Skip to main content

Pretargeted Radioimmunotherapy

  • Conference paper
Molecular Imaging

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 49))

  • 972 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Barba D, Saris SC, Holder C, Rosenberg SA, Oldfield EH (1989) Intratu-moral LAK cell and interleukin-2 therapy of human glioma. J Neurosurg 70:175–182

    Article  PubMed  CAS  Google Scholar 

  • Boiardi A, Salmaggi A, Pozzi A, Broggi G, Silvani A (1996) Interstitial chemotherapy with mitoxantrone in recurrent malignant glioma: preliminary data. J Neurooncol 27:157–162

    Article  PubMed  CAS  Google Scholar 

  • Bos ES, Kuijpers WHA, Meesters-Winters M, Pham DT, de Haan AS, van Doornmalen AM, Kaspersen FM, van Boeckel CAA, Gougeoun-Bertrand F (1994) In vitro evaluation of DNA-DNA hybridization as a two step approach in radioimmunotherapy of cancer. Cancer Res 54:3479–3486

    PubMed  CAS  Google Scholar 

  • Buraggi GL, Callegaro L, Mariani G, Turrin A, Cascinelli N, Attili A, Bom-bardieri E, Terno G, Plassio G, Dovis M (1985) Imaging with 131I-labeled monoclonal antibodies to a high-molecular-weight melanoma-associated antigen in patients with melanoma: Efficacy of whole immunoglobulin and its F(ab’)2 fragments. Cancer Res 45:3378–3387

    PubMed  CAS  Google Scholar 

  • Chetanneau A, Barbet J, Peltier P, Le-Doussal JM, Gruaz-Guyon A, Bernard AM, Resche I, Rouvier E, Bourguet P, Delaage M (1994) Pretargeted imaging of colorectal cancer recurrences using an In-111-labelled bivalent hapten and a biospecific antibody conjugate. Nucl Med Commun 15:972–980

    PubMed  CAS  Google Scholar 

  • Chinol M, Hnatowich DJ (1987) Generator-produced yttrium-90 for radioimmunotherapy. J Nucl Med 28:1465–1470

    PubMed  CAS  Google Scholar 

  • Cokgor I, Akabani G, Kuan CT, Friedman HS, Friedman HA, Coleman RE, McLendon RE, Bigner SH, Zhao XG, Garcia-Turner AM, Pegram CN, Wikstrand CJ, Shafman TD, Herndon JE 2nd, Provenzale JM, Zalutsky MR, Bigner DD (2000) Phase I Trial Results of Iodine-131-labeled antitenascin monoclonal antibody 81c6 treatment of patients with newly diagnosed malignant gliomas. J Clin Oncol 18:3862–3872

    PubMed  CAS  Google Scholar 

  • De Jong M, Valkema R, Jamar F, Kvols LK, Kwekkeboom DJ, Breeman WA, Bakker WH, Smith C, Pauwels S, Krenning EP (2002) Somatostatin receptor-targeted radionuclide therapy of tumors: preclinical and clinical findings. Semin Nucl Med 32:133–140

    Article  PubMed  Google Scholar 

  • Epenetos AA, Munro AJ, Stewart JSW, Rampling R, Lambert HE, McKenzie CG, Soutter WP, Rahemtulla A, Hooker G, Sivolapenko G, Snook D, Courtenay-Luck N, Dhokia B, Krausz T, Taylor-Papadimitriou J, Durbin H, Bodmer WF (1987) Antibody-guided irradiation of advanced ovarian cancer with intraperitoneally administered radiolabelled monoclonal antibodies. J Clin Oncol 5:1890–1899

    PubMed  CAS  Google Scholar 

  • Fazio F, Paganelli G (1993) Antibody-guided scintigraphy: targeting of the “magic bullet. Eur J Nucl Med 20:1138–1140

    Article  PubMed  CAS  Google Scholar 

  • Goodwin DA, Meares CF, McCall MJ, McTigue M, Chaovapong W (1988) Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens. J Nucl Med 29:226–234

    PubMed  CAS  Google Scholar 

  • Grana C, Chinol M, Robertson C, Mazzetta C, Bartolomei M, De Cicco C, Fiorenza M, Gatti M, Caliceti P, Paganelli G (2002) Pretargeted adjuvant radioimmunotherapy with yttrium-90-biotin in malignant glioma patients: a pilot study. Br J Cancer 86:207–212

