Skip to main content
SpringerLink
Log in

Nerve Growth Factor Regulated Gene Expression

  • Reference work entry
Handbook of Neurochemistry and Molecular Neurobiology

Abstract:

This chapter provides a current accounting of the identities of genes and gene products that are subject to long-term regulation by nerve growth factor (NGF). We provide tabular listings of (a) NGF-responsive genes and proteins that are reported in the literature and (b) transcripts found by comprehensive serial analysis of gene expression (SAGE) to be differentially expressed in PC12 cells before and after long-term NGF exposure. Transcriptional changes are key elements in the mechanisms by which NGF affects neuronal differentiation, function, protection, and repair. The information provided here is thus meant to serve as a resource for those interested in the molecular mechanisms and consequences of trophic factor actions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 249.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

ATF5:

activating transcription factor 5

EST:

expressed sequence tag

NGF:

nerve growth factor

SAGE:

serial analysis of gene expression

References

  • Aletta JM, Angeletti R, Liem RK, Purcell C, Shelanski ML, et al. 1988. Relationship between the nerve growth factor-regulated clone 73 gene product and the 58-kilodalton neuronal intermediate filament protein (peripherin). J Neurochem 51: 1317–1320.

    CAS  PubMed  Google Scholar 

  • Alheim K, McDowell TL, Symons JA, Duff GW, Bartfai T. 1996. An AP-1 site is involved in the NGF induction of IL-1 alpha in PC12 cells. Neurochem Int 29: 487–496.

    CAS  PubMed  Google Scholar 

  • Allen JM, Martin JB, Heinrich G. 1987. Neuropeptide Y gene expression in PC12 cells and its regulation by nerve growth factor: A model for developmental regulation. Brain Res 427: 39–43.

    CAS  PubMed  Google Scholar 

  • Anastasiadis PZ, Kuhn DM, Blitz J, Imerman BA, Louie MC, et al. 1996. Regulation of tyrosine hydroxylase and tetrahydrobiopterin biosynthetic enzymes in PC12 cells by NGF, EGF and IFN-gamma. Brain Res 713: 125–133.

    CAS  PubMed  Google Scholar 

  • Angelastro JM, Klimaschewski L, Tang S, Vitolo OV, Weissman TA, et al. 2000. Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling. Proc Natl Acad Sci USA 97: 10424–10429.

    CAS  PubMed  Google Scholar 

  • Angelastro JM, Ignatova TN, Kukekov VG, Steindler DA, Stengren GB, et al. 2003. Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons. J Neurosci 23: 4590–4600.

    CAS  PubMed  Google Scholar 

  • Angelastro JM, Mason JL, Ignatova TN, Kukekov VG, Stengren GB, et al. 2005. Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes. J Neurosci 25: 3889–3899.

    CAS  PubMed  Google Scholar 

  • Apfel SC, Wright DE, Wiideman AM, Dormia C, Snider WD, et al. 1996. Nerve growth factor regulates the expression of brain-derived neurotrophic factor mRNA in the peripheral nervous system. Mol Cell Neurosci 7: 134–142.

    CAS  PubMed  Google Scholar 

  • Araki T, Nagarajan R, Milbrandt J. 2001. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. J Biol Chem 276: 34131–34141.

    CAS  PubMed  Google Scholar 

  • Arslan G, Kontny E, Fredholm BB. 1997. Down-regulation of adenosine A2A receptors upon NGF-induced differentiation of PC12 cells. Neuropharmacology 36: 1319–1326.

    CAS  PubMed  Google Scholar 

  • Avila AM, Davila-Garcia MI, Ascarrunz VS, Xiao Y, Kellar KJ. 2003. Differential regulation of nicotinic acetylcholine receptors in PC12 cells by nicotine and nerve growth factor. Mol Pharmacol 64: 974–986.

    CAS  PubMed  Google Scholar 

  • Badoyannis HC, Sharma SC, Sabban EL. 1991. The differential effects of cell density and NGF on the expression of tyrosine hydroxylase and dopamine beta-hydroxylase in PC12 cells. Brain Res Mol Brain Res 11: 79–87.

    CAS  PubMed  Google Scholar 

  • Bai G, Weiss B. 1991. The increase of calmodulin in PC12 cells induced by NGF is caused by differential expression of multiple mRNAs for calmodulin. J Cell Physiol 149: 414–421.

    CAS  PubMed  Google Scholar 

  • Bai J, Nakamura H, Kwon YW, Hattori I, Yamaguchi Y, et al. 2003. Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells. J Neurosci 23: 503–509.

    CAS  PubMed  Google Scholar 

  • Biswas SC, Greene LA. 2002. Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation. J Biol Chem 277: 49511–49516.

    CAS  PubMed  Google Scholar 

  • Black JA, Langworthy K, Hinson AW, Dib-Hajj SD, Waxman SG. 1997. NGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons. Neuroreport 8: 2331–2335.

    CAS  PubMed  Google Scholar 

  • Boettger MK, Till S, Chen MX, Anand U, Otto WR, et al. 2002. Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors. Brain 125: 252–263.

    CAS  PubMed  Google Scholar 

  • Bournat JC, Allen JM. 2001. Regulation of the Y1 neuropeptide Y receptor gene expression in PC12 cells. Brain Res Mol Brain Res 90: 149–164.

    CAS  PubMed  Google Scholar 

  • Bu G, Sun Y, Schwartz AL, Holtzman DM. 1998. Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein. J Biol Chem 273: 13359–13365.

    CAS  PubMed  Google Scholar 

  • Buchkovich KJ, Ziff EB. 1994. Nerve growth factor regulates the expression and activity of p33cdk2 and p34cdc2 kinases in PC12 pheochromocytoma cells. Mol Biol Cell 5: 1225–1241.

    CAS  PubMed  Google Scholar 

  • Burstein DE, Greene LA. 1978. Evidence for RNA synthesis-dependent and - independent pathways in stimulation of neurite outgrowth by nerve growth factor. Proc Natl Acad Sci USA 75: 6059–6063.

