Skip to main content
SpringerLink
Log in

Phenylalanine dehydrogenase

  • Chapter
Springer Handbook of Enzymes

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 22))

  • 589 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Okazaki, N.; Hibino, Y.; Asano, Y.; Ohmori, M.; Numao, N.; Kondo, K.: Cloning and nucleotide sequencing of phenylalanine dehydrogenase gene of Bacillus sphaericus. Gene, 63, 337–341 (1988)

    Article  PubMed  CAS  Google Scholar 

  2. Asano, Y.; Nakazawa, A.: Crystallization of phenylalanine dehydrogenase from Sporosarcina urea. Agric. Biol. Chem., 49, 3631–3632 (1985)

    CAS  Google Scholar 

  3. Asano, Y.; Nakazawa, A.; Endo, K.: Novel phenylalanine dehydrogenases from Sporosarcina ureae and Bacillus sphaericus. Purification and characterization. J. Biol. Chem., 262, 10346–10354 (1987)

    PubMed  CAS  Google Scholar 

  4. De Boer, L.; Van Rijssel, M.; Euverink, G.J.; Dijkhuizen, L.: Purification, characterization and regulation of a monomeric l-phenylalanine dehydrogenase from the facultative methylotroph Nocardia sp. 239. Arch. Microbiol., 153, 12–18 (1989)

    Article  Google Scholar 

  5. Misono, H.; Yonezawa, J.; Nagata, S.; Nagasaki, S.: Purification and characterization of a dimeric phenylalanine dehydrogenase from Rhodococcus maris K-18. J. Bacteriol., 171, 30–36 (1989)

    PubMed  CAS  Google Scholar 

  6. Asano, Y.; Endo, K.; Nakazawa, A.; Hibino, Y.; Okazaki, N.; Ohmori, M.; Numao, N.; Kondo, K.: Bacillus phenylalanine dehydrogenase produced in Escherichia coli — Its purification and application to l-phenylalanine synthesis. Agric. Biol. Chem., 51, 2621–2623 (1987)

    CAS  Google Scholar 

  7. Asano, Y.; Nakazawa, A.; Endo, K.; Hibino, Y.; Ohmori, M.; Numao, N.; Kondo, K.: Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning [published erratum appears in Eur. J. Biochem. 1988 Jan l;170(3):667]. Eur. J. Biochem., 168, 153–159 (1987)

    Article  PubMed  CAS  Google Scholar 

  8. Hummel, W.; Weiss, N.; Kula, M.R.: Isolation and characterization of a bacterium possessing l-phenylalanine dehydrogenase activity. Arch. Microbiol., 137, 47–52 (1984)

    Article  CAS  Google Scholar 

  9. Hummel, W.; Schuette, H.; Schmidt, E.; Wandrey C.; Kula, M.R.: Isolation of l-phenylalanine dehydrogenase from Rhodococcus sp. M4 and its application for the production of l-phenylalanine. Appl. Microbiol. Biotechnol., 26, 409–416 (1987)

    Article  CAS  Google Scholar 

  10. Hummel, W.; Schuette, H.; Kula, M.R.: Enzymatic determination of l-phenylalanine and phenylpyruvate with l-phenylalanine dehydrogenase. Anal. Biochem., 170, 397–401 (1988)

    Article  PubMed  CAS  Google Scholar 

  11. Campagna, R.; Bueckmann, A.F.: Comparison of the production of intracellular l-phenylalanine dehydrogenase by Rhodococcus species M4 and Sporosarcina urea at 50 liter scale. Appl. Microbiol. Biotechnol., 26, 417–421 (1987)

    Article  CAS  Google Scholar 

  12. Wendel, U.; Hummel, W.; Langenbeck, U.: Monitoring of phenylketonuria: a colorimetric method for the determination of plasma phenylalanine using l-phenylalanine dehydrogenase. Anal. Biochem., 180, 91–94 (1989)

    Article  PubMed  CAS  Google Scholar 

  13. Hummel, W.; Schuette, H.; Schmidt, E.; Kula, M.R.: Neue Moeglichkeiten zur enzymatischen Herstellung von l-Phenylalanin. GBF Monogr. Ser. Volume date 1988, 11, 207–210 (1989)

    Google Scholar 

  14. Cooper, A.J.L.; Leung, L.K.H.; Asano, Y.: Enzymatic cycling assay for phenylpyruvate. Anal. Biochem., 183, 210–214 (1989)

