel function and localization. Am J Physiol Renal Physiol. 290:F1305–1314.
Gamba G. (2006) TRPV4: a new target for the hypertension-related kinases WNK1 and WNK4.Am J Physiol Renal Physiol. 290:F1303–4.
Gao X, Wu L, O’Neil RG.J (2003) Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. Biol Chem. 278:27129–27137.
Greene CG, Pamella M. McMillan, SE. Barker, Purnima K, Margaret I. Burmeister LM, Lesperance LM. (2001) DFNA25, a Novel Locus for Dominant Nonsyndromic Hereditary Hearing Impairment, Maps to 12q21–24 Am. J Hum. Genet 68:254–260.
Guatteo E, Chung KK, Bowala TK, Bernardi G, Mercuri NB, Lipski J. (2005) Temperature sensitivity of dopaminergic neurons of the substantia nigra pars compacta: involvement of transient receptor potential channels.J Neurophysiol. 94:3069–80.
Gunthorpe MJ, Benham CD, Randall A, Davis JB. (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci 23: 183–191.
Guler AD, Lee H, Iida T, Shimizu I, Tominaga M, Caterina M.J (2002) Heat-evoked activation of the ion channel, TRPV4. Neurosci. 22:6408–6414.
Hebert SC, Brown EM, Harris HW. (1997) Role of the Ca(2+)-sensing receptor in divalent mineral ion homeostasis. J Exp Biol 200:295–302.
Hellwig N, Albrecht N, Harteneck C, Schultz G, Schaefer M. (2005) Homo- and heteromeric assembly of TRPV channel subunits J Cell Sci. 118:917–928.
Hoenderop JG, Nilius B, Bindels RJ. (2005) Calcium absorption across epithelia. Physiol Rev 85:373–422.
Hori A, Minato K, Kobayashi S. (1999) Warming-activated channels of warmsensitiveneurons in rat hypothalamic slices. Neurosci Lett 275:93–96.
Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee LY, Wood JD, Zhu MX. (2004) 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem 279: 35741–35748.
Jia Y, Wang X, Varty L, Rizzo CA, Yang R, Correll CC, Phelps PT, Egan RW, Hey JA. (2004) Functional TRPV4 channels are expressed in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 287:L272–278.
Jordt SE, Julius D. Molecular basis for species-specific sensitivity to “hot” chili peppers. (2002) Cell 108: 421–430.
Kochukov MY, McNearney TA, Fu Y, Westlund KN. (2006) Thermosensitive TRP Ion Channels Mediate Cytosolic Calcium Response in Human Synoviocytes. Am J Physiol Cell Physiol. 291: C424–432.
Koehler R, Heyken WT, Heinau P, Schubert R, Si H, Kacik M, Busch C, Grgic I, Maier T, Hoyer J. (2006) Evidence for a Functional Role of Endothelial Transient Receptor Potential V4 in Shear Stress-Induced Vasodilatation. Arterioscler Thromb Vasc Biol. 26:1495–1502.
Kotlikoff MI (2005) EDHF redux: EETs, TRPV4, and Ca2+ sparks. Circ Res. 97:1209–1210.
Krause JE, Chenard BL, Cortright DN (2005) Transient receptor potential ion channels as targets for the discovery of pain therapeutics.Curr Opin Investig Drugs 6:48–57.
Kunert-Keil C, Bisping F, Kruger J, Brinkmeier H. (2006) Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains. BMC Genomics. 7:159.
Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP. (2006) TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 250:277–289.
Lee H, Iida T, Mizuno A, Suzuki M, Caterina MJ. (2005) Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci. 25:1304–1310.
Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH. (2005) Properties of WNK1 and implications for other family members. J Biol Chem 280: 26653–26658.
Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S. (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell. 103:525–535.
Liedtke W, Friedman JM. (2003a) Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A. 100:13698–13703.
Liedtke W, Tobin DM, Bargmann CI, Friedman JM. (2003b) Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 100:14531–6.
Liedtke W, Simon SA. (2004) A possible role for TRPV4 receptors in asthma. Am J Physiol Lung Cell Mol Physiol. 287:L269–71.
Liedtke W. (2005a) TRPV4 as osmosensor: a transgenic approach. Pflugers Arch. 451:176–80.
Liedtke W. (2005b) TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. J Physiol. 567:53–8.
Lipski J, Park TI, Li D, Lee SC, Trevarton AJ, Chung KK, Freestone PS, Bai JZ. (2006) Involvement of TRP-like channels in the acute ischemic response of hippocampal CA1 neurons in brain slices. Brain Res. 1077:187–199.