    CAS  PubMed  Google Scholar 

  • Caillaud T, Opstal WY, Scarceriaux V, Billardon C, Rostene W. 1995. Treatment of PC12 cells by nerve growth factor, dexamethasone, and forskolin. Effects on cell morphology and expression of neurotensin and tyrosine hydroxylase. Mol Neurobiol 10: 105–114.

    CAS  PubMed  Google Scholar 

  • Calissano P, Volonte C, Biocca S, Cattaneo A. 1985. Synthesis and content of a DNA-binding protein with lactic dehydrogenase activity are reduced by nerve growth factor in the neoplastic cell line PC12. Exp Cell Res 161: 117–129.

    CAS  PubMed  Google Scholar 

  • Carter JM, Waite KA, Campenot RB, Vance JE, Vance DE. 2003. Enhanced expression and activation of CTP: Phosphocholine cytidylyltransferase beta2 during neurite outgrowth. J Biol Chem 278: 44988–44994.

    CAS  PubMed  Google Scholar 

  • Cavallaro S, D'Agata V, Guardabasso V, Travali S, Stivala F, et al. 1995. Differentiation induces pituitary adenylate cyclase-activating polypeptide receptor expression in PC-12 cells. Mol Pharmacol 48: 56–62.

    CAS  PubMed  Google Scholar 

  • Cavicchioli L, Flanigan TP, Vantini G, Fusco M, Polato P, et al. 1989. NGF amplifies expression of NGF receptor messenger RNA in forebrain cholinergic neurons of rats. Eur J Neurosci 1: 258–262.

    PubMed  Google Scholar 

  • Chang A, Toloza E, Bulinski JC. 1986. Changes in the expression of beta and gamma actins during differentiation of PC12 cells. J Neurochem 47: 1885–1892.

    CAS  PubMed  Google Scholar 

  • Chao CC, Su LJ, Sun NK, Ju YT, Lih JC, et al. 2003. Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells. J Neurosci Res 74: 248–254.

    CAS  PubMed  Google Scholar 

  • Chen J, Liu T, Ross AH. 1994. Down-regulation of c-myc oncogene during NGF-induced differentiation of neuroblastoma cell lines. Chin Med Sci J 9: 152–156.

    CAS  PubMed  Google Scholar 

  • Cisneros B, Rendon A, Genty V, Aranda G, Marquez F, et al. 1996. Expression of dystrophin Dp71 during PC12 cell differentiation. Neurosci Lett 213: 107–110.

    CAS  PubMed  Google Scholar 

  • Colston JT, Valdes JJ, Chambers JP. 1998. Ca2+ channel alpha 1-subunit transcripts are differentially expressed in rat pheochromocytoma (PC12) cells following nerve growth factor treatment. Int J Dev Neurosci 16: 379–389.

    CAS  PubMed  Google Scholar 

  • Corcoran J, Maden M. 1999. Nerve growth factor acts via retinoic acid synthesis to stimulate neurite outgrowth. Nat Neurosci 2: 307–308.

    CAS  PubMed  Google Scholar 

  • Corness J, Stevens B, Fields RD, Hokfelt T. 1998. NGF and LIF both regulate galanin gene expression in primary DRG cultures. Neuroreport 9: 1533–1536.

    CAS  PubMed  Google Scholar 

  • Cosgaya JM, Aranda A. 2001. Nerve growth factor activates the RARbeta2 promoter by a Ras-dependent mechanism. J Neurochem 76: 661–671.

    CAS  PubMed  Google Scholar 

  • Costello B, Meymandi A, Freeman JA. 1990. Factors influencing GAP-43 gene expression in PC12 pheochromocytoma cells. J Neurosci 10: 1398–1406.

    CAS  PubMed  Google Scholar 

  • D'Arcangelo G, Paradiso K, Shepherd D, Brehm P, Halegoua S, et al. 1993. Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways. J Cell Biol 122: 915–921.

    PubMed  Google Scholar 

  • Danker K, Mechai N, Lucka L, Reutter W, Horstkorte R. 2001. The small Gtpase ras is involved in growth factor-regulated expression of the alpha1 integrin subunit in PC12 cells. Biol Chem 382: 969–972.

    CAS  PubMed  Google Scholar 

  • De Leon M, Nahin RL, Mendoza ME, Ruda MA. 1994. SR13/PMP-22 expression in rat nervous system, in PC12 cells, and C6 glial cell lines. J Neurosci Res 38: 167–181.

    CAS  PubMed  Google Scholar 

  • Deng J, Szyf M. 1998. Multiple isoforms of DNA methyltransferase are encoded by the vertebrate cytosine DNA methyltransferase gene. J Biol Chem 273: 22869–22872.

    CAS  PubMed  Google Scholar 

  • Deschenes-Furry J, Belanger G, Perrone-Bizzozero N, Jasmin BJ. 2003. Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD. J Biol Chem 278: 5710–5717.

    CAS  PubMed  Google Scholar 

  • Dobashi Y, Bhattacharjee RN, Toyoshima K, Akiyama T. 1996. Upregulation of the APC gene product during neuronal differentiation of rat pheochromocytoma PC12 cells. Biochem Biophys Res Commun 224: 479–483.

    CAS  PubMed  Google Scholar 

  • Doherty P, Mann DA, Walsh FS. 1988. Comparison of the effects of NGF, activators of protein kinase C, and a calcium ionophore on the expression of Thy-1 and N-CAM in PC12 cell cultures. J Cell Biol 107: 333–340.

    CAS  PubMed  Google Scholar 

  • Drubin DG, Feinstein SC, Shooter EM, Kirschner MW. 1985. Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. J Cell Biol 101: 1799–1807.

    CAS  PubMed  Google Scholar 

  • Ebstein RP, Bennett ER, Sokoloff M, Shoham S. 1993. The effect of nerve growth factor on cholinergic cells in primary fetal striatal cultures: Characterization by in situ hybridization. Brain Res Dev Brain Res 73: 165–172.

