Abstract
Some pediatric disorders with biogenetic or neuropsychological causes may require medical treatments (Wilens, 2001). Most of these disorders, however, require multimodal treatments, where medication is used in combination with other psychosocial and behavioral interventions or therapies. A select list of common medications will be reviewed, including those designed to control ADHD, major depressive disorders, bipolar disorders, psychotic disorders, Tourette syndrome, and seizure disorders. The National Institute of Mental Health (NIMH) has funded a number of studies to investigate the safety and efficacy of medications and psychosocial interventions for common childhood and adolescent disorders. These will be briefly reviewed.
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References
Abikoff, M., Hechtman, L., Klein, R., Weiss, K., Fleiss, K., Etcovitch, J., et al. (2004). Symptomatic improvement in children with ADHD treated with long-term methylphenidate and multimodal psychosocial treatment. Journal of the American Academy of Child and Adolescent Psychiatry, 43, 802–811.
Balthazor, M. J., Wagner, R. K., & Pelham, W. E. (1991). The specificity of the effects of stimulant medications on classroom-learning related measures of cognitive processing for attention deficit disorder children. Journal of Abnormal Child Psychology, 19, 35–52.
Barkley, R. A., (2006). Attention-deficit hyperactivity disorder: A handbook for diagnosis and treatment (3rd ed.). New York: Guilford Press.
Barkley, R. A., Anderson, D. L., & Kruesi, M. (2007). A pilot study of the effects of Atomexetine on driving in adults with ADHD. Journal of Attention Disorders, 10, 306–316.
Barkley, R. A., & Cunningham, C. E. (1979). Stimulant drugs and activity level in hyperactive children. American Journal of Orthopsychiatry, 49,491–499.
Barkley, R. A., & Cunningham, C. E. (1980). The parent-child interactions of hyperactive children and their modification by stimulant drugs. In R. Knights & D. Bakker (Eds.), Treatment of hyperactive and learning disabled children (pp. 219–236). Baltimore, MD: University Park Press.
Barkley, R. A., DuPaul, G. J., & McMurray, M. B. (1991). Attention deficit disorder with and without hyperactivity: Clinical response to three doses of methylphenidate. Pediatrics, 87, 519–531.
Barkley, R. A., Fischer, M., Smallish, L., & Fletcher, K. (2006). Young adult outcome of hyperactive children: Adaptive functioning in major life activities. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 192–202.
Barkley, R. A., Murphy, K. R., & Fischer, M. (2008). ADHD in adults: What the science says. New York: Guilford Press.
Bhatia, S. K., Rezac, A. J., Vitiello, B., Sitorius, M. A., Buehler, B. A. & Kratochvil, C. J. (2008). Antidepressant prescribing practices for the treatment of children and adolescents. Journal of Child and Adolescent Psychopharmacology, 18(1), 70–80.
Biederman, J., Faraone, S., Monuteaux, M., & Grossbard, J. (2004). How informative are parent reports of ADHD symptoms for assessing outcome in clinical trials of long-acting treatments? A pooled analysis of parents’ and teachers’ reports. Pediatrics, 113(6), 1667–1671.
Birmaher, B. (1998). Should we use antidepressant medications for children and adolescents with depression? Psychopharmacology Bulletin, 34, 245–251.
Birmaher, B., & Brent, D. A. (2003). Antidepressants: II: Tricylic agents. In A. Martin, L. Scahill, D. S. Chaney, & J. F. Leckman (Eds.), Pediatric psychopharmacology: Principles and practice (pp. 466–483). New York: Oxford University Press.
Bohnstedt, B. N., Kronenberger, W. G., Dunn, D. W., Giaugue, A. L., Wood, E. A., Rembusch, M. E., et al. (2005). Investigator ratings of ADHD symptoms during a randomized trial of Atomoxetine: A comparison of parents and teachers as informants. Journal of Attention Disorders, 8(4), 153–159.
Bostic, J. Q., Prince, J., Frazier, J., DeJong, S., & Wilens, T. E. (2003). Pediatric psychopharmacology update. Psychiatric Times, 20, 9.
Brent, D., Emslie, G., Clarke, G., Wagner, K., Asarnow, J., Keller, M., et al. (2008). Switching to another SSRI or to Venlafaxine with and without cognitive behavioral therapy for adolescents with SSRI-resistant depression. JAMA, 299(8), 901–913.
Bridge, J. A., Iyengar, S., Salary, C. B., Barbe, R. P., Birmaher, B., Pincus, H. A., et al. (2007). Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: A meta-analysis of randomized controlled trials. JAMA, 297(15), 1683–1696.