Liu X, Bandyopadhyay BB, Nakamoto T, Singh BB, Liedtke W, Melvin JE, Ambudkar IS. (2006) A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem 281:15485–15495.
Hernández M, Burillo SL, Crespo MS, Nieto ML. (1998) Secretory phospholipase A2 activates the cascade of mitogen-activated protein kinases and cytosolic phospholipase A2 in the human astrocytoma cell line 1321N1. Biol. Chem 273: 606–612.
Iida T, Shimizu I, Nealen MI, Campbell A, Caterina M. (2005) Attenuated fever response in mice lacking TRPV1. Neuroscience let 378: 28–32.
Maroto R, Raso A, Wood TG, Kurosky A, Martinac B, Hamill OP. (2005) TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol. 7:179–185.
Martinez CG, Palao CM, Cases RP, Merino JM, Montiel F A. (2000) Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties. J Biol Chem 275:32552–32558.
Mizuno A, Matsumoto N, Imai M, Suzuki M. (2003) Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol. 285: C96–101.
Montell C. (2001) Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Science’s STKE 10.
Montell C, Birnbaumer L, Flockerzi V. (2002a) The TRP channels, a remarkable functional family. Cell 108: 595–598.
Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham D, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu S, Zhu MX. (2002b) A unified nomenclature for the superfamily of TRP cation channels. Mol Cell 9: 229–231.
Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN, Spencer KS, Andahazy M, Story GM, Patapoutian A. (2005) Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science. 307: 1468–1472.
Morris, CE, Sigurdson, WJ. (1989) Stretch-inactivated ion channels co-exist with stretch-activated ion channels. Science 243: 807–809.
Naeini SR, Witty MF, Seguela P, Bourque CW. (2006) An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci. 9:93–98.
Nilius B, Prenen J, Wissenbach U, Bodding M, Droogmans G. (2001a) Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells. Pflugers Arch 443:227–233.
Nilius B, Vennekens R, Prenen J, Hoenderop JG, Droogmans G, Bindels RJ. (2001b) The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel. J Biol Chem 276: 1020–1025.
Nilius B, Watanabe H, Vriens J. (2003) The TRPV4 channel: structure-function relationship and promiscuous gating behaviour. Pflugers Arch. 446:298–303.
Nilius B, Vriens J, Prenen J, Droogmans G, Voets T. (2004) TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol. 286:C195–205.
O’Neil RG, Heller S (2005) The mechanosensitive nature of TRPV channels. Pflugers Arch. 451:193–203.
Owsianik G, D’hoedt D, Voets T, Nilius B. (2006) Structure-function relationship of the TRP channel superfamily. Rev Physiol Biochem Pharmacol. 156:61–90.
Reiter B, Kraft R, Gunzel D, Zeissig S, Schulzke JD, Fromm M, Harteneck C.(2006) TRPV4-mediated regulation of epithelial permeability. FASEB J. 20:1802–1812.
Schumacher MA, Moff I, Sudanagunta SP, Levine JD. (2000) Molecular Cloning of an N-terminal Splice Variant of the Capsaicin Receptor. J. Biol. Chem 275: 2756 - 2762.
Shen, J., Harada S., N, Kubo N, Liu B, Mizuno A, Suzuki M, Yamashita T. (2006) Functional expression of transient receptor potential vanilloid 4 in the mouse cochlea. Neuroreport 17:135–139.
Sidhaye VK, Guler AD, Schweitzer KS, D’Alessio F, Caterina MJ, King LS. (2006) Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. Proc Natl Acad Sci U S A. 103:4747–4752.
Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. (2006) Bisandrographolide from Andrographis Paniculata activates TRPV4 channels. J Biol Chem. (in press).
Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol. 2:695–702.
Strotmann R, Schultz G, Plant TD. (2003) Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a carboxy terminal calmodulin binding site. J Biol Chem 278: 26541–26549.
Suzuki M, Sato J, Kutsuwada K, Ooki G, Imai M. (1999) Cloning of a stretch-inhibitable nonselective cation channel. J Biol Chem 274:6330–5335.
Suzuki M, Mizuno A, Kodaira K, Imai M. (2003a) Impaired pressure sensation in mice lacking TRPV4. J Biol Chem 278:22664–22668.
Suzuki M, Watanabe Y, Oyama Y, Mizuno A, Kusano E, Hirao A, Ookawara S. (2003b) Localization of mechanosensitive channel TRPV4 in mouse skin. Neurosci Lett. 353:189–192.
