Skip to main content

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bader CR, Macleish PR, Schwartz EA (1979) A voltage-clamp study of the light response in solitary rods of the tiger salamander. J Physiol 296: 1–26

    CAS  PubMed  Google Scholar 

  • Bal T, McCormick DA (1996) What stops synchronized thalamocortical oscillations? Neuron 17: 297–308

    Article  CAS  PubMed  Google Scholar 

  • Bois P, Bescond J, Renaudon B, Lenfant J (1996) Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Br J Pharmacol 118: 1051–1057

    CAS  PubMed  Google Scholar 

  • Borer JS, Fox K, Jaillon P, Lerebours G (2003) Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial. Circulation 107: 817–823

    Article  PubMed  Google Scholar 

  • Brown H, Difrancesco D (1980) Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node. J Physiol 308: 331–351

    CAS  PubMed  Google Scholar 

  • Bucchi A, Baruscotti M, DiFