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References
Moore RM, Jeng LL, Kaczmarek RG, Placek PJ (1990) Use of diagnostic imaging procedures and fetal monitoring devices in the care of pregnant women. Public Health Rep 105:471–475
Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Munson ML (2003) Births: Final Data for 2002; National Vital Statistics Reports, Vol. 52,No. 10
Duck FA, Henderson J (1998) Acoustic output of modern ultrasound equipment: Is it increasing? In: Barnett SB, Kossoff G (eds) Safety of diagnostic ultrasound. Parthenon Publishing Group, New York, pp 15–25
Henderson J, Willson K, Jago JR, Whittingham TA (1995) A survey of the acoustic outputs of diagnostic ultrasound equipment in current clinical use. Ultrasound Med Biol 21: 699–705
O’Brien WD Jr, Abbott JG, Stratmeyer ME, Harris GR, Schafer ME, Siddigi TA, Merritt CR, Duck FA, Bendick PJ (2002) Acoustic output upper limits proposition: should upper limits be retained? J Ultrasound Med 21:1327–1333
Exposure Criteria for Medical Diagnostic Ultrasound; II. Criteria Based on All Known Mechanisms (2002) NCRP Report 140
American Institute of Ultrasound in Medicine (1997) Official Statement. Conclusions Regarding Heat
Barnett SB, Maulik D (2001) Guidelines and recommendations for safe use of Doppler ultrasound in perinatal applications. J Maternal Fetal Med 10:75–84
European Federation of Societies for Ultrasound in Medicine and Biology (2003) EFSUMB Clinical Safety Statement. EFSUMB Newsletter 17:15
World Federation for Ultrasound in Medicine and Biology (1998) WFUMB Symposium on safety of ultrasound in medicine: Conclusions and recommendations on thermal and non thermal mechanisms for biological effects of ultrasound. Ultrasound Med Biol 8:733–737
Bioeffects Committee of the American Institute of Ultrasound in Medicine (1991) Safety considerations for diagnostic ultrasound. AIUM Publications, Rockville, MD
American Institute of Ultrasound in Medicine (1992) The standard for real-time display of thermal and mechanical acoustic output indices on diagnostic ultrasound equipment. AIUM/NEMA, Laurel, MD
FDA (1993) Revised 510(k) diagnostic ultrasound guidance for 1993. Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, MD
American Institute of Ultrasound in Medicine/National Electrical Manufacturers Association (1998) Standard for real-time display of thermal and mechanical acoustic output indices on diagnostic ultrasound equipment, Revision 1. AIUM Publications, Laurel, MD
Nyborg WL (1981) Heat generation in a relaxing medium. J Acoust Soc Am 70:310–312
Duck FA (1990) Physical properties of tissue: a comprehensive reference book. Academic Press, London
National Council on Radiation Protection and Measurements (1992) Exposure criteria for medical diagnostic ultrasound: 1. Criteria based on thermal mechanisms. NCRP, Bethesda, MD, Report no. 113
Villar J (2000) Heat shock protein gene expression and survival in critical illness. Crit Care 4:2–5
Dewey WC (1994) Arrhenius relationships from the molecule and cell to the clinic. Int J Hyperthermia 10:457–483
Duck FA (2003) Working towards the boundaries of safety. EFSUMB Newsletter 16:8–11
Shaw A, Pay NM, Preston RC (1998) Assessment of the likely thermal index values for pulsed Doppler ultrasonic equipment Stages 2 & 3: Experimental assessment of scanner/transducer combinations. NPL Report CMAM 12 National Physical Laboratory, London
Lele PP (1979) Review: safety and potential hazards of in the current applications of ultrasound in obstetrics and gynecology. Ultrasound Med Biol 5:307–320
Miller MW, Ziskin MC (1989) Biological consequences of hyperthermia. Ultrasound Med Biol 15:707–722
Tarantal AF, Chu F, O’Brien WD Jr, Hendrick AG (1993) Sonographic heat generation in vivo in the gravid long-tailed macaque (Macaca fascicularis). J Ultrasound Med 12:285–295
