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Developmental, Behavioral, and Physiological Phenotype of Cloned Mice

  • Chapter
Somatic Cell Nuclear Transfer

Part of the book series: Advances in Experimental Medicine and Biology ((volume 591))

Abstract

Cloning from adult somatic cells has been successful in at least ten species. Although generating viable cloned mammals from adult cells is technically feasible, prenatal and perinatal mortality is high and live cloned offspring have had health problems. This chapter summarizes the health consequences of cloning in mice and discusses possible mechanisms through which these conditions may arise. These studies have further significance as other assisted reproductive techniques (ART) also involve some of the same procedures used in cloning, and there are some reports that offspring generated by ART display aberrant phenotypes as well. At the moment, the long-term consequences of mammalian cloning remain poorly characterized. Data available thus far suggest that we should use this technology with great caution until numerous questions are addressed and answered.

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Author information

Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, Maryland, 21205, USA

    Kellie L. K. Tamashiro

  2. Neuroscience Program, Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Onio, USA

    Kellie L. K. Tamashiro & Randall R. Sakai

  3. Institute for Biogenesis Research, University of Hawaii School of Medicine, Honolulu, Hawaii, USA

    Yukiko Yamazaki, Teruhiko Wakayama & Ryuzo Yanagimachi

  4. Laboratory for Genomic Reprogramming, Center for Developmental Biology, RIKEN Kobe, Chuo-ku, Kobe, Japan

    Teruhiko Wakayama

Authors
  1. Kellie L. K. Tamashiro
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  2. Randall R. Sakai
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  3. Yukiko Yamazaki
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  4. Teruhiko Wakayama
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  5. Ryuzo Yanagimachi
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Editor information

Editors and Affiliations

  1. Department of Animal Science, University of Missouri-Columbia, Columbia, Missouri, USA

    Peter Sutovsky Ph.D.

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© 2007 Landes Bioscience and Springer Science+Business Media

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Tamashiro, K.L.K., Sakai, R.R., Yamazaki, Y., Wakayama, T., Yanagimachi, R. (2007). Developmental, Behavioral, and Physiological Phenotype of Cloned Mice. In: Sutovsky, P. (eds) Somatic Cell Nuclear Transfer. Advances in Experimental Medicine and Biology, vol 591. Springer, New York, NY. https://doi.org/10.1007/978-0-387-37754-4_5

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