Skip to main content
SpringerLink
Log in

Metastatic Malignancy to the Lung

  • Chapter
Color Atlas of Pulmonary Cytopathology

  • 292 Accesses

Abstract

Extrapulmonary malignancies metastasize more frequently to the lungs than any other organ in the body. The reported incidence of lung metastases in autopsy studies on patients dying of extrapulmonary cancers range from 20 to 54%, whereas the lungs may be the only organs involved in 15-20% of the cases. Virtually any type of malignancy from any site or organ in the body can metastasize to the lungs; however, certain malignancies are more prone to involve the lungs. These are malignancies of breast, colon, kidney, uterine choriocarcinoma, stomach, pancreas, prostate, soft tissues, and male and female genital tracts. Patients with metastatic lung cancers may present clinically with signs and symptoms related to pulmonary involvement or may be asymptomatic.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

General

  • Askin FB. Something old? something new? Second primary or pulmonary metastasis in the patient with known extrathoracic carcinoma. Am J Clin Pathol 1993; 100: 4–5.

    PubMed  CAS  Google Scholar 

  • Bourke SJ, Henderson AF, Stevenson RD, et al. Endobronchial metastases simulating primary carcinoma of the lung. Respir Med 1989; 83: 151–152.

    Article  PubMed  CAS  Google Scholar 

  • Colby TV, Koss MN, Travis WD. Tumors of the Lower Respiratory Tract; Armed Forces Institute of Pathology fascicle, third series. Washigton, D.C.: AFIP, 1995. Dail DH, Hammar SP. Pulmonary Pathology, second edition. New York: Springer-Verlag, 1993.

    Google Scholar 

  • Filderman AE, Coopage 1, Shaw C, Mathay RA. Pulmonary and pleural manifestations of extrathoracic malignancies. Clin Chest Med 1989; 10: 747–807.

    PubMed  CAS  Google Scholar 

  • Johnston WW, Elson CE. Respiratory Tract. In: Bibbo M, editor. Comprehensive Cytopathology, second edition. Philadelphia: W.B. Saunders, 1996.Johnston WW. Percutaneous fine needle aspiration biopsy of the lung. A study of 1015 patients. Acta Cytol 1984; 28: 218–224.

    Google Scholar 

  • Kern WH, Schweizer C. Sputum cytology of metastatic carcinoma of the lung. Acta Cytol 1976; 20: 514–520.

    PubMed  CAS  Google Scholar 

  • Kini SR. Color Atlas of Differential Diagnosis in Exfoliative and Aspiration Cytopathology. Baltimore: Williams and Wilkins, 1999.Levy H, Horak DA, Lewis Ml. The value of bronchial washings and bronchoalveolar lavage in the diagnosis of lymphangitic carcinomatosis. Chest 1985; 87: 129–131.

    Google Scholar 

  • Masson RG, Ruggieri J. Pulmonary microvascular cytology. A new diagnostic application of pulmonary artery catheter. Chest 1985; 88: 908–914.

    Article  PubMed  CAS  Google Scholar 

  • Muller KM, Respondek M. Pulmonary metastases. Pathol Anat Lung 1990; 168 (Suppl.): 1137–1144.

    Google Scholar 

  • Patz EF, Fidler J, Knelson M, et al. Significance of percutaneous needle biopsy in patients with multiple pulmonary nodules and a single known primary malignancy. Chest 1995; 107: 601–604.

    Article  PubMed  Google Scholar 

  • Perez-Ordonez B, Bedard YC. Metastatic adamantinoma diagnosed by fine needle aspiration biopsy of the lung. Diagn Cytopathol 1994; 10: 347–351.

    Article  PubMed  CAS  Google Scholar 

  • Rabb SS, Berg LC, Swanson PE, et al. Adenocarcinoma in the lung in patients with breast cancer, a prospective analysis of the discriminatory value of immunohistology. Am J Clin Pathol 1993; 100: 27–35.

    Google Scholar 

  • Roviroses Casino A, Bellmunt J, Salud A, et al. Endobronchial metastases in colorectal adenocarcinoma. Tumor 1992; 78: 270273.