    CAS  PubMed  Google Scholar 

  • Eva C, Fusco M, Bono C, Tria MA, Ricci Gamalero S, et al. 1992. Nerve growth factor modulates the expression of muscarinic cholinergic receptor messenger RNA in telencephalic neuronal cultures from newborn rat brain. Brain Res Mol Brain Res 14: 344–351.

    CAS  PubMed  Google Scholar 

  • Farias-Eisner R, Vician L, Silver A, Reddy S, Rabbani SA, et al. 2000. The urokinase plasminogen activator receptor (UPAR) is preferentially induced by nerve growth factor in PC12 pheochromocytoma cells and is required for NGF-driven differentiation. J Neurosci 20: 230–239.

    CAS  PubMed  Google Scholar 

  • Farias-Eisner R, Vician L, Reddy S, Basconcillo R, Rabbani SA, et al. 2001. Expression of the urokinase plasminogen activator receptor is transiently required during “priming” of PC12 cells in nerve growth factor-directed cellular differentiation. J Neurosci Res 63: 341–346.

    CAS  PubMed  Google Scholar 

  • Feinstein SC, Dana SL, McConlogue L, Shooter EM, Coffino P. 1985. Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells. Proc Natl Acad Sci USA 82: 5761–5765.

    CAS  PubMed  Google Scholar 

  • Fischer I, Richter-Landsberg C, Safaei R. 1991. Regulation of microtubule associated protein 2 (MAP2) expression by nerve growth factor in PC12 cells. Exp Cell Res 194: 195–201.

    CAS  PubMed  Google Scholar 

  • Forander P, Broberger C, Stromberg I. 2001. Glial-cell-line-derived neurotrophic factor induces nerve fibre formation in primary cultures of adrenal chromaffin cells. Cell Tissue Res 305: 43–51.

    CAS  PubMed  Google Scholar 

  • Frim DM, Wullner U, Beal MF, Isacson O. 1994. Implanted NGF-producing fibroblasts induce catalase and modify ATP levels but do not affect glutamate receptor binding or NMDA receptor expression in the rat striatum. Exp Neurol 128: 172–180.

    CAS  PubMed  Google Scholar 

  • Furnish EJ, Zhou W, Cunningham CC, Kas JA, Schmidt CE. 2001. Gelsolin overexpression enhances neurite outgrowth in PC12 cells. FEBS Lett 508: 282–286.

    CAS  PubMed  Google Scholar 

  • Gallo R, Zazzeroni F, Alesse E, Mincione C, Borello U, et al. 2002. REN: A novel, developmentally regulated gene that promotes neural cell differentiation. J Cell Biol 158: 731–740.

    CAS  PubMed  Google Scholar 

  • Ghassemi F, Dib-Hajj SD, Waxman SG. 2001. Beta1 adducin gene expression in DRG is developmentally regulated and is upregulated by glial-derived neurotrophic factor and nerve growth factor. Brain Res Mol Brain Res 90: 118–124.

    CAS  PubMed  Google Scholar 

  • Gibbs TC, Meier KE. 2000. Expression and regulation of phospholipase D isoforms in mammalian cell lines. J Cell Physiol 182: 77–87.

    CAS  PubMed  Google Scholar 

  • Gollapudi L, Neet KE. 1997. Different mechanisms for inhibition of cell proliferation via cell cycle proteins in PC12 cells by nerve growth factor and staurosporine. J Neurosci Res 49: 461–474.

    CAS  PubMed  Google Scholar 

  • Grant NJ, Claudepierre T, Aunis D, Langley K. 1996. Glucocorticoids and nerve growth factor differentially modulate cell adhesion molecule L1 expression in PC12 cells. J Neurochem 66: 1400–1408.

    CAS  PubMed  Google Scholar 

  • Greenberg ME, Greene LA, Ziff EB. 1985. Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem 260: 14101–14110.

    CAS  PubMed  Google Scholar 

  • Greene LA, Rukenstein A. 1981. Regulation of acetylcholinesterase activity by nerve growth factor. Role of transcription and dissociation from effects on proliferation and neurite outgrowth. J Biol Chem 256: 6363–6367.

    CAS  PubMed  Google Scholar 

  • Greene LA, Liem RK, Shelanski ML. 1983. Regulation of a high molecular weight microtubule-associated protein in PC12 cells by nerve growth factor. J Cell Biol 96: 76–83.

    CAS  PubMed  Google Scholar 

  • Greene LA, Bernd P, Black MM, Burstein DE, Connolly JL, et al. 1983. Genomic and non-genomic actions of nerve growth factor in development. Prog Brain Res 58: 347–357.

    CAS  PubMed  Google Scholar 

  • Grumolato L, Louiset E, Alexandre D, Ait-Ali D, Turquier V, et al. 2003. PACAP and NGF regulate common and distinct traits of the sympathoadrenal lineage: Effects on electrical properties, gene markers and transcription factors in differentiating PC12 cells. Eur J Neurosci 17: 71–82.

    PubMed  Google Scholar 

  • Gutacker C, Klock G, Diel P, Koch-Brandt C. 1999. Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells. Biochem J 339 (Pt 3): 759–766.

    CAS  PubMed  Google Scholar 

  • Hashimoto H, Hagihara N, Koga K, Yamamoto K, Shintani N, et al. 2000. Synergistic induction of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression by nerve growth factor and PACAP in PC12 cells. J Neurochem 74: 501–507.

    CAS  PubMed  Google Scholar 

  • Hayakawa K, Nakashima S, Ito Y, Mizuta K, Miyata H, et al. 1999. Increased expression of phospholipase D1 mRNA during cAMP- or NGF-induced differentiation in PC12 cells. Neurosci Lett 265: 127–130.

    CAS  PubMed  Google Scholar 

  • Heese K, Nagai Y, Sawada T. 2004. Nerve growth factor (NGF) induces mRNA expression of the new transcription factor protein p48ZnF. Exp Mol Med 36: 130–134.