Drewniak JL, Carnes KI, Dunn F (1989) In vitro ultrasonic heating of fetal bone. J Acoust Soc Am 86:1254–1258
Bosward KL, Barnett SB, Wood AK, Edwards MJ, Kossoff G (1993) Heating of guinea-pig fetal brain during exposure to pulsed ultrasound. Ultrasound Med Biol 19:415–424
Barnett SB (2001) Intracranial temperature elevation from diagnostic ultrasound. Ultrasound Med Biol 27:883–888
Stone PR, Ross I, Pringle K, Flower J (1992) Tissue heating effect of pulsed Doppler ultrasound in the live fetal lamb brain. J Fetal Diagn Ther 7:26–30
Mariak Z, Krejza J, Swiercz M, Lyson T, Lewko J (2001) Human brain temperature in vivo: lack of heating during color transcranial Doppler ultrasonography. J Neuroimaging 11:308–312
Morishima HO, Yeh M, Niemann WH, James LS (1977) Temperature gradient between mother and fetus as an index for assessing intrauterine fetal condition. Am J Obstet Gynecol 129:443–448
Beard RW, Wood C (1964) Temperature of the human foetus. J Obstet Gynaecol Br Commonw 71:768–769
Macaulay JH, Randall NR, Bond K, Steer PJ (1992) Continuous monitoring of fetal temperature by noninvasive probe and its relationship to maternal temperature, fetal heart rate, and cord arterial oxygen and pH. Obstet Gynecol 79:469–474
Macaulay JH, Bond K, Steer PJ (1992) Epidural analgesia in labor and fetal hyperthermia. Obstet Gynecol 80:665–669
Flynn HG (1964) Physics of acoustic cavitation in liquids. In: Mason WP (ed) Physical acoustics. Section 1B. Academic Press, Orlando, FL, p 57
Coakley WT, Nyborg WL (1978) Dynamics of gas bubbles, applications. In: Fry FJ (ed) Ultrasound: its applications in medicine and biology, Part 1. Elsevier, Amsterdam, p 77
Nyborg WL (1979) Physical mechanisms for biological effects of ultrasound. In: Repachililo MH, Benwell DA (eds) Ultrasound short course transactions. Radiation Protection Bureau, Health Protection Branch, Health and Welfare, Canada, p 83
Carstensen EL, Duck FA, Meltzer RS, Schwarz KQ, Keller B (1992) Bioeffects in echocardiography. Echocardiography 6:605–623
Suslick KS (1990) Sonochemistry. Science 247:1439–1445
Nyborg WL (1978) Physical principles of ultrasound. In: Fry FJ (ed) Methods and phenomena 3, ultrasound: its applications in medicine and biology, part 1. Elsevier, Amsterdam, p 1
Miller DL, Nyborg WL, Whitcomb DC (1979) Platelet aggregation induced by ultrasound under specialized conditions in vitro. Science 205:505–507
Hill CR, Joshi GP (1970) The significance of cavitation in interpreting the biological effects of ultrasound. In: Proceedings of Conference on Ultrasonics in Biology and Medicine. Warsaw, UBIOMED-70, p 125
Carstensen EL, Flynn HG (1983) The potential of transient cavitation with microsecond pulses of ultrasound. Ultrasound Med Biol 9:L451–L455
Delius M, Enders G, Heine G et al (1987) Biological effects of shock waves: Lung hemorrhage by shock waves in dogs — pressure dependence. Ultrasound Med Biol 13:61–67
Frizzell LA, Lee CS, Aschenbach PD et al (1983) Involvement of ultrasonically induced cavitation in the production of hind limb paralysis of the mouse neonate. J Acoustic Soc Am 74:1062–1065
Lee CS, Frizzell LA (1988) Exposure levels for ultrasonic cavitation in the mouse neonate. Ultrasound Med Biol 14:735–742
Church CC, Miller MW (1983) On the kinetics and mechanics of ultrasonically induced cell lysis by non trapped bubbles in a rotating culture tube. Ultrasound Med Biol 9:385–393
Topaz M, Motiei M, Gedanken A, Meyerstein D, Meyerstein N (2001) EPR analysis of radicals generated in ultrasound-assisted lipoplasty simulated environment. Ultrasound Med Biol 27:851–859
Klibanov AM, Martinek K, Berezin IV (1974) The effect of ultrasound on A-chymotrypsin, a new approach to the study of conformational changes (transitions) in the active centres of enzymes. Biokhimiya 39:878–887