    Google Scholar 

  • Sahn SA. Malignancy metastatic to the pleura. Clin Chest Med 1998; 19: 351–361.

    Article  PubMed  CAS  Google Scholar 

  • Schriner RW, Ryn JH, Edwards WD. Microscopic pulmonary tumor embolism causing subacute cor pulmonale: a difficult antemortem diagnosis. Mayo Clin Proc 1991; 66: 143–148.

    PubMed  CAS  Google Scholar 

  • Stanley MW, Henry-Stanley M, Iber C. Bronchoalveolar Lavage: Cytology and Clinical Applications. New York: Igaku-Shoin, 1991.Suster S, Moran CA. Unusual manifestations of metastatic tumors to the lung. Semin Diagn Pathol 1995; 12: 193–206.

    Google Scholar 

  • Tao L-C. Lung, pleura and mediastinum. In: Kline TS, editor. Guides to Clinical Aspiration Biopsy. New York: Igaku-Shoin, 1988. Udelsman R, Roth JA, Lees D, et al. Endobronchial metastases from soft tissue tumors. J Surg Oncol 1986; 32: 145–147.

    Google Scholar 

  • Whitesell PL, Peters SG. Pulmonary manifestations of extrathoracic malignant lesions. Mayo Clin Proc 1993; 68: 485–491.

    Google Scholar 

Breast

  • Radio SJ, Rennard SI, Kessinger A, et al. Breast carcinoma in bronchoalveolar lavage: a cytologic and immunocytochemical study. Arch Pathol Lab Med 1989; 113: 333–336.

    PubMed  CAS  Google Scholar 

Thyroid

  • Chariot P, Feliz A, Honnel. Miliary opacities diagnosed as lung metastases of a thyroid carcinoma after 13 years of stability. Chest 1993; 104: 981–982.

    Article  PubMed  CAS  Google Scholar 

  • Hamilton CW, Bigner SH, Wells SA Jr., et al. Metastatic medullary thyroid carcinoma in sputum: Alight and electron microscopic study. Acta Cytol 1983; 27: 49–53.

    PubMed  CAS  Google Scholar 

  • Kini SR. Thyroid carcinoma metastatic to other body sites. In: Kline TS, editor. Thyroid, Guides to Clinical Aspiration Biopsy, second edition, chapter 14. New York: Igaku Shoin, 1996.

    Google Scholar 

  • Massin JP, Savoie JC, Gamier H, et al. Pulmonary metastasis in differentiated thyroid carcinoma. Cancer 1984; 53: 982–992.

    Article  PubMed  CAS  Google Scholar 

  • Samaan NA, Schultz PN, Hayne TP, et al. Pulmonary metastasis of differentiated thyroid carcinoma: treatment results in 101 patients. J Clin Endocrinol Metab 1985; 65: 376–380.

    Article  Google Scholar 

  • Weiland JE, de Lois Santos E, Mazzafari EL, et al. Hemoptysis as the presenting manifestation of thyroid carcinoma. Arch Intern Med 1989; 149: 1693–1694.

    Article  PubMed  CAS  Google Scholar 

  • Gastrointestinal Tract

    Google Scholar 

  • Flint A, Lloyd RV. Colon carcinoma metastatic the lung: cytologic manifestations and distinction from primary pulmonary adenocarcinoma. Acta Cytol 1992; 36: 230–235.

    PubMed  CAS  Google Scholar 

Adenoid Cystic Carcinoma

  • Anderson RJ, Johnston WW, Szpak CA. Fine needle aspiration of adenoid cystic carcinoma, metastatic to the lung. Cytologic features and differential diagnosis. Acta Cytol 1985; 29: 527–532.

    PubMed  CAS  Google Scholar 

  • Smith RC, Amy RW. Adenoid cystic carcinoma metastatic to the lung. Report of a case diagnosed by fine needle aspiration biopsy cytology. Acta Cytol 1985; 29: 535–536.