    CAS  PubMed  Google Scholar 

  • Henderson LP, Gdovin MJ, Liu C, Gardner PD, Maue RA. 1994. Nerve growth factor increases nicotinic ACh receptor gene expression and current density in wild-type and protein kinase A-deficient PC12 cells. J Neurosci 14: 1153–1163.

    CAS  PubMed  Google Scholar 

  • Hens J, Nuydens R, Geerts H, Senden NH, WJ, Van de Ven et al. 1998. Neuronal differentiation is accompanied by NSP-C expression. Cell Tissue Res 292: 229–237.

    CAS  PubMed  Google Scholar 

  • Higgins GA, Koh S, Chen KS, Gage FH. 1989. NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat. Neuron 3: 247–256.

    CAS  PubMed  Google Scholar 

  • Hirayama K, Kapatos G. 1995. Regulation of GTP cyclohydrolase I gene expression and tetrahydrobiopterin content by nerve growth factor in cultures of superior cervical ganglia. Neurochem Int 27: 157–161.

    CAS  PubMed  Google Scholar 

  • Holtzman DM, Lee S, Li Y, Chua-Couzens J, Xia H, et al. 1996. Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: Regulation by NGF. Neurochem Res 21: 861–868.

    CAS  PubMed  Google Scholar 

  • Huang XC, Shenoy UV, Richards EM, Sumners C. 1997. Modulation of angiotensin II type 2 receptor mRNA in rat hypothalamus and brainstem neuronal cultures by growth factors. Brain Res Mol Brain Res 47: 229–236.

    CAS  PubMed  Google Scholar 

  • Iacopino AM, Christakos S, Modi P, Altar CA. 1992. Nerve growth factor increases calcium binding protein (calbindin-D28K) in rat olfactory bulb. Brain Res 578: 305–310.

    CAS  PubMed  Google Scholar 

  • Ichikawa M, Kikuchi T, Tateiwa H, Gotoh N, Ohta K, et al. 2002. Role of PTB-like protein, a neuronal RNA-binding protein, during the differentiation of PC12 cells. J Biochem (Tokyo) 131: 861–868.

    CAS  Google Scholar 

  • Ikeda T, Kitayama S, Morita K, Dohi T. 2001. Nerve growth factor down-regulates the expression of norepinephrine transporter in rat pheochromocytoma (PC12) cells. Brain Res Mol Brain Res 86: 90–100.

    CAS  PubMed  Google Scholar 

  • Jacovina AT, Zhong F, Khazanova E, Lev E, Deora AB, et al. 2001. Neuritogenesis and the nerve growth factor-induced differentiation of PC-12 cells requires annexin II-mediated plasmin generation. J Biol Chem 276: 49350–49358.

    CAS  PubMed  Google Scholar 

  • Jameson HL, Lillycrop KA. 2001. Nerve growth factor induces the expression of the LIM homeodomain transcription factor Isl-1 with the kinetics of an immediate early gene in adult rat dorsal root ganglion. Neurosci Lett 309: 130–134.

    CAS  PubMed  Google Scholar 

  • Jongsma Wallin H, Danielsen N, Johnston JM, Gratto KA, Karchewski LA, et al. 2001. Exogenous NT-3 and NGF differentially modulate PACAP expression in adult sensory neurons, suggesting distinct roles in injury and inflammation. Eur J Neurosci 14: 267–282.

    CAS  PubMed  Google Scholar 

  • Joseph R, Tsang W, Dou D, Nelson K, Edvardsen K. 1996. Neuronatin mRNA in PC12 cells: Downregulation by nerve growth factor. Brain Res 738: 32–38.

    CAS  PubMed  Google Scholar 

  • Kane MD, Vanden Heuvel JP, Isom GE, Schwarz RD. 1998. Differential expression of group I metabotropic glutamate receptors (mGluRs) in the rat pheochromocytoma cell line PC12: Role of nerve growth factor and ras. Neurosci Lett 252: 1–4.

    CAS  PubMed  Google Scholar 

  • Kaplan MD, Olschowka JA, O'Banion MK. 1997. Cyclooxygenase-1 behaves as a delayed response gene in PC12 cells differentiated by nerve growth factor. J Biol Chem 272: 18534–18537.

    CAS  PubMed  Google Scholar 

  • Kim SJ, Park K, Rudkin BB, Dey BR, Sporn MB, et al. 1994. Nerve growth factor induces transcription of transforming growth factor-beta 1 through a specific promoter element in PC12 cells. J Biol Chem 269: 3739–3744.

    CAS  PubMed  Google Scholar 

  • Kleijn M, Welsh GI, Scheper GC, Voorma HO, Proud CG, et al. 1998. Nerve and epidermal growth factor induce protein synthesis and eIF2B activation in PC12 cells. J Biol Chem 273: 5536–5541.

    CAS  PubMed  Google Scholar 

  • Kobayashi H, Itoh S, Yanagita T, Yokoo H, Sugano T, et al. 2004. Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in PC12 cells after exposure to nerve growth factor. Neuroscience 125: 973–980.

    CAS  PubMed  Google Scholar 

  • Kojima M, Ikeuchi T, Hatanaka H. 1994. Nerve growth factor induces trkA mRNA expression in cultured basal forebrain cholinergic neurons from 17-day fetal rats. Neurosci Lett 169: 47–50.

    CAS  PubMed  Google Scholar 

  • Kuklinski S, Vladimirova V, Waha A, Kamata H, Pesheva P, et al. 2003. Expression of galectin-3 in neuronally differentiating PC12 cells is regulated both via Ras/MAPK-dependent and -independent signalling pathways. J Neurochem 87: 1112–1124.

    CAS  PubMed  Google Scholar 

  • Kurihara K, Hosoi K, Ueha T, Nakanishi N, Yamada S. 1994. Effects of nerve growth factor and dexamethasone on Na+,K(+)-ATPase of cultured PC12h cells. Horm Metab Res 26: 14–18.

