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Rab GTPases in Plant Endocytosis

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Plant Endocytosis

Part of the book series: Plant Cell Monographs ((CELLMONO,volume 1))

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Abstract

The Rab family is part of the Ras superfamily of small GTPases. In eukaryotes Rab GTPases are present as members of gene families, and the different Rab GTPase isoforms are localized specific intracellular membranes, where they function as regulators of distinct steps in membrane traffic pathways. They perform these regulatory functions through the specific recruitment of cytosolic effector proteins onto membranes. This recruitment occurs when the Rab GTPase is in the GTP-bound, or active, form. Through these recruited effector proteins, Rab GTPases regulate many aspects of membrane trafficking including vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. The recent sequencing of complete genomic sequences from animal, yeast, and plant organisms has revealed that a number of Rab GTPase families are conserved from yeast to animals and plants. The plant model system, Arabidopsis thaliana, contains 57 Rab GTPases, of which 40 distinct Rab GTPase members of four subfamilies RabA (26 members), RabC (three members), RabF (three members), and RabG (eight members) share significant similarity with Rab GTPases implicated in endocytic events in animals and yeast. In this review we will highlight recent observations of the function of some of these plant Rab GTPases during endocytosis in plants, and discuss possible roles of plant endocytic Rab GTPases in relation to what is currently known in animal and yeast systems.

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  1. Donald Danforth Plant Science Center, Missouri 63132, St. Louis, USA

    Erik Nielsen

  2. Department of Biology, Washington University in St. Louis, One Brookings Dr., MO 63130, St. Louis, USA

    Erik Nielsen

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Jozef Šamaj František Baluška Diedrik Menzel

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Nielsen, E. Rab GTPases in Plant Endocytosis. In: Šamaj, J., Baluška, F., Menzel, D. (eds) Plant Endocytosis. Plant Cell Monographs, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7089_011

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