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Nuclear Remodeling and Nuclear Reprogramming for Making Transgenic Pigs by Nuclear Transfer

  • Chapter
Somatic Cell Nuclear Transfer

Part of the book series: Advances in Experimental Medicine and Biology ((volume 591))

Abstract

A better understanding of the cellular and molecular events that occur when a nucleus is transferred to the cytoplasm of an oocyte will permit the development of improved procedures for performing nuclear transfer and cloning. In some cases it appears that the gene(s) are reprogrammed, while in other cases there appears to be little effect on gene expression. Not only does the pattern of gene expression need to be reprogrammed, but other structures within the nucleus also need to be remodeled. While nuclear transfer works and transgenic and knockout animals can be created, it still is an inefficient process. However, even with the current low efficiencies this technique has proved very valuable for the production of animals that might be useful for tissue or organ transplantation to humans.

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  1. Division of Animal Science, Food for the 21st Century, College of Food, Agriculture & Natural Resources, University of Missouri-Columbia, 920 East Campus Drive, E125 ASRC, Columbia, Missouri, 65211-5300, USA

    Randall S. Prather

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  1. Department of Animal Science, University of Missouri-Columbia, Columbia, Missouri, USA

    Peter Sutovsky Ph.D.

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© 2007 Landes Bioscience and Springer Science+Business Media

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Prather, R.S. (2007). Nuclear Remodeling and Nuclear Reprogramming for Making Transgenic Pigs by Nuclear Transfer. In: Sutovsky, P. (eds) Somatic Cell Nuclear Transfer. Advances in Experimental Medicine and Biology, vol 591. Springer, New York, NY. https://doi.org/10.1007/978-0-387-37754-4_1

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