    CAS  PubMed  Google Scholar 

  • Lah JJ, Burry RW. 1993. Neuronotypic differentiation results in reduced levels and altered distribution of synaptophysin in PC12 cells. J Neurochem 60: 503–512.

    CAS  PubMed  Google Scholar 

  • Laslop A, Tschernitz C. 1992. Effects of nerve growth factor on the biosynthesis of chromogranin A and B, secretogranin II and carboxypeptidase H in rat PC12 cells. Neuroscience 49: 443–450.

    CAS  PubMed  Google Scholar 

  • Lawlor KG, Narayanan R. 1992. Persistent expression of the tumor suppressor gene DCC is essential for neuronal differentiation. Cell Growth Differ 3: 609–616.

    CAS  PubMed  Google Scholar 

  • Lee NH, Malek RL. 1998. Nerve growth factor regulation of m4 muscarinic receptor mRNA stability but not gene transcription requires mitogen-activated protein kinase activity. J Biol Chem 273: 22317–22325.

    CAS  PubMed  Google Scholar 

  • Lee YJ, Zachrisson O, Tonge DA, McNaughton PA. 2002. Upregulation of bradykinin B2 receptor expression by neurotrophic factors and nerve injury in mouse sensory neurons. Mol Cell Neurosci 19: 186–200.

    CAS  PubMed  Google Scholar 

  • Leonard DG, Ziff EB, Greene LA. 1987. Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells. Mol Cell Biol 7: 3156–3167.

    CAS  PubMed  Google Scholar 

  • Levi A, Eldridge JD, Paterson BM. 1985. Molecular cloning of a gene sequence regulated by nerve growth factor. Science 229: 393–395.

    CAS  PubMed  Google Scholar 

  • Li XM, Qi J, Juorio AV, Boulton AA. 1997. Reciprocal regulation of the content of aromatic L-amino acid decarboxylase and tyrosine hydroxylase mRNA by NGF in PC12 cells. J Neurosci Res 47: 449–454.

    CAS  PubMed  Google Scholar 

  • Lindenbaum MH, Carbonetto S, Mushynski WE. 1987. Nerve growth factor enhances the synthesis, phosphorylation, and metabolic stability of neurofilament proteins in PC12 cells. J Biol Chem 262: 605–610.

    CAS  PubMed  Google Scholar 

  • Lindsay RM. 1988. Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons. J Neurosci 8: 2394–2405.

    CAS  PubMed  Google Scholar 

  • Lindsay RM, Harmar AJ. 1989. Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature 337: 362–364.

    CAS  PubMed  Google Scholar 

  • Lindsay RM, Shooter EM, Radeke MJ, Misko TP, Dechant G, et al. 1990. Nerve Growth Factor Regulates Expression of the Nerve Growth Factor Receptor Gene in Adult Sensory Neurons. Eur J Neurosci 2: 389–396.

    PubMed  Google Scholar 

  • Liu H, Force T, Bloch KD. 1997. Nerve growth factor decreases soluble guanylate cyclase in rat pheochromocytoma PC12 cells. J Biol Chem 272: 6038–6043.

    CAS  PubMed  Google Scholar 

  • Liu XW, Gong LJ, Guo LY, Katagiri Y, Jiang H, et al. 2001. The Wilms’ tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells. J Biol Chem 276: 5068–5073.

    CAS  PubMed  Google Scholar 

  • Ma Y, Campenot RB, Miller FD. 1992. Concentration-dependent regulation of neuronal gene expression by nerve growth factor. J Cell Biol 117: 135–141.

    CAS  PubMed  Google Scholar 

  • Machida CM, Rodland KD, Matrisian L, Magun BE, Ciment G. 1989. NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells. Neuron 2: 1587–1596.

    CAS  PubMed  Google Scholar 

  • Mahata SK, Mahata M, Wu H, Parmer RJ, O'Connor DT. 1999. Neurotrophin activation of catecholamine storage vesicle protein gene expression: Signaling to chromogranin a biosynthesis. Neuroscience 88: 405–424.

    CAS  PubMed  Google Scholar 

  • Mamet J, Lazdunski M, Voilley N. 2003. How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons. J Biol Chem 278: 48907–48913.

    CAS  PubMed  Google Scholar 

  • Mandel G, Cooperman SS, Maue RA, Goodman RH, Brehm P. 1988. Selective induction of brain type II Na+ channels by nerve growth factor. Proc Natl Acad Sci USA 85: 924–928.

    CAS  PubMed  Google Scholar 

  • Masiakowski P, Shooter EM. 1988. Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells. Proc Natl Acad Sci USA 85: 1277–1281.

    CAS  PubMed  Google Scholar 

  • Mason JL, Angelastro JM, Ignatova TN, Kukekov VG, Lin G, et al. 2005. ATF5 regulates the proliferation and differentiation of oligodendrocytes. Mol Cell Neurosci 29: 372–380.

    CAS  PubMed  Google Scholar 

  • Mathew TC, Miller FD. 1990. Increased expression of T alpha 1 alpha-tubulin mRNA during collateral and NGF-induced sprouting of sympathetic neurons. Dev Biol 141: 84–92.

    CAS  PubMed  Google Scholar 

  • Max SR, Rohrer H, Otten U, Thoenen H. 1978. Nerve growth factor-mediated induction of tyrosine hydroxylase in rat superior cervical ganglia in vitro. J Biol Chem 253: 8013–8015.

    CAS  PubMed  Google Scholar 

  • McGuire JC, Greene LA, Furano AV. 1978. NGF stimulates incorporation of fucose or glucosamine into an external glycoprotein in cultured rat PC12 pheochromocytoma cells. Cell 15: 357–365.

    CAS  PubMed  Google Scholar 

  • Mearow KM. 1998. The effects of NGF and sensory nerve stimulation on collateral sprouting and gene expression in adult sensory neurons. Exp Neurol 151: 14–25.