Suzuki M, Hirao A, Mizuno A. (2003c) Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).J Biol Chem 278:51448–51453.
Tabuchi K, Suzuki M, Mizuno A, Hara A. (2005) Hearing impairment in TRPV4 knockout mice. Neurosci Lett. 382:304–308.
Takumida M, Kubo N, Ohtani M, Suzuka Y, Anniko M. (2005) Transient receptor potential channels in the inner ear: presence of transient receptor potential channel subfamily 1 and 4 in the guinea pig inner ear. Acta Otolaryngol. 125:929–934.
Taniguchi J, Tsuruoka S, Mizuno A, Sato J, Fujimura A, Suzuki M. (2006) TRPV4 as a flow sensor in flow-dependent K+ secretion from the cortical collecting duct. Am J Physiol Renal Physiol. (in press).
Teilmann SC, Byskov AG, Pedersen PA, Wheatley DN, Pazour GJ, Christensen ST. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev. 71:444–452.
Tian W, Salanova M, Xu H, Lindsley JN, Oyama TT, Anderson S, Bachmann S, Cohen DM. (2004) Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments.Am J Physiol Renal Physiol. 287: F17–24.
Todaka H, Taniguchi J, Satoh J, Mizuno A, Suzuki M. (2004) Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia. J Biol Chem 279: 35133–35138.
Tsushima H, Mori M. (2006) Antidipsogenic effects of a TRPV4 agonist, 4{alpha}-phorbol 12, 13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol. 290:R1736–1741.
Voets T, Prenen J, Vriens J, Watanabe H, Janssens A, Wissenbach U, Bodding M, Droogmans G, Nilius B. (2002) Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem 277:33704–33710.
Voets T, Talavera K, Owsianik G, Nilius B. (2005) Sensing with TRP channels. Nat Chem Biol.1: 85–92.
Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B. (2003) Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A. 101:396–401.
Vriens J, Janssens A, Prenen J, Nilius B, Wondergem R. (2004) TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells. Cell Calcium. 36:19–28.
Vriens J, Owsianik G, Fisslthaler B, Suzuki M, Janssens A, Voets T, Morisseau C, Hammock BD, Fleming I, Busse R, Nilius B. (2005) Modulation of the Ca2+ permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium Circ Res. 28;:908–915.
Watanabe H, Davis JB, Smart D, Jerman JC, Smith GD, Hayes P, Vriens J, Cairns W, Wissenbach U, Prenen J, Flockerzi V, Droogmans G, Benham CD, Nilius B (2002a) Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem 277:13569–13577.
Watanabe H, Vriens J, Suh SH, Benham CD, Droogmans G, Nilius B. (2002b) Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem. 277: 47044–47051.
Watanabe H, Vriens J, Janssens A, Wondergem R, Droogmans G, Nilius B. (2003a) Modulation of TRPV4 gating by intra- and extracellular Ca2+. Cell Calcium. 33:489–495.
Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B. (2003b) Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424: 434–438.
Wechselberger M, Wright CL, Bishop GA, Boulant JA (2006) Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity. Am J Physiol Regul Integr Comp Physiol 291: R518–29.
Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. (2001) Human hypertension caused by mutations in WNK kinases. Science 293: 1107–1112.
Wissenbach U, Bodding M, Freichel M, Flockerzi V. (2000) Trp12, a novel Trp related protein from kidney. FEBS Lett 485: 127–134.
Xu F, Satoh E, Iijima T. (2003) Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.Br J Pharmacol. 140:413–421.
Xu H, Zhao H, Tian W, Yoshida K, Roullet JB, Cohen DM (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stressJ Biol Chem 278:11520–11527.
Xu H, Fu Y, Tian W, Cohen DM. (2006) Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking. Am J Physiol Renal Physiol. 2290: F1103–9.
Yao X, Garland CJ (2005) Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res 97:853–863.
Yang XR, Lin MJ, McIntosh LS, Sham JS. (2006) Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle. Am J Physiol Lung Cell Mol Physiol 290:L1267–1276.
Zhang L, Jones S, Brody K, Costa M, Brookes SJ. (2004) Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse. Am J Physiol Gastrointest Liver Physiol. 286:G983–991.
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Suzuki, M. (2008). Mechanosensitive Channel TRPV4. In: Kamkin, A., Kiseleva, I. (eds) Mechanosensitive Ion Channels. Mechanosensitivity in Cells and Tissues, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6426-5_9
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