Carlson, C. L., Pelham, W. E., Milich, R., & Dixon, M. (1992). Single and combined effects of methylphenidate and behavior therapy on the classroom behavior, academic performance, and self-evaluations of children with attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 202, 213–232.
Comings, D. E. (1990). Tourette syndrome and human behavior. Durante, CA; Hope Press.
Connor, D. F. (2006). Stimulants. In R.A. Barkley, Attention-deficit hyperactivity disorder: A handbook for diagnosis and treatment (3rd ed., pp. 608–647). New York: Guilford Press.
Corkum, P., Panton, R., Ironside, S., MacPherson, M., & Williams, T. (2008). Acute impact of immediate release methylphenidate administered three times a day on sleep in children with attention-deficit/hyperactivity disorder. Journal of Pediatric Psychology, 33(4), 368–379.
Doehring, D. G. (1968). Patterns of impairment in specific reading disability: A neuropsychological investigation. Bloomington: Indiana University Press.
Dubovsky, S. L. (1992). Psychopharmacological treatment in neuropsychiatry. In S. C. Yudofsky & R. E. Hales (Eds.), The American Psychiatric Press textbook of neuropsychiatry (2nd ed., pp. 663–702). Washington, DC: American Psychiatric Press.
DuPaul, G., & Stoner, Ga. (2003). ADHD in the schools: Assessment and intervention strategies (2nd ed.). New York: Guilford Press.
DuPaul, G., Barkley, R. A., & McMurphy, M. B. (1991). Therapeutic effects of medication on ADHD: Implications for school psychologists. School Psychology Review, 20,203–219.
DuPaul, G. J., McGoey, K. E., & Mautone, J. A. (2003). Pediatric pharmacology and psychopharmacology. In M. C. Roberts (Ed.), Handbook of pediatric psychology (3rd ed. pp. 234–252). New York: Guilford Press.
Faraone, S. V., Wigal, S. B., & Hodgins, P. (2007). Forecasting three-month outcomes in a laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and Atomoxetine (Stratttera) in school-aged children with ADHD. Journal of Attention Disorders, 11(1), 74–82.
Gadow, K. D., & Poling, A. G. (1988). Pharmacotherapy and mental retardation. Boston: College Hill Press.
Ghuman, J. K., Riddle, M. A., Vitiello, B., Greenhill, L. L., Ghuang, S., Wigal, S. et al. (2007). Comorbidity moderates response to methylphenidate in the preschoolers with attention deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology, 17(5), 563–580.
Gibbons, R. D., Hur, K., Bhaumik, D. K., & Mann, J.J. (2006). The relationship between antidepressant prescription rates and rate of early adolescent suicide. American Journal of Psychiatry 163, 1898–1904.
Green, W. H. (1991). Child and adolescent clinical psychopharmacology. Baltimore, MD: Williams & Wilkins.
Greenhill, L., Kollins, S., Abikoff, H., McCracken, J., Riddle, M., Swanson, J., et al. (2006). Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. Journal of the American Academy of Child & Adolescent Psychiatry. 45(11), 1284–1293.
Handen, B. L., & Gilchrist, R. (2006). Practitioner review: Psychopharmacology in children with mental retardation. Journal of Child Psychology and Psychiatry, 47(9), 871–882.
Hasler, G., Fromm, S., Carlson, P. J., Luckenbaugh, D. A., Waldeck ,T., Geraci, M.,et al. (2008). Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects. Archives of General Psychiatry, 65(5), 521–531.
Hinshaw, S. P. (1991). Stimulant medication and the treatment of aggression in children with attention deficits. Journal of Clinical Child Psychology, 20, 301–312.
Hinshaw, S. P., Henker, B., Whalen, C. K., Erhardt, D., & Dunnington, R. E. (1989). Aggressive, prosocial, and nonsocial behavior in hyperactive boys: Dose effects of methylphenidate in naturalistic settings. Journal of Consulting and Clinical Psychology, 57, 636–443.
Hunt, R. D., Mandl, L., Lau, S., & Hughes, M. (1991). Neurobiological theories of ADHD and Ritalin. In L. Greenhill (Ed.), Ritalin theory and practice (pp. 267–287). New York: Mary Ann Leibert Press
Jacobvitz, D., Sroufe, L. A., Stewart, M., & Leffert, N. (1990). Treatment of attentional and hyperactivity problems in children with sympathomimetic drugs: A comprehensive review. Journal of the American Academy of Child & Adolescent Psychiatry. 29(5), 677–688.
Joshi, P. T., Cappozzoli, J. A., & Coyle, J. T. (1988). Low-dose neuroleptic therapy for children with child-onset pervasive developmental disorder. American Journal of Psychiatry, 145,335–338.
