Abstract
Recent years have seen a significant increase in the reports of atypical antipsychotic diversion, misuse and even dependency syndrome. These reports have arisen amidst a marked increase in prescribing of these agents. Much of this increase in prescribing is because of a preferential use of these medications over typical antipsychotic agents to treat schizophrenia and bipolar disorder due to perceptions of fewer extrapyramidal side effects. However, there has also been a significant increase in the off-label prescribing of these medicines to treat less well evidence-based conditions. Misuse and abuse are perhaps surprising given the putative central role of dopamine in addiction and that these agents are dopamine antagonists. However, there may be other factors such as other pharmacological effects and increasing availability driving this misuse. It is also apparent that certain patient groups appear to be more at risk. Here, we explore the evidence behind the misuse of atypical antipsychotics with a focus of quetiapine. We consider the factors that may be driving this misuse, and then, we also detail some of the adverse effects that may ensue. We end by suggesting interventions at a prescriber and systems level that may be implemented to reduce the risk of atypical antipsychotic misuse.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Australia Co (2013) National pharmaceutical drug misuse framework for action (2012–2015)
Balit CR, Isbister GK, Hackett LP, Whyte IM (2003) Quetiapine poisoning: a case series. Ann Emerg Med 42:751–758
Bogart GT, Ott CA (2011) Abuse of second-generation antipsychotics: what prescribers need to know. Curr Psychiatry 10:77–79
Buckley N, Whyte IM, Dawson AH, Isbister GK (2015) 26 Years of self-poisoning in Newcastle, 1987–2012. Aust Med J 202(8):438–442
Crime UNOoDa (2011) The non-medical use of prescription drugs. In: Policy direction issues discussion paper. United Nations Office on Drugs and Crime, New York
Cubala WJ, Springer J (2014) Quetiapine abuse and dependence in psychiatric patients: a treatment. J Subst Use 19:388–393
Health AGDo (2015) Schedule of pharmaceutical benefits. Australian Capital Territory: Commonwealth of Australia
Heilbronn CE, Lloyd B, McElwee P, Eade A, Lubman DI (2013) Trends in quetapine use and non-fatal quetiapine-related ambulance attendances. Drug Alcohol Rev 32:405–411
Hollingworth SA, Siskind DJ, Nissen LM, Robinson M, Hall WD (2010) Patterns of antipsychotic medication use in Australia 2002–2007. Aust NZJ Psychiatry 44:372–377
Huthwaite M, Cleghorn M, MacDonald J (2014) ‘Out of the frying pan’: the challenges of prescribing for insomnia in psychiatric patients. Australas Psychiatry 22:288–291
Isbister GK, Duffull SB (2009) Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal. Int Clin Psychopharmacol 24:174–180
Kessler RC, Chiu WT, Demler O, Walters EE (2005) Prevalence, severity and comorbidity of 12-Month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62:617–627
Klein-Schwartz W, Schwartz EK, Anderson BD (2014) Evaluation of quetiapine abuse and misuse reported to poison centers. J Addict Med 8:195–198
Kumsar NA, Erol A (2013) Olanzapine abuse. Subst Abuse 34:73–74
Kuroki T, Nagao N, Nakahara T (2008) Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesis. Prog Brain Res 172:199–212
Lai CH (2010) Olanzapine abuse was relieved after switching to aripiprazole in a patient with psychotic depression. Prog Neuropsychopharmacol Biol Psychiatry 34:1363–1364
Malekshahi T, Tioleco N, Ahmed N, Campbell ANC, Haller D (2015) Misuse of atypical antipsychotics in conjunction with alcohol and other drugs of abuse. J Subst Abuse Treat 48:8–12
McKean A, Monasterio E (2012) Off-label use of atypical antipsychotics: cause for concern? CNS Drugs 26:383–390
