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Epigenetic Mouse Models

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Genetically Engineered Mice for Cancer Research

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Abstract

Epigenetics may be defined as the study of the heritable changes in gene activity that cannot be explained by changes in DNA sequences. Epigenetic modifications include many chemical marks, but there are two major mechanisms regulating epigenetic changes: DNA methylation and histone modifications. In the current chapter, we review studies using mouse models targeting genes involved in the establishment of the epigenetic marks (such as DNA methyltransferases, histone deacetylases or demethylases) and the interpretation of the significance of these alterations (such as methyl-CpG binding domain proteins) in understanding disease processes.

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Authors and Affiliations

  1. Cancer Epigenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

    Cecilia Rosales & Manel Esteller

  2. Cancer Epigenetics and Biology Program (PEBC), Catalan Institute of Oncology (ICO), Barcelona, Catalonia, Spain

    Cecilia Rosales & Manel Esteller

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  1. Cecilia Rosales
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  2. Manel Esteller
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Correspondence to Manel Esteller .

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  1. , Laboratory Of Cancer Biology and Genetic, National Cancer Institute, Convent Dr. 37, Bethesda, 20892, Maryland, USA

    Jeffrey E. Green

  2. National Cancer Institute, Center for Cancer Research, National Institutes of Health, South Drive 50, Bethesda, 20892, Maryland, USA

    Thomas Ried

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Rosales, C., Esteller, M. (2012). Epigenetic Mouse Models. In: Green, J., Ried, T. (eds) Genetically Engineered Mice for Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69805-2_18

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