    Article  PubMed  CAS  Google Scholar 

  15. Asano, Y.; Nakazawa, A.: High yield synthesis of l-amino acids by phenylalanine dehydrogenase from Sporosarcina urea. Agric. Biol. Chem., 51, 2035–2036 (1987)

    CAS  Google Scholar 

  16. Kataoka, K.; Takada, H.; Tanizawa, K.; Yoshimura, T.; Esaki, N.; Ohshima, T.; Soda, K.: Construction and characterization of chimeric enzyme consisting of an amino-terminal domain of phenylalanine dehydrogenase and a carboxy-terminal domain of leucine dehydrogenase. J. Biochem., 116, 931–936 (1994)

    PubMed  CAS  Google Scholar 

  17. Kataoka, K.; Tanizawa, K.; Fukui, T.; Ueno, H.; Yoshimura, T.; Esaki, N.; Soda, K.: Identification of active site lysyl residues of phenylalanine dehydrogenase by chemical modification with methyl acetyl phosphate combined with site-directed mutagenesis. J. Biochem., 116, 1370–1376 (1994)

    PubMed  CAS  Google Scholar 

  18. Kataoka, K.; Takada, H.; Yoshimura, T.; Furuyoshi, S.; Esaki, N.; Ohshima, T.; Soda, K.: Site-directed mutagenesis of a hexapeptide segment involved in substrate recognition of phenylalanine dehydrogenase from Thermoactinomyces intermedius. J. Biochem., 114, 69–75 (1993)

    PubMed  CAS  Google Scholar 

  19. Asano, Y; Tanetani, M.: Thermostable phenylalanine dehydrogenase from a mesophilic Microbacterium sp. strain DM 86-1. Arch. Microbiol., 169, 220–224 (1998)

    Article  PubMed  CAS  Google Scholar 

  20. Brunhuber, N.M.W.; Thoden, J.B.; Blanchard, J.S.; Vanhooke, J.L.: Rhodococcus l-phenylalanine dehydrogenase: kinetics, mechanism, and structural basis for catalytic specifity. Biochemistry, 39, 9174–9187 (2000)

    Article  PubMed  CAS  Google Scholar 

  21. Vanhooke, J.L.; Thoden, J.B.; Brunhuber, N.M.W.; Blanchard, J.S.; Holden, H.M.: Phenylalanine dehydrogenase from Rhodococcus sp. M4: High-resolution x-ray analyses of inhibitory ternary complexes reveal key features in the oxidative deamination mechanism. Biochemistry, 38, 2326–2339 (1999)

    Article  PubMed  CAS  Google Scholar 

  22. Hanson, R.L.; Howell, J.M.; LaPorte, T.L.; Donovan, M.J.; Cazzulino, D.L.; Zannella, V.; Montana, M.A.; Nanduri, V.B.; Schwarz, S.R.; Eiring, R.F.; Durand, S.C.; Wasylyk, J.M.; Parker, W.L.; Liu, M.S.; Okuniewicz, F.J.; Chen, B.C.; Harris, J.C.; Natalie,: Synthesis of allysine ethylene acetal using phenylalanine dehydrogenase from Thermoactinomyces intermedius. Enzyme Microb. Technol., 26, 348–358 (2000)

    Article  PubMed  CAS  Google Scholar 

  23. Seah, S.Y.; Britton, K.L.; Baker, P.J.; Rice, D.W.; Asano, Y.; Engel, P.C.: Alteration in relative activities of phenylalanine dehydrogenase towards different Substrates by site-directed mutagenesis. FEBS Lett., 370, 93–96. (1995)

    Article  PubMed  CAS  Google Scholar 

  24. Pasquo, A.; Britton, K.L.; Baker, P.J.; Brearley, G.; Hinton, R.J.; Moir, A.J.G.; Stillman, T.J.; Rice, D.W.: Crystallization of NAD+-dependent phenylalanine dehydrogenase from Nocardia sp239. Acta Crystallogr. Sect. D, 54, 269–272 (1998)

    Article  CAS  Google Scholar 

Download references

Editor information

Editors and Affiliations

  1. Institute for Biochemistry, University to Cologne, Zülpicher Strasse 47, 50674, Cologne, Germany

    Dietmar Schomburg  & Ida Schomburg  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2005). Phenylalanine dehydrogenase. In: Schomburg, D., Schomburg, I. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37646-1_20

Download citation

Publish with us

Policies and ethics

Search

Navigation