Child SZ, Carstensen EL (1982) Effects of ultrasound on Drosophila — IV. Pulsed exposures of eggs. Ultrasound Med Biol 8:311–312
Child SZ, Hartman CL, Schery LA, Carstensen EL (1990) Lung damage from exposure to pulsed ultrasound. Ultrasound Med Biol 16:817–825
Tarantal AF, Canfield DR (1994) Ultrasound-induced lung hemorrhage in the monkey. Ultrasound Med Biol 20:65–72
Carstensen EL, Gracewski S, Dalecki D (2000) The search for cavitation in vivo. Ultrasound Med Biol 26:1377–1385
Frizzell LA, Zachary JF O’Brien WD Jr (2003) Effect of pulse polarity and energy on ultrasound-induced lung hemorrhage in adult rats. J Acoust Soc Am 113:2912–2918
Dalecki D, Raeman CH, Child SZ, Carstensen EL (1997) Effects of pulsed ultrasound on the frog heart: III. The radiation force mechanism. Ultrasound Med Biol 23:275–285
MacRobbie AG, Raeman CH, Child SZ, Dalecki D (1997) Thresholds for premature contractions in murine hearts exposed to pulsed ultrasound. Ultrasound Med Biol 23:761–765
Fowlkes JB, Holland CK (2000) Mechanical bioeffects from diagnostic ultrasound: AIUM consensus statements. J Ultrasound Med 19:69–72
Meltzer RS, Adsumelli R, Risher WH, Hicks GL Jr, Stern DH, Shah PM, Wojtczak JA, Lustik SJ, Gayeski TE, Shapiro JR, Carstensen EL (1998) Lack of lung hemorrhage in humans after intraoperative transesophageal echocardiography with ultrasound exposure conditions similar to those causing lung hemorrhage in laboratory animals. J Am Soc Echocardiogr 11:57–60
Miller DL, Thomas RM (1996) Contrast-agent gas bodies enhance hemolysis induced by lithotripter shock waves and high-intensity focused ultrasound in whole blood. Ultrasound Med Biol 22:1089–1095
Miller DL, Dou C (2004) Membrane damage thresholds for pulsed or continuous ultrasound in phagocytic cells loaded with contrast agent gas bodies. Ultrasound Med Biol 30:405–411
Li P, Armstrong WF Miller DL (2004) Impact of myocardial contrast echocardiography on vascular permeability: comparison of three different contrast agents. Ultrasound Med Biol 30:83–91
McIntosh IJC, Davey DA (1970) Chromosome aberrations induced by an ultrasonic fetal pulse detector. BMJ 4:92
Boyd E, Abdulla U, Donald I et al (1971) Chromosomal breakage and ultrasound. BMJ 2:501–502
Hill CR, Joshi GP, Revell SH (1972) A search for chromosome damage following exposure of Chinese hamster cells to high intensity pulsed ultrasound. Br J Radiol 45:333–334
McIntosh IJC, Brown RC, Coakley WT (1975) Ultrasound and ‘in-vitro’ chromosome aberrations. Br J Radiol 48:230–232
Liebeskind D, Bases R, Mendez R et al (1979) Sister chromatid exchanges in human lymphocytes after exposure to diagnostic ultrasound. Science 205:1273–1275
Ehlinger CA, Katayama PK, Roester MR et al (1979) Diagnostic ultrasound increases sister chromatid exchange, preliminary report. Wisc Med J 80:21–25
Brulfert A, Ciaravino V, Miller MW et al (1981) Diagnostic insonation of extra-utero human placenta: No effect of lymphocytic sister chromatid exchange. Hum Genet 66:289–291
Miller MW (1985) Does ultrasound induce sister chromatid exchanges? Ultrasound Med Biol 11:561–570
Carstensen EL, Gates AH (1984) The effects of pulsed ultrasound on the fetus. J Ultrasound Med 3:145–147
Manor SM, Serr DM, Tamari I et al (1972) The safety of ultrasound in fetal monitoring. Am J Obstet Gynecol 113:653–661
Lyon MF Simpson GM (1974) An investigation into the possible genetic hazards of ultrasound. Br J Radiol 47:712–722
Pizszarello DJ, Vivino A, Maden B et al (1978) Effect of pulsed low-power ultrasound on growing tissues. Expl Cell Biol 46:179–191
Stolzenberg S, Torbit CA, Edmonds PD et al (1980) Effects of ultrasound on the mouse exposed at different stages of gestation: Acute studies. Radiat Environ Biophys 17:245–270
