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Interplay of the SUMO and MAP Kinase Pathways

  • Conference paper
The Histone Code and Beyond

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 57))

Abstract

The SUMO modification pathway has been linked with controlling the activity of numerous transcriptional regulatory proteins. In the majority of substrates studied so far, sumoylation imparts repressive properties. In several cases, part of this mechanism has been shown to be due to SUMO-dependent recruitment of histone deacetylases (HDACs). This is exemplified by the transcription factor Elk-1, where HDAC-2 is specifically recruited in response to sumoylation. Importantly, activation of the ERK MAP kinase pathway leads to Elk-1 desumoylation and HDAC loss. Furthermore, PIAS proteins can regulate the activities of transcription factors in SUMO-dependent and -independent manners. Further links between the MAP kinase pathways and PIAS proteins have been uncovered, suggesting a complex interplay been the MAP kinase and SUMO modification pathways. Here we discuss the current evidence suggesting links between the SUMO and MAP kinase pathways and point to other potential regulatory events and how these might be affected in cancer.

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Author information

Authors and Affiliations

  1. Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK

    S. -H. Yang

  2. Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Room A2028, M13 9PT, Manchester, GB

    A. D. Sharrocks

Authors
  1. S. -H. Yang
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  2. A. D. Sharrocks
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Editor information

Editors and Affiliations

  1. Gene Expression and Regulation Program, The Wistar Institute, 3601 Spruce Street, Room 201, PA, 19104, Philadelphia, USA

    S. L. Berger

  2. CRBA Oncology, Nihon Schering, Kobe, Japan

    O. Nakanishi

  3. CRBA Oncology, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    B. Haendler

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© 2006 Springer-Verlag Berlin Heidelberg

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Yang, S.H., Sharrocks, A.D. (2006). Interplay of the SUMO and MAP Kinase Pathways. In: Berger, S.L., Nakanishi, O., Haendler, B. (eds) The Histone Code and Beyond. Ernst Schering Research Foundation Workshop, vol 57. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37633-X_11

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  • DOI: https://doi.org/10.1007/3-540-37633-X_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-27857-3

  • Online ISBN: 978-3-540-37633-0

  • eBook Packages: MedicineMedicine (R0)

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