Abstract
This unique subtype of adenocarcinoma is primarily characterized by its distinctive architectural growth pattern. In this type of growth pattern, called lepidic pattern, the tumor cells spread along intact pre-existing alveolar walls. Mucinous, non-mucinous, and mixed variants are recognized. In addition to this architectural growth pattern, demonstration of vascular, pleural or stromal invasion is required for a definite diagnosis of bronchioloalveolar carcinoma. Current WHO criteria indicate that in the absence of invasion, this lesion is essentially an in-situ tumor.
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Blackmon, S., Cagle, P.T., Allen, T.C., Mody, D.R., Fraire, A.E. (2010). Bronchioloalveolar Carcinoma. In: Fraire, A., et al. Atlas of Neoplastic Pulmonary Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-89839-1_37
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DOI: https://doi.org/10.1007/978-0-387-89839-1_37
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