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Tropomyosin Gene Expression in Vivo and in Vitro

  • Chapter
Tropomyosin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 644))

Abstract

The evolution from unicellular to multicellular organisms of increasing complexity is paralleled by increased numbers of tropomyosin (Tm) genes and increasing numbers of isoforms encoded by each gene. The regulation of Tm isoform expression is intimately associated with the morphological changes that take place during development and cell differentiation. The tissue- and cell-specific Tm expression patterns are regulated at multiple levels, allowing precise spatial and temporal regulation of Tm expression. In this chapter, we review the Tm isoform expression pattern during differentiation of different tissue types and from this data infer some general principles regarding Tm expression patterns during differentiation. Finally, we review the mechanisms that account for the highly regulated repertoire of Tm isoform expression.

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Authors and Affiliations

  1. Oncology Research Unit, The Children’s Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia

    Galina Schevzov & Geraldine O’Neill

  2. Discipline of Paediatrics and Child Health, University of Sydney, Sydney, NSW, 2006, Australia

    Galina Schevzov & Geraldine O’Neill

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  1. Galina Schevzov
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  2. Geraldine O’Neill
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Correspondence to Galina Schevzov .

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  1. Oncology Research Unit, Department of Pharmacology School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia

    Peter Gunning PhD

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Schevzov, G., O’Neill, G. (2008). Tropomyosin Gene Expression in Vivo and in Vitro. In: Gunning, P. (eds) Tropomyosin. Advances in Experimental Medicine and Biology, vol 644. Springer, New York, NY. https://doi.org/10.1007/978-0-387-85766-4_4

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