    Google Scholar 

  • Zimmerman RL, Bibbo M. Fine needle aspiration diagnosis of a pulmonary metastasis from a cutaneous adenoid cystic carcinoma. A case report. Acta Cytol 1998; 42: 367–370.

    Article  PubMed  CAS  Google Scholar 

Kidney

  • Nguyen G-K. Fine needle aspiration biopsy cytology of metastatic renal cell carcinoma. Acta Cytol 1988; 32: 409–414.

    PubMed  CAS  Google Scholar 

  • Saleh HA, Masood S, Wynn G, et al. Unsuspected metastatic renal cell carcinoma diagnosed by fine needle aspiration biopsy. A report of four cases with immunocytochemical contributions. Acta Cytol 1994; 38: 551–561.

    Google Scholar 

Transitional Cell Carcinoma

  • Johnson TL, Kini SR. Cytologic features of metastatic transitional cell carcinoma. Diagn Cytopathol 1993; 9: 270–278.

    Article  PubMed  CAS  Google Scholar 

  • Powers CN, Elbadawl A. “Cercariform” cells: a clue to the cytodiagnosis of transitional cell origin of metastatic neoplasms? Diagn Cytopathol 1995; 13: 15–21.

    Article  PubMed  CAS  Google Scholar 

Prostate

  • Bartziota EV. Fine needle aspiration cytology of prostatic adenocarcinoma metastatic to the lung confirmed by immunoperoxidase technique. Acta Cytol 1986; 30: 497–500.

    PubMed  CAS  Google Scholar 

  • Kenny JN, Smith WL, Brawer MK. Endobronchial metastases from prostate carcinoma. Ann Thorac Surg 1988; 45: 223–224.

    Article  PubMed  CAS  Google Scholar 

  • Veratraeten A, Saule MC, Wallaert B, et al. Metastatic prostatic adenocarcinoma diagnosed by bronchoalveolar lavage and tumor marker determination. Eur Respir J 1991; 4: 1296–1298.

    Google Scholar 

Ovary

  • Kerr VE, Cadman E. Pulmonary metastases in ovarian cancer. Cancer 1985; 56: 770–776.

    Article  Google Scholar 

  • Merrill CR, Hopkirk JAC. Late endobronchial metastases from ovarian tumor. Br J Dis Chest 1982; 76: 253–254.

    Article  PubMed  CAS  Google Scholar 

Gestational Trophoblastic Tumor

  • Hendin AS. Gestational trophoblastic tumors metastatic to the lungs. Cancer 1984; 53: 58–61.

    Article  PubMed  CAS  Google Scholar 

  • Kumar J, Hancheran A, Ratnam SS. Pulmonary metastases in gestational trophoblastic disease. A review of 97 cases. Br J Obstet Gynecol 1988; 95: 70–74.

    Article  CAS  Google Scholar 

Malignant Melanoma

  • Khaddami M. Cytologic diagnosis of metastatic malignant melanoma of the lung in sputum and bronchial washings. A case report. Acta Cytol 1993; 37: 403–408.

    Google Scholar 

  • Perry MD, Gore M, Seigler HF, et al. Fine needle aspiration biopsy of metastatic melanoma. A morphologic analysis of 174 cases. Acta Cytol 1986; 30: 385–396.

    PubMed  CAS  Google Scholar 

  • Poellein S, Rothenberg J, Penkova RR. Metastatic malignant melanoma in the lung diagnosed by thin-needle aspiration biopsy. Arch Pathol Lab Med 1982; 106: 119–120.

    PubMed  CAS  Google Scholar 

Choriocarcinoma

  • Craig ID, Slaum DT, Desrosiere P, et al. Choriocarcinoma metastatic to the lung. A cytologic study with identification of human choriogonadotropin with an immunoperoxidase technique. Acta Cytol 1983; 27: 647–650.

    PubMed  CAS  Google Scholar 

  • Hudson EA. Sputum cytology of metastatic choriocarcinoma. A case report. Acta Cytol 1981; 25: 29–32.

    PubMed  CAS  Google Scholar 

Soft Tissue Sarcomas

  • Ahmed MN, Feldman M, Seimayer TA. Cytology of epithelioid sarcoma (Letter). Acta Cytol 1984; 28: 459–461.

    Google Scholar 

  • Costa I, Lerma E, Esteve E, et al. Aspiration cytology of lung metastasis of monophasic synovial sarcoma. Report of a case. Acta Cytol 1997; 41: 1289–1292.

    Article  PubMed  CAS  Google Scholar 

  • Crosby JH, Hoeg K, Hager B. Transthoracic fine needle aspiration of primary and metastatic sarcomas. Diagn Cytopathol 1985; 1: 221–227.

    Article  PubMed  CAS  Google Scholar 

  • Kim K, Naylor B, Han IH. Fine needle aspiration cytology of sar- comas metastatic to the lung. Acta Cytol 1986; 30: 688–694.

    PubMed  CAS  Google Scholar 

  • Lozowski MS, Mishriki YY, Epstein H. Metastatic malignant fibrous histiocytoma in lung examined by fine needle aspiration: case report and literature review. Acta Cytol 1980; 24: 350–354.

    PubMed  CAS  Google Scholar 

  • Neiman TH, Bottles K. Cytologic diagnosis of metastatic epithelioid sarcoma: a cytologic mimic of squamous cell carcinoma. Am J Clin Pathol 1993; 100: 171–173.

    Google Scholar 

  • Saleh HA, Beydoun R, Masood S. Cytology of malignant Schwan-noma metastatic to the lung. Report of a case with diagnosis by fine needle aspiration biopsy. Acta Cytol 1993; 37: 409–412.

    PubMed  CAS  Google Scholar 

  • Saleh HA, Haapaniemi J. Aspiration biopsy cytopathology of malignant hemangiopericytoma metastatic to the lungs. Cytomorphologic and immunocytochemical study of a case. Acta Cytol 1997; 41: 1265–1268.

    CAS  Google Scholar 

  • Silverman JF, Weaver MD, Gardner N, et al. Aspiration biopsy cytology of malignant schwannoma metastatic to the lung. Acta Cytol 1985; 29: 15–18.

    PubMed  CAS  Google Scholar 

Bones

  • Dodd LG, Chai C, McAdams P, et al. Fine needle aspiration of osteogenic sarcoma metastatic to the lung. Report of four cases. Acta Cytol 1998; 42: 754–758.

    Article  PubMed  CAS  Google Scholar 

  • Szyfelbein WM, Schiller AL. Cytologic diagnosis of giant cell tu- mor of bone metastatic to lung. Acta Cytol 1979; 23: 460–464.

    PubMed  CAS  Google Scholar 

  • Tabei SZ, Abdollahi B, Nilli F. Diagnosis of metastatic adamantin-orna of the tibia by pulmonary brushing cytology. Acta Cytol 1988; 32: 579–581.

    PubMed  CAS  Google Scholar 

Meningioma

  • Stollar JK, Kavuru M, Mehta AC, et al. Intracranial meningioma metastatic to the lung. Clev Clin J Med 1987; 54: 521–527.

    Google Scholar 

  • Tao LC. Pulmonary metastasis from intracranial meningioma diagnosed by aspiration biopsy cytology. Acta Cytol 1991; 35: 524–528.

    PubMed  CAS  Google Scholar 

  • Tworek JA, Mikhail AA, Blaivs M. Meningioma: local recurrence and pulmonary metastasis diagnosed by fine needle aspiration (Letter). Acta Cytol 1997; 41: 946–947.

    PubMed  CAS  Google Scholar 

Miscellaneous

  • Spahr J, Frable WJ. Pulmonary cytopathology of an invasive thymoma. Acta Cytol 1981; 25: 63–166.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division Head Cytopathology, Department of Pathology, Henry Ford Hospital, 48202, Detroit, Michigan, USA

    Sudha R. Kini MD

Authors
  1. Sudha R. Kini MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Kini, S.R. (2002). Metastatic Malignancy to the Lung. In: Color Atlas of Pulmonary Cytopathology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-21641-6_13

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-21641-6_13

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-2977-8

  • Online ISBN: 978-0-387-21641-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation