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Role of Neurotrophins in the Formation and Maintenance of Synapses

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Molecular Mechanisms of Synaptogenesis

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1. Summary

During development, the establishment of precise synaptic connections between neurons and specific target cells is critical for normal function of the nervous system. Several attributes of neurotrophins, particularly their activitydependent expression and secretion, render these secreted proteins excellent extracellular signals that regulate the formation of synapses. Here we review experimental evidence for the potential role of neurotrophins in synapse formation. Members of the neurotrophin family have been shown to regulate the maturation of both excitatory and inhibitory synapses and also have been demonstrated to impact refinement of synaptic connections. Here, we discuss the multitude of signaling cascades that allow neurotrophins to achieve such diverse effects on CNS development and elaborate on the neurotrophin functions in the regulation of synaptogenesis in several important regions of the mammalian brain.

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Authors and Affiliations

  1. Section on Neural Development & Plasticity, NICHD, Bethesda, MD, 20892-3714

    Newton H. Woo, Hyun-soo Je & Bai Lu

  2. Genes, Cognition and Psychosis Program (GCAP), NIMH, National Institutes of Health, Bethesda, MD, 20892-3714

    Newton H. Woo, Hyun-soo Je & Bai Lu

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  1. Newton H. Woo
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  2. Hyun-soo Je
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Editors and Affiliations

  1. University Medical Center Hamburg-Eppendorf, 52 Martinistrasse, Hamburg, 20246, Germany

    Alexander Dityatev

  2. University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A1

    Alaa El-Husseini

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Woo, N.H., Je, Hs., Lu, B. (2006). Role of Neurotrophins in the Formation and Maintenance of Synapses. In: Dityatev, A., El-Husseini, A. (eds) Molecular Mechanisms of Synaptogenesis. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-32562-0_13

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