Cevito KA (1976) Early postpartum mortality following ultrasound radiation. Ultrasound Med 2:535
Fry FJ, Erdmann WA, Johnson LK et al (1978) Ultrasound toxicity study. Ultrasound Med Biol 3:351–366
Sikov MR, Hildebrand BP (1979) Effects of prenatal exposure to ultrasound. In: Persaud TVN (ed) Advances in the study of birth defects, vol 2. MIT Press, Lancaster, p 267
Shimizu T, Shoji R (1973) An experimental Safety Study of Mice Exposed to Low-Intensity Ultrasound. Excerpta Medica International Series No. 227. Excerpta Medica, Amsterdam, p 28
Shoji R, Murakami U (1974) Further studies on the effect of ultrasound on mouse and rat embryos. Teratology 10:97–101
Murai N, Hoshi K, Kang C et al (1975) Effects of diagnostic ultrasound irradiation during foetal stage on emotional and cognitive behavior in rats. Tohoku J Exp Med 117:225–235
Kimmel C, Stratmeyer ME, Galloway WD et al (1983) An evaluation of the teratogenic potential of ultrasound exposure in pregnant ICR mice. Teratology 27:245–251
McClain RM, Hoar RM, Saltzman MB (1972) Teratology study of rats exposed to ultrasound. J Obstet Gynecol 14:39–42
Warwick R, Pond JB, Woodward B et al (1970) Hazards of diagnostic ultrasonography — a study with mice. IEEE Trans Sonics Ultrasonics Su-17:158
Edmonds PD (1979) Effects of ultrasound on biological structures. In: Hinselmann M, Anliker M, Mendt R (eds) Ultraschalldiagnostik in der Medizin. Thieme, Stuttgart, p 2
Brown N, Galloway WD, Henton WW (1981) Reflex development following in-utero exposure to ultrasound. In: Proceedings of the 26th Annual Meeting of American Institute of Ultrasound Medicine and 10th Annual Meeting of the Society of Diagnostic Medical Sonographers, Bethesda, MD, p 119
Salvesen KA, Eik-Nes SH (1995) Is ultrasound unsound? A review of epidemiological studies of human exposure to ultrasound. Ultrasound Obstet Gynecol 6:293–298
European Committee for Medical Ultrasound (1996) ECMUS Safety Committee Tutorial: Epidemiology of diagnostic ultrasound exposure during human pregnancy. EJU 4:69–73
Bernstein RL (1969) Safety studies with ultrasonic Doppler technique. Obstet Gynecol 34:707–709
Hellman LM, Duffus GM, Donald I et al (1970) Safety of diagnostic ultrasound in obstetrics. Lancet 1:1133–1134
Falus M, Koranyi G, Sobel M, Pests E, van Bao T (1972) Follow-up studies on infants examined by ultrasound during the fetal age. Orv Hetil 13:2119–2121
Ziskin MC (1972) Survey of patient exposure to diagnostic ultrasound. In: Reid JM, Sikov MR (eds) Interaction of ultrasound and biological tissues. DHEW (FDA) 78-8008. Government Printing Office, Washington DC
Scheidt PC, Stanley F, Bryla DA (1978) One year follow-up of infants exposed to ultrasound in utero. Am J Obstet Gynecol 131:743–748
Environmental Health Directorate (1981) Safety Code 23: Guidelines for the safe use of Ultrasound. Part I. Medical and paramedical applications, Report 8-EHD59. Ottawa Environmental Health Directorate, Health Protection Branch, Ottawa
Bakketeig L, Eik-Nes SH, Jacobsen G et al (1984) Randomised controlled trial of ultrasonographic screening in pregnancy. Lancet 2:207–211
Eik-Nes S, Okland O, Aure JC, Ulstein M (1984) Ultrasound screening in pregnancy: a randomised controlled trial. Lancet 2:1347
David H, Weaver JB, Pearson JF (1975) Doppler ultrasound and fetal activity. BMJ 2:62–64
Hertz RH, Timor-Tritsch I, Dierker LJ Jr et al (1979) Continuous ultrasound and fetal movement. Am J Obstet Gynecol 135:152–154
Powell-Phillips WD, Towell ME (1979) Doppler ultrasound and subjective assessment of fetal activity. BMJ 2:101–102
Murrills AJ, Barrington P, Harris PD, Wheeler T (1983) Influence of Doppler ultrasound on fetal activity. BMJ (Clip Res Ed) 286:1009–1012