Kelsey, D. K., Sumner, C. R., Casat, C. D., Coury, D. L., Quintana, H., Saylor, K. E., et al. (2004). Once-daily Atomoxetine treatment for children with attention-deficit/hyperactivity disorder, including an assessment of evening and morning behavior: A double-blind, placebo controlled trial. Pediatrics, 114 (1), e1–e8.
Kratochvil, C., Heiligenstein, J., Dittmann, R., Spencer, T. J., Biederman, J., Wernicke, J., et al. (2002). Atomoxetine and methylphenidate treatment in children with ADHD: A prospective, randomized, open-label trial. Journal of the American Academy of Child & Adolescent Psychiatry. 41(7), 776–784.
McGough, J. J., Wigal, S., Abikoff, H., Turnbow, J. M., Posner, K., & Moon, E. (2006). A randomized, double-blind, placebo-controlled, laboratory classroom assessment of methylphenidate transdermal system in children with ADHD. Journal of Attention Disorders, 9(3), 476–485.
MTA Cooperative Group. (2004a). National Institute of Mental Health Multimodal Treatment Study of Attention-deficit/hyperactivity disorder. Pediatrics, 113, 754–761.
MTA Cooperative Group. (2004b). National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: Changes in effectiveness and growth after the end of treatment. Pediatrics, 113, 762–769.
MTA Cooperative Group. (2008a). Evidence, interpretation, and qualification from multiple reports of long-term outcomes in the Multimodal Treatment Study of Children with AD/HD (MTA): Part I: Executive summary. Journal of Attention Disorders, 12(1), 3–13.
MTA Cooperative Group. (2008b). Evidence, interpretation, and qualification from multiple reports of long-term outcomes in the Multimodal Treatment Study of Children with AD/HD (MTA): Part II: Supporting details. Journal of Attention Disorders, 12(1), 14–41.
MTA Research Symposium (2007, November). Key impact of the MTA study: What is the take-home message. Paper presented at the 20th Anniversary Hall of Fame Conference, CHADD. Crystal City, VA.
Neppe, V. M., & Tucker, G. J. (1992). Neuropsychiatric aspects of seizure disorders. In S. C. Yudofsky & R. E. Hales (Eds.), The American Psychiatric Press textbook of neuropsychiatry (2nd ed., pp. 397–425). Washington, DC: American Psychiatric Press.
NIMH. (2007). Medications with Adendum January 2007. Department of Health and Human Services. National Institute of Health.
Olfson M., Marcus S. C., & Shaffer D. (2006). Antidepressant drug therapy and suicide in severely depressed children and adults. Archives of General Psychiatry, 63, 865–872.
Pelham, W. E. (1993). Pharmacotherapy for children with attention deficit-hyperactivity disorder. School Psychology Review, 22, 1–227.
Pelham, W. E., Schnedler, R, W., Bender, M. E., Nilsson, D. E., Miller, J., Budrow, M. S., et al. (1988). The combination of behavior therapy and methylphenidate in the treatment of attention deficit disorders. In L. Bloomingdale (Eds.), Attention deficit disorder (Vol. 3, pp. 29–48). New York: Pergamon Press.
Pellock, J. M. (1987). Carbamazepine side effects in children and adults. Epilepsia, 28, S64–S70.
Phelps, L., Brown, R. T., & Power, T. J. (2002). Pediatric psychopharmacology: Combining medical and psychosocial interventions.NY: Guilford Press.
Pliszka, S. R. (2003). Neuroscience of mental health clinicians. New York: Guilford Press.
Pliszka, S. R., Carlson, C. L., & Swanson, J. M. (1999). ADHD with comorbid disorders. New York: Guilford Press.
Rush, A. J., Fava, M., Wisniewski, S. R., Lavori, P. W., Trivedi, M. H., Sackeim, H. A., et al. (2004). Sequenced treatment alternatives to relieve depression (STAR*D): Rationale and design. Controlled Clinical Trials, 25(1), 119–142.
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A., Stewart, J. W., Warden, D., et al. (2006). Acute and longer-term outcomes in depressed outpatients who required one or several treatment steps: A STAR*D report. American Journal of Psychiatry, 163(11), 1905–1917.
Salzman, C. (1990). Benzodiazepine dependency: Summary of the APA task force on benzodiapines. Psychopharmacology Bulletin, 26, 61–62.
Safer, D. (2006). Should selective serotonin reuptake inhibitors be prescribed for children with major depressive and anxiety disorders? Pediatrics, 118(3), 1248–1251.
Schaughency, E. A., & Hynd, G. W. (1989). Attentional control systems and the attentional deficit disorders (ADD). Learning and Individual Differences, 4, 42–449.