    CAS  PubMed  Google Scholar 

  • Meisinger C, Hertenstein A, Grothe C. 1996. Fibroblast growth factor receptor 1 in the adrenal gland and PC12 cells: Developmental expression and regulation by extrinsic molecules. Brain Res Mol Brain Res 36: 70–78.

    CAS  PubMed  Google Scholar 

  • Metheny LJ, Skuse GR. 1996. NF1 mRNA isoform expression in PC12 cells: Modulation by extrinsic factors. Exp Cell Res 228: 44–49.

    CAS  PubMed  Google Scholar 

  • Miller FD, Naus CC, Durand M, Bloom FE, Milner RJ. 1987. Isotypes of alpha-tubulin are differentially regulated during neuronal maturation. J Cell Biol 105: 3065–3073.

    CAS  PubMed  Google Scholar 

  • Miller FD, Mathew TC, Toma JG. 1991. Regulation of nerve growth factor receptor gene expression by nerve growth factor in the developing peripheral nervous system. J Cell Biol 112: 303–312.

    CAS  PubMed  Google Scholar 

  • Min DS, Ahn BH, Rhie DJ, Yoon SH, Hahn SJ, et al. 2001. Expression and regulation of phospholipase D during neuronal differentiation of PC12 cells. Neuropharmacology 41: 384–391.

    CAS  PubMed  Google Scholar 

  • Mizel SB, Bamburg JR. 1976. Studies on the action of nerve growth factor. III. Role of RNA and protein synthesis in the process of neurite outgrowth. Dev Biol 49: 20–28.

    CAS  PubMed  Google Scholar 

  • Mobley WC, Neve RL, Prusiner SB, McKinley MP. 1988. Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proc Natl Acad Sci USA 85: 9811–9815.

    CAS  PubMed  Google Scholar 

  • Mohiuddin L, Fernandez K, Tomlinson DR, Fernyhough P. 1995. Nerve growth factor and neurotrophin-3 enhance neurite outgrowth and up-regulate the levels of messenger RNA for growth-associated protein GAP-43 and T alpha 1 alpha-tubulin in cultured adult rat sensory neurones. Neurosci Lett 185: 20–23.

    CAS  PubMed  Google Scholar 

  • Mourey RJ, Vega QC, Campbell JS, Wenderoth MP, Hauschka SD, et al. 1996. A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation. J Biol Chem 271: 3795–3802.

    CAS  PubMed  Google Scholar 

  • Movsesyan V, Whalin M, Shibutani M, Katagiri Y, Broude E, et al. 1996. Down-regulation of cyclin F levels during nerve growth factor-induced differentiation of PC12 cells. Exp Cell Res 227: 203–207.

    CAS  PubMed  Google Scholar 

  • Mukouyama Y, Kuroyanagi H, Shirasawa T, Tomoda T, Saffen D, et al. 1997. Induction of protein tyrosine phosphatase epsilon transcripts during NGF-induced neuronal differentiation of PC12D cells and during the development of the cerebellum. Brain Res Mol Brain Res 50: 230–236.

    CAS  PubMed  Google Scholar 

  • Nakada N, Hongo S, Ohki T, Maeda A, Takeda M. 2002. Molecular characterization of NDRG4/Bdm1 protein isoforms that are differentially regulated during rat brain development. Brain Res Dev Brain Res 135: 45–53.

    CAS  PubMed  Google Scholar 

  • Naranjo-Suarez S, Castellanos MC, Alvarez-Tejado M, Vara A, Landazuri MO, et al. 2003. Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. J Biol Chem 278: 31895–31901.

    CAS  PubMed  Google Scholar 

  • Nur-E-Kamal, Qureshi MM, Ijaz MK, Galadari SH, Raza H. 2000. Proto-oncogene ras GTPase-linked induction of glutathione-S-transferase by growth factors in PC12 cells. Int J Oncol 16: 1043–1048.

    CAS  PubMed  Google Scholar 

  • Ohba H, Chiyoda T, Endo E, Yano M, Hayakawa Y, et al. 2004. Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1. Neurosci Lett 358: 157–160.

    CAS  PubMed  Google Scholar 

  • Oosawa H, Fujii T, Kawashima K. 1999. Nerve growth factor increases the synthesis and release of acetylcholine and the expression of vesicular acetylcholine transporter in primary cultured rat embryonic septal cells. J Neurosci Res 57: 381–387.

    CAS  PubMed  Google Scholar 

  • Osaka H, Sabban EL. 1997. Requirement for cAMP/calcium response element but not AP-1 site in fibroblast growth factor-2-elicited activation of tyrosine hydroxylase gene expression in PC12 cells. Brain Res Mol Brain Res 49: 222–228.

    CAS  PubMed  Google Scholar 

  • Paggi MG, Bonetto F, Severino A, Baldi A, Battista T, et al. 2001. The retinoblastoma-related Rb2/p130 gene is an effector downstream of AP-2 during neural differentiation. Oncogene 20: 2570–2578.

    CAS  PubMed  Google Scholar 

  • Partlow LM, Larrabee MG. 1971. Effects of a nerve-growth factor, embryo age and metabolic inhibitors on growth of fibres and on synthesis of ribonucleic acid and protein in embryonic sympathetic ganglia. J Neurochem 18: 2101–2118.

    CAS  PubMed  Google Scholar 

  • Peinado-Ramon P, Wallen A, Hallbook F. 1998. MAP kinase phosphatase-1 mRNA is expressed in embryonic sympathetic neurons and is upregulated after NGF stimulation. Brain Res Mol Brain Res 56: 256–267.

    CAS  PubMed  Google Scholar 

  • Persengiev SP, Kondova II, Kilpatrick DL. 1999. E2F4 actively promotes the initiation and maintenance of nerve growth factor-induced cell differentiation. Mol Cell Biol 19: 6048–6056.

    CAS  PubMed  Google Scholar 

  • Persengiev SP, Li J, Poulin ML, Kilpatrick DL. 2001. E2F2 converts reversibly differentiated PC12 cells to an irreversible, neurotrophin-dependent state. Oncogene 20: 5124–5131.