    Article  PubMed  CAS  Google Scholar 

  • Green NM (1963) Avidin-1. The use of [14C] biotin for kinetic studies and for assay. Biochem J 89:585–591

    PubMed  CAS  Google Scholar 

  • Hamilton TC, Ozols RF, Longo DL (1987) Biologic therapy for the treatment of malignant common epithelial tumors of the ovary. Cancer 60[Suppl 8]:2054–2063

    PubMed  CAS  Google Scholar 

  • Hazra DK, Britton KE, Lahiri VL, Gupta AK, Khanna P, Saran S (1995) Immunotechnological trend in radioimmuno-targeting: from “magic bullet” to “smart bomb”. Nucl Med Commun 16:66–75

    Article  PubMed  CAS  Google Scholar 

  • Hirai H (1990) Use of tumor receptors for diagnostic imaging. Acta Radiol 374:57–64

    CAS  Google Scholar 

  • Hopkins K, Chandler C, Bullimore J, Sandeman D, Coakham H, Kemshead JT (1995) A pilot study of the treatment of patients with recurrent malignant gliomas with intratumoral yttrium-90 radioimmunoconjugates. Radiother Oncol 34:121–131

    Article  PubMed  CAS  Google Scholar 

  • Jain RK (1991) Haemodynamic and transport barriers to the treatment of solid tumors. Int J Radiat Bid 60:85–100

    Article  CAS  Google Scholar 

  • Johnson DA, Baker AL, Laguzza BC, Fix DV, Gutowski MC (1990) Anti-tumor activity of L/1C2-4-desacetylvinblastine-3-carboxyhydrazide im-munoconjugate in xenografts. Cancer Res 50:1790–1794

    PubMed  CAS  Google Scholar 

  • Kim JA, Triozzi PL, Martin EW (1993) Radioimmunoguided surgery for colorectal cancer. Oncology 7:55–60

    PubMed  Google Scholar 

  • Kuhn JA, Corbisiero RM, Buras RR, Carroll RG, Wagman LD, Wilson LA, Yamauchi D, Smith MM, Kondo R, Beatty D (1991) Intraoperative gamma detection probe with presurgical antibody imaging in colon cancer. Arch Surg 126:1398–1403

    PubMed  CAS  Google Scholar 

  • Larson SM (1985) Radiolabelled monoclonal anti-tumor antibodies and therapy. J Nucl Med 26:538–545

    PubMed  CAS  Google Scholar 

  • LeDoussal JM, Martin M, Gautherot E, Delaage M, Barbet J (1989) In vitro and in vivo targeting of radiolabeled monovalent and divalent haptens with dual specificity monoclonal antibody conjugates: enhanced divalent hapten affinity for cell-bound antibody conjugate. J Nucl Med 30:1358–1366

    CAS  Google Scholar 

  • Leichner PK, Koral KF, Jaszczak RJ, Green AJ, Chen GTY, Roeske JC (1993) An overview of imaging techniques and physical aspects of treatment planning in radioimmunotherapy. Med Physics 20:569–577

    Article  CAS  Google Scholar 

  • Magnani P, Paganelli G, Modorati G, Zito F, Songini C, Sudati F, Koch P, Maecke HR, Brancato R, Siccardi AG, Fazio F (1996) Quantitative comparison of direct antibody labeling and tumor pretargeting in uveal melanoma. J Nucl Med 37:967–971

    PubMed  CAS  Google Scholar 

  • Mann BD, Cohen MB, Saxton RE, Morton DL, Benedict WF, Korn EL, Spolter L, Graham LS, Chang CC, Burk MW (1984) Imaging of human tumor xenografts in nude mice with radiolabeled monoclonal antibodies. Limitations of specificity due to nonspecific uptake of antibody. Cancer 54:1318–1327

    Article  PubMed  CAS  Google Scholar 

  • Paganelli G, Riva P, Deleide G, Clivio A, Chiolerio F, Scasselati GA, Mal-covati M, Siccardi AG (1988) In vivo labelling of biotinylated monoclonal antibodies by radioactive avidin: a strategy to increase tumor radiolocalization. Int J Cancer 2:121–125