Scheffer, R. E., Kowatch, R. A., Carmody, T., & Rush, A. J. (2005). Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium. American Journal of Psychiatry, 162(1):58–64.
Silva, R. R., Munoz, D. M., & Alpert, M. (1996). Carbamazepine use in children: Adolescents with features of attention-deficit hyperactivity disorders: A meta-analysis. The American Academy of Child and Adolescent Psychiatry, 35(3), 352–358.
Simon, G. E., Savarino, J., Operskalski, B., & Wang, P. (2006). Suicide risk during antidepressant treatment. American Journal of Psychiatry, 163(1), 41–47.
Swanson, J., Greenhill, L. L., Wigal, T., Kollins, S., Stehli, A. M., Davies, M., et al. (2006). Stimulant-related reductions of growth rates in the PATS. Journal of Child and Adolescent Psychopharmacology, 45(11), 1304–1313.
Treatment for Adolescents with Depression Study (TADS) Team. (2004). Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial. Journal of the American Medical Association, 292(7):807–820.
Taylor, E. Anderson, P., Banaschewski, T., Buitelaar, J., Coghill, D., Dopfner, M., et al. (2004). Clinical guidelines for hyperkinetic disorder. European Child and Adolescent Psychiatry, 13(Suppl. 1), 17–130.
US Food & Drug Administration. (2004). Background on suicidality associated with antidepressant drug treatment. Retrieved from www.fda.gov/ohrms/dockets/ac/04/briefing/2004-4065b1-04-Tab02-Laughren-Jan5.pdf
Vetter, V. L., Elia, J., Erickson, C., Berger, S., Nathan Blum, N., Uzark, K., et al. (2008). Cardiovascular monitoring of children and adolescents with heart disease receiving medications for attention deficit/hyperactivity disorder: A scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young Congenital Cardiac Defects Committee and the Council on Cardiovascular Nursing. Circulation; 117, 2407–2423.
Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Franceschi, D., Maynard, L., et al. (2002). Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implications. Synapse, 43, 181–187.
Weissman, M. M., Pilowsky, D. J., Wickramaratne, P. J., Talati, A., Wisniewski, S. R., Fava, M., et al. (2006). Remission in maternal depression and child psychopathology: A STAR*D-Child report. JAMA, 295, 1389–1398.
Weizman, A., Weitz, R., Szekely, G. A., Tyana, S., & Belmaker, R. H. (1984). Combination of neuroleptic and stimulant treatment in attention deficit disorder with hyperactivity. Journal of American Academy of Child Psychiatry, 23,295–298.
Wilens, T. E. (2001). Straight talk about psychiatric medications for kids. New York: Guilford Press.
Wilens, T. E., & Spencer, T. J. (1999). Debate: Combining methylphenidate and clonidine: A clinically sound medication option. Journal of the Child and Adolescent Psychiatry, 38, 614–622.
Wilens, T. E., & Spencer, T. J. (2000). The stimulants revisited. Child and Adolescent Psychiatric Clinics of North America, 9(3), 573–603.
Wood, J. G., Crager, J. L., Delap, C. M., & Heiskell, K. D. (2007). Beyond methylphenidate: Nonstimulant medications for youths with ADHD. Journal of Attention Disorders, 11(3), 341–350.
Zametkin, A. J., & Liotta W. (1998). The neurobiology of attention-deficit/hyperactivity disorder. Journal of Clinical Psychiatry, 59(Suppl 7), 17–23.
Zametkin, A. J., & Rapoport, J. L. (1986). The pathophysiology of attention deficit disorder with hyperactivity. In B. B. Lahey & A. E. Kazdin (Eds.), Advances in clinical child psychology (Vol. 9, pp. 177–216). New York: Plenum Press.
Zametkin, A., & Rapoport, J. L. (1987). Noradrenergic hypothesis of attention deficit disorder with hyperactivity: A critical review. In H. Y. Meltzer (Ed.), Psychopharmacology: The third generation of progress (pp. 837–842). New York: Raven Press.
Zametkin, A., Rapoport, J. L., Murphy, D. L., Linnoila, M., & Ismond, D. (1985). Treatment of hyperactive children with monamine oxidase inhibitors: I. Clinical efficacy. Archives of General Psychiatry, 42, 962–966.
Zisook, S., Lesser, I., Stewart, J. W., Wisniewski, S. R., Balasubramani, G. K., Fava, M., et al. (2007). Effect of age at onset on the course of major depressive disorder. American Journal of Psychiatry 164, 1539–1546.
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Semrud-Clikeman, M., Ellison, P.A.T. (2009). Pediatric Psychopharmacological and Combined Interventions. In: Child Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-88963-4_17
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