Stark CR, Orleans M, Haverkamp AD et al (1984) Short and long term risks after exposure to diagnostic ultrasound in-utero. Obstet Gynecol 63:194–200
Lyons EA, Dyke C, Toms M, Cheang M (1988) In utero exposure to diagnostic ultrasound: a 6 year follow up. Radiology 166: 687–690
Moore RM Jr, Diamond EL, Cavaliers RL (1988) The relationship of birth weight and intrauterine diagnostic ultrasound exposure. Obstet Gynecol 71:513–517
Waldenstrom U, Axelsson O, Nilsson S et al (1988) Effects of routine one-stage ultrasound screening in pregnancy: a randomised controlled trial. Lancet 2:585–588
Newnham JP, Evans SF, Michael CA et al (1993) Effects of frequent ultrasound during pregnancy: a randomised controlled trial. Lancet 342:887–891
Ewigman B, Crane JP, Frigoletto FD et al (1993) Effect of prenatal ultrasound screening on perinatal outcome. N Engl J Med 329:821–827
Salvesen KA, Jacobsen G, Vatten LJ et al (1993) Routine ultrasonography in utero and subsequent growth during childhood. Ultrasound Obstet Gynecol 3:6–10
Grisso JA, Strom BL, Cosmatos I et al (1994) Diagnostic ultrasound in pregnancy and low birthweight. Am J Perinatol 11:297–301
Macdonald W, Newnham J, Gurrin L, Evans S (1996) Effect of frequent prenatal ultrasound on birthweight: follow up at 1 year of age. Western Australian Pregnancy Cohort (Raine) Working Group. Lancet 348:482
Neilson JP (2004) Ultrasound for fetal assessment in early pregnancy (Cochrane Review). In: The Cochrane Library, Issue 2. John Wiley & Sons, Ltd, Chichester, UK
Kinnier-Wilson LM, Waterhouse J (1984) Obstetric ultrasound and childhood malignancies. Lancet 2:997–999
Sorahan T, Lancashire R, Stewart A, Peck I (1995) Pregnancy ultrasound and childhood cancer: a second report from the Oxford Survey of Childhood Cancers. Br J Obstet Gynaecol 102: 831–832
Cartwright R, McKinney PA, Hopton PA et al (1984) Ultrasound examination in pregnancy and childhood cancer. Lancet 2:999–1000
Shu X, Jin F, Linet MS et al (1994) Diagnostic x-ray and ultrasound exposure and risk of childhood cancer. Br J Cancer 70: 531–536
Naumburg E, Bellocco R, Cnattingius S et al (2000) Prenatal ultrasound examinations and risk of childhood leukaemia: case-control study. BMJ 320:282–283
Salvesen KA, Bakketeig LS, Eik-nes SH et al (1992) Routine ultrasonography in utero and school performance at age 8–9 years. Lancet 339:85–89
Campbell JD, Elford RW, Brant RF (1993) Case-control study of prenatal ultrasonography exposure in children with delayed speech. CMAJ 149:1435–1440
Salvesen KA, Vatten LJ, Bakketeig LS, Eik-Nes SH (1994) Routine ultrasonography in utero and speech development. Ultrasound Obstet Gynecol 4:101–103
Kieler H, Ahlsten G, Haglund B et al (1998) Routine ultrasound screening in pregnancy and the children’s subsequent neurologic development. Obstet Gynecol 91:750–756
Salvesen KA, Vatten LJ, Eik-Nes SH, Hugdahl K, Bakketeig LS (1993) Routine ultrasonography in utero and subsequent handedness and neurological development. BMJ 307:159–164
Kieler H, Axelsson O, Haglund B, Nilsson S, Salvesen KA (1998) Routine ultrasound screening in pregnancy and the children’s subsequent handedness. Early Hum Dev 50:233–245
Kieler H, Cnattingius S, Haglund B, Palmgren J, Axelsson O (2001) Sinistrality — a side-effect of prenatal sonography: a comparative study of young men. Epidemiology 12:618–623
AIUM (1995) Conclusions Regarding Epidemiology
Haar GT (1997) Commentary: Safety of diagnostic ultrasound. Br J Radiol 69:1083–1085
Suslick K (1989) The Chemical Effects of Ultrasound. Sci Am 260:80–86
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Maulik, D. (2005). Biological Safety of Diagnostic Sonography. In: Maulik, D. (eds) Doppler Ultrasound in Obstetrics and Gynecology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28903-8_8
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