    CAS  PubMed  Google Scholar 

  • Pesheva P, Kuklinski S, Biersack HJ, Probstmeier R. 2000. Nerve growth factor-mediated expression of galectin-3 in mouse dorsal root ganglion neurons. Neurosci Lett 293: 37–40.

    CAS  PubMed  Google Scholar 

  • Planas B, Kolb PE, Raskind MA, Miller MA. 1997. Nerve growth factor induces galanin gene expression in the rat basal forebrain: Implications for the treatment of cholinergic dysfunction. J Comp Neurol 379: 563–570.

    CAS  PubMed  Google Scholar 

  • Prentice HM, Moore SE, Dickson JG, Doherty P, Walsh FS. 1987. Nerve growth factor-induced changes in neural cell adhesion molecule (N-CAM) in PC12 cells. Embo J 6: 1859–1863.

    CAS  PubMed  Google Scholar 

  • Probst JC, Landgraf R, Behl C. 1997. Expression of the trefoil polypeptide ITF in PC12 cells. Biochem Mol Biol Int 42: 425–432.

    CAS  PubMed  Google Scholar 

  • Rhodes J, Lutka FA, Jordan-Sciutto KL, Bowser R. 2003. Altered expression and distribution of FAC1 during NGF-induced neurite outgrowth of PC12 cells. Neuroreport 14: 449–452.

    CAS  PubMed  Google Scholar 

  • Rogers SW, Mandelzys A, Deneris ES, Cooper E, Heinemann S. 1992. The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF. J Neurosci 12: 4611–4623.

    CAS  PubMed  Google Scholar 

  • Romano C, Nichols RA, Greengard P, Greene LA. 1987. Synapsin I in PC12 cells. I. Characterization of the phosphoprotein and effect of chronic NGF treatment. J Neurosci 7: 1294–1299.

    CAS  PubMed  Google Scholar 

  • Rong P, Bennie AM, Epa WR, Barrett GL. 1999. Nerve growth factor determines survival and death of PC12 cells by regulation of the bcl-x, bax, and caspase-3 genes. J Neurochem 72: 2294–2300.

    CAS  PubMed  Google Scholar 

  • Sampath D, Jackson GR, Werrbach-Perez K, Perez-Polo JR. 1994. Effects of nerve growth factor on glutathione peroxidase and catalase in PC12 cells. J Neurochem 62: 2476–2479.

    CAS  PubMed  Google Scholar 

  • Sano K, Kikuchi A, Matsui Y, Teranishi Y, Takai Y. 1989. Tissue-specific expression of a novel GTP-binding protein (smg p25A) mRNA and its increase by nerve growth factor and cyclic AMP in rat pheochromocytoma PC-12 cells. Biochem Biophys Res Commun 158: 377–385.

    CAS  PubMed  Google Scholar 

  • Sharma E, Lombroso PJ. 1995. A neuronal protein tyrosine phosphatase induced by nerve growth factor. J Biol Chem 270: 49–53.

    CAS  PubMed  Google Scholar 

  • Sharma N, D'Arcangelo G, Kleinlaus A, Halegoua S, Trimmer JS. 1993. Nerve growth factor regulates the abundance and distribution of K+ channels in PC12 cells. J Cell Biol 123: 1835–1843.

    CAS  PubMed  Google Scholar 

  • Sheehy AM, Phung YT, Riemer RK, Black SM. 1997. Growth factor induction of nitric oxide synthase in rat pheochromocytoma cells. Brain Res Mol Brain Res 52: 71–77.

    CAS  PubMed  Google Scholar 

  • Shibutani M, Lazarovici P, Johnson AC, Katagiri Y, Guroff G. 1998. Transcriptional down-regulation of epidermal growth factor receptors by nerve growth factor treatment of PC12 cells. J Biol Chem 273: 6878–6884.

    CAS  PubMed  Google Scholar 

  • Shiozuka K, Watanabe Y, Ikeda T, Hashimoto S, Kawashima H. 1995. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase. Gene 162: 279–284.

    CAS  PubMed  Google Scholar 

  • Smith MA, Fanger GR, O'Connor LT, Bridle P, Maue RA. 1997. Selective regulation of agrin mRNA induction and alternative splicing in PC12 cells by Ras-dependent actions of nerve growth factor. J Biol Chem 272: 15675–15681.

    CAS  PubMed  Google Scholar 

  • Sobue K, Kanda K. 1989. Alpha-actinins, calspectin (brain spectrin or fodrin), and actin participate in adhesion and movement of growth cones. Neuron 3: 311–319.

    CAS  PubMed  Google Scholar 

  • Sohrabji F, Greene LA, Miranda RC, Toran-Allerand CD. 1994. Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells. J Neurobiol 25: 974–988.

    CAS  PubMed  Google Scholar 

  • Stefanis L, Kholodilov N, Rideout HJ, Burke RE, Greene LA. 2001. Synuclein-1 is selectively up-regulated in response to nerve growth factor treatment in PC12 cells. J Neurochem 76: 1165–1176.

    CAS  PubMed  Google Scholar 

  • Stein R, Orit S, Anderson DJ. 1988. The induction of a neural-specific gene, SCG10, by nerve growth factor in PC12 cells is transcriptional, protein synthesis dependent, and glucocorticoid inhibitable. Dev Biol 127: 316–325.

    CAS  PubMed  Google Scholar 

  • Takahashi T, Yamashita H, Nakamura S, Ishiguro H, Nagatsu T, et al. 1999. Effects of nerve growth factor and nicotine on the expression of nicotinic acetylcholine receptor subunits in PC12 cells. Neurosci Res 35: 175–181.

    CAS  PubMed  Google Scholar 

  • Takebayashi M, Hayashi T, Su TP. 2002. Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: Implications for antidepressants. J Pharmacol Exp Ther 303: 1227–1237.