    Article  CAS  Google Scholar 

  • Paganelli G, Magnani P, Zito F, Villa S, Sudati F, Lopalco L, Rossetti C, Malcovati M, Chiolerio F, Seccamani E, Siccardi AG, Fazio F (1991a) Three-step monoclonal antibody tumor targeting in carcinoembryonic antigen-positive patients. Cancer Res 51:5960–5966

    PubMed  CAS  Google Scholar 

  • Paganelli G, Malcovati M, Fazio F (1991b) Monoclonal antibody pretargetting techniques for tumor localization: the avidin-biotin system. Nucl Med Commun 12:211–234

    Article  PubMed  CAS  Google Scholar 

  • Paganelli G, Belloni C, Magnani P, Zito F, Pasini A, Sassi I, Meroni M, Mariani M, Vignali M, Siccardi AG, Fazio F (1992) Two-step tumor targeting in ovarian cancer patients using biotinylated monoclonal antibodies and radioactive streptavidin. Eur J Nucl Med 19:322–329

    Article  PubMed  CAS  Google Scholar 

  • Paganelli G, Grana C, Chinol M, Cremonesi M, De Cicco C, De Braud F, Robertson C, Zurrida S, Casadio C, Zoboli S, Siccardi AG, Veronesi U (1999) Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin. Eur J Nucl Med 26:348–357

    Article  PubMed  CAS  Google Scholar 

  • Paganelli G, Bartolomei M, Ferrari M, Cremonesi M, Broggi G, Maira G, Sturiale C, Grana C, Prisco G, Gatti M, Caliceti P, Chinol M (2001) Pretargeted locoregional radioimmunotherapy with 90Y-biotin in glioma patients: phase I study and preliminary therapeutic results. Cancer Biother Radiopharm 16:227–235

    Article  PubMed  CAS  Google Scholar 

  • Rand RW, Kreitman RJ, Patronas N, Varricchio F, Pastan I, Puri RK (2000) Intratumoral administration of recombinant circulary permuted interleukin-4-Pseudomonas Exotoxin in patients with high-grade glioma. Clin Cancer Res 6:2157–2165

    PubMed  CAS  Google Scholar 

  • Riva P, Franceschi G, Frattarelli M, et al. (1999) Loco-regional radioimmunotherapy of high-grade malignant gliomas using specific monoclonal antibodies labeled with 90Y: a Phase I study. Clin Cancer Res 5[Suppl 10]: 3275s–3280s

    PubMed  CAS  Google Scholar 

  • Schlom J (1986) Basic principles and application of monoclonal antibodies in the management of carcinomas: the Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res 46:3225–3238

    PubMed  CAS  Google Scholar 

  • Strand SE, Zanzonico P, Johnson TK (1993) Pharmacokinetic modeling. Med Physics 20:515–527

    Article  CAS  Google Scholar 

  • Sung C, van Osdol WW (1995) Pharmacokinetic comparison of direct antibody targeting with pretargeting protocols based on streptavidin-biotin binding. J Nucl Med 36:867–876

    PubMed  CAS  Google Scholar 

  • Wawrzynczak EJ (1991) Systemic immunotoxin therapy of cancer: advances and prospects. Br J Cancer 64:624–630

    PubMed  CAS  Google Scholar 

  • Wessels BW, Rogus RD (1984) Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies. Med Phys 11:638–645

    Article  PubMed  CAS  Google Scholar 

  • Wilchek M, Bayer EA (1984) The avidin biotin complex in immunology. Immunol Today 5:39–43

    Article  CAS  Google Scholar 

  • Wilchek M, Bayer EA (1988) The avidin biotin complex in bioanalytical applications. Anal Biochem 171:1–32

    Article  PubMed  CAS  Google Scholar 

  • Zagzag D, Friedlander DR, Dosik J, Chikramane S, Chan W, Greco MA, Allen JC, Dorovini-Zis K, Grumet M (1996) Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro. Cancer Res 56:182–189

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Paganelli, G. (2005). Pretargeted Radioimmunotherapy. In: Bogdanov, A.A., Licha, K. (eds) Molecular Imaging. Ernst Schering Research Foundation Workshop, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26809-X_4

Download citation

  • DOI: https://doi.org/10.1007/3-540-26809-X_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-21021-4

  • Online ISBN: 978-3-540-26809-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics