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Imitation Switch Complexes

  • Conference paper
The Histone Code and Beyond

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 57))

Abstract

The imitation switch (ISWI) family of chromatin remodelling ATPases is found in organisms ranging from yeast to mammals. ISWI ATPases assemble chromatin and slide and space nucleosomes, making the chromatin template fluid and allowing appropriate regulation of events such as transcription, DNA replication, recombination and repair. The site of action of the ATPases is determined, in part by the tissue type in which the enzyme is expressed and in part by the nature of the proteins associated with the enzyme. The ISWI complexes are generally conserved in composition and function across species. Roles in gene expression and DNA replication in heterochromatin, gene activation and repression in euchromatin, and functions related to maintaining chromosome architecture are associated with different complexes. Defects in ISWI-associated proteins may be associated with neurodegenerative disease, anencephaly, William’s syndrome and melanotic tumours. Finally, the mechanism by which yeast Isw1b influences gene transcription is discussed.

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Authors and Affiliations

  1. Department of Biochemistry, Oxford, South Parks Road, OX1 3 QU, Oxford, UK

    J. Mellor

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  1. J. Mellor
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Editors and Affiliations

  1. Gene Expression and Regulation Program, The Wistar Institute, 3601 Spruce Street, Room 201, PA, 19104, Philadelphia, USA

    S. L. Berger

  2. CRBA Oncology, Nihon Schering, Kobe, Japan

    O. Nakanishi

  3. CRBA Oncology, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    B. Haendler

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© 2006 Springer-Verlag Berlin Heidelberg

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Mellor, J. (2006). Imitation Switch Complexes. In: Berger, S.L., Nakanishi, O., Haendler, B. (eds) The Histone Code and Beyond. Ernst Schering Research Foundation Workshop, vol 57. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37633-X_4

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  • DOI: https://doi.org/10.1007/3-540-37633-X_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-27857-3

  • Online ISBN: 978-3-540-37633-0

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