    CAS  PubMed  Google Scholar 

  • Takekoshi K, Nomura F, Isobe K, Motooka M, Nammoku T, et al. 1998. Identification and initial characterization of stathmin by the differential display method in nerve growth factor-treated PC12 cells. Eur J Endocrinol 138: 707–712.

    CAS  PubMed  Google Scholar 

  • Tamaru T, Okada M, Nakagawa H. 1994. Differential expression of D type cyclins during neuronal maturation. Neurosci Lett 168: 229–232.

    CAS  PubMed  Google Scholar 

  • Taniguchi T, Morisawa K, Ogawa M, Yamamoto H, Fujimoto S. 1988. Decrease in the level of poly(ADP-ribose) synthetase during nerve growth factor-promoted neurite outgrowth in rat pheochromocytoma PC12 cells. Biochem Biophys Res Commun 154: 1034–1040.

    CAS  PubMed  Google Scholar 

  • Uittenbogaard M, Chiaramello A. 2002. Constitutive overexpression of the basic helix-loop-helix Nex1/MATH-2 transcription factor promotes neuronal differentiation of PC12 cells and neurite regeneration. J Neurosci Res 67: 235–245.

    CAS  PubMed  Google Scholar 

  • Vedder H, Affolter HU, Otten U. 1993. Nerve growth factor (NGF) regulates tachykinin gene expression and biosynthesis in rat sensory neurons during early postnatal development. Neuropeptides 24: 351–357.

    CAS  PubMed  Google Scholar 

  • Velculescu VE, Vogelstein B, Kinzler KW. 2000. Analysing uncharted transcriptomes with SAGE. Trends Genet 16: 423–425.

    CAS  PubMed  Google Scholar 

  • Vetter J, Betz H. 1989. Expression of synaptophysin in the rat pheochromocytoma cell line PC12. Exp Cell Res 184: 360–366.

    CAS  PubMed  Google Scholar 

  • Vician L, Basconcillo R, Herschman HR. 1997. Identification of genes preferentially induced by nerve growth factor versus epidermal growth factor in PC12 pheochromocytoma cells by means of representational difference analysis. J Neurosci Res 50: 32–43.

    CAS  PubMed  Google Scholar 

  • Vician L, Silver AL, Farias-Eisner R, Herschman HR. 2001. NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells. J Neurosci Res 64: 108–120.

    CAS  PubMed  Google Scholar 

  • Vignali G, Niclas J, Sprocati MT, Vale RD, Sirtori C, et al. 1996. Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells. Eur J Neurosci 8: 536–544.

    CAS  PubMed  Google Scholar 

  • Villa A, Latasa MJ, Pascual A. 2001. Nerve growth factor modulates the expression and secretion of beta-amyloid precursor protein through different mechanisms in PC12 cells. J Neurochem 77: 1077–1084.

    CAS  PubMed  Google Scholar 

  • Weinberger RP, Henke RC, Tolhurst O, Jeffrey PL, Gunning P. 1993. Induction of neuron-specific tropomyosin mRNAs by nerve growth factor is dependent on morphological differentiation. J Cell Biol 120: 205–215.

    CAS  PubMed  Google Scholar 

  • Winston J, Toma H, Shenoy M, Pasricha PJ. 2001. Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons. Pain 89: 181–186.

    CAS  PubMed  Google Scholar 

  • Wion D, Le Bert M, Brachet P. 1988. Messenger RNAs of beta-amyloid precursor protein and prion protein are regulated by nerve growth factor in PC12 cells. Int J Dev Neurosci 6: 387–393.

    CAS  PubMed  Google Scholar 

  • Woo CW, Lucarelli E, Thiele CJ. 2004. NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number. Oncogene 23: 1522–1530.

    CAS  PubMed  Google Scholar 

  • Wood JN, Lillycrop KA, Dent CL, Ninkina NN, Beech MM, et al. 1992. Regulation of expression of the neuronal POU protein Oct-2 by nerve growth factor. J Biol Chem 267: 17787–17791.

    CAS  PubMed  Google Scholar 

  • Yan GZ, Ziff EB. 1995. NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1. J Neurosci 15: 6200–6212.

    CAS  PubMed  Google Scholar 

  • Yan GZ, Ziff EB. 1997. Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor. J Neurosci 17: 6122–6132.

    CAS  PubMed  Google Scholar 

  • Zubiaur M, Neer EJ. 1993. Nerve growth factor changes G protein levels and localization in PC12 cells. J Neurosci Res 35: 207–217.

    CAS  PubMed  Google Scholar 

  • Zur KB, Oh Y, Waxman SG, Black JA. 1995. Differential up-regulation of sodium channel alpha- and beta 1-subunit mRNAs in cultured embryonic DRG neurons following exposure to NGF. Brain Res Mol Brain Res 30: 97–105.

    CAS  PubMed  Google Scholar 

Download references

Authors
  1. L. A. Greene
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. M. Angelastro
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 10962, 140 Old Orangeburg Road, Orangeburg, New York, USA

    Abel Lajtha (Director) (Director)

  2. Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, 301 University Blvd., TX, 77555, Galveston, USA

    J. Regino Perez-Polo (I. H. Kempner Professor and Chair Dept. Biochemistry & Molecular Biology Senior Scientist Sealy Center for Molecular Medicine Staff Scientist Shriner's Hospital for Children) (I. H. Kempner Professor and Chair Dept. Biochemistry & Molecular Biology Senior Scientist Sealy Center for Molecular Medicine Staff Scientist Shriner's Hospital for Children)

  3. Universität Leipzig Medizinische Fakultät, Paul-Flechsig-Institut für Hirnforschung, Jahnallee 59, 04109, Leipzig, Germany

    Steffen Rossner

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this entry

Cite this entry

Greene, L.A., Angelastro, J.M. (2008). Nerve Growth Factor Regulated Gene Expression. In: Lajtha, A., Perez-Polo, J.R., Rossner, S. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-32671-9_2

Download citation

Publish with us

Policies and ethics

Search

Navigation