McLarnon ME, Fulton HG, MacIsaac C, Barrett SP (2012) Characteristics of quetiapine misuse among clients of a community-based methadone maintenance program. J Clin Psychopharmacol 32:721–723
Milligan L (2013) Concerns grow over top-selling drug’s side effects. In: Corporation AB (ed) 730 Report: ABC
Moncrieff J, Cohen D, Porter S (2013) The psychoactive effects of psychiatric medication: the elephant in the room. J Psychoactive Drugs 45:409–415
Nielsen M, Hansen EH, Gøtzsche PC (2012) What is the difference between dependence and withdrawal reactions? A comparison of benzodiazepines and selective serotonin re-uptake inhibitors. Addiction 107:900–908
Passik SD, Portenoy RK, Ricketts PL (1998a) Substance abuse issues in cancer patients. Part 1: prevalence and diagnosis. Oncology 12:517–521
Passik SD, Portenoy RK, Ricketts PL (1998b) Substance abuse issues in cancer patients. Part 2: evaluation and treatment. Oncology 12:729–734
PBS Schedule search for “QUETIAPINE” (2015) Commonwealth of Australia. Accessed 12/02/2015, at http://www.pbs.gov.au/pbs/search?term=QUETIAPINE
Pilgrim JL, Drummer OH (2013) The toxicity and comorbidities of fatal cases involving quetiapine. Forensic Sci Med Pathol 9:170–176
Reddel SE, Bruno R, Burns L, Kirwan A, Lukuge K, Dietze P (2014) Prevalence and associations of quetiapine fumarate misuse among an Australian national city sample of people who regularly inject drugs. Addiction 109:295–302
Reeves RR (2007) Abuse of Olanzapine by substance users. J Psychoactive Drugs 39:297–299
Reeves R (2012) Guideline, education and peer comparison to reduce prescriptions of benzodiazepines and low-dose quetiapine in prison. J Corrective Health Care 18:45–52
Sansone RA, Sansone LA (2010) Is seroquel developing an illicit reputation for misuse/abuse? Psychiatry 7:13–16
Scott IA, Elshaug AG (2013) Foregoing low-value care: how much evidence is needed to change beliefs? Intern Med J 43:107–109
Seroquel (quetiapine fumarate) Tablets (2013) AstraZeneca Pharamceuticals LP. Accessed 14/05/2015, at http://www1.astrazeneca-us.com/pi/seroquel.pdf
Seroquel XR quetiapine fumarate Product Information. AstraZeneca, 2014. Accessed 14/05/2015, at http://www.medicines.org.au/files/appserxr.pdf
Service NP (2014) Low-dose quetiapine: place in therapy? Health News and Evidence: NPS Medicinewise
Simonsen KW, Edvardsen HME et al (2015) Fatal poisoning in drug addicts in the Nordic countries in 2012. Forensic Sci Int 248:172–180
Smith JM (1980) Abuse of the antiparkinson drugs: a review of the literature. J Clin Psychiatry 41:351–354
Srivastava A, Patil V, Da Silva Pereira Y (2013) A case series of quetiapine addiction/dependence. Ger J Psychiatry 16:152–155
Stafford J, Burns L (2014) Australian Drug Trends 2013. In: Findings from the illicit drug reporting system (IDRS). University of New South Wales, Australia
Stephenson CP, Karanges E, McGregor IS (2012) Trends in the utilisation of psychotropic medications in Australia from 2000 to 2011. Aust NZJ Psychiatry 47:74–87
Tcheremissine OV (2008) Is quetiapine a drug of abuse? Re-examining the issueof addiction. Expert Opin Drug Safety 7:739–748
Welfare AIoHa (2013) National drug strategy household survey detailed report. Canberra
WHO (2015) Management of substance abuse. Accessed 28/05/2015, at http://www.who.int/substance_abuse/terminology/definition1/en/
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Montebello, M.E., Brett, J. (2015). Misuse and Associated Harms of Quetiapine and Other Atypical Antipsychotics. In: Nielsen, S., Bruno, R., Schenk, S. (eds) Non-medical and illicit use of psychoactive drugs. Current Topics in Behavioral Neurosciences, vol 34. Springer, Cham. https://doi.org/10.1007/7854_2015_424
Download citation
DOI: https://doi.org/10.1007/7854_2015_424
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-60014-7
Online ISBN: 978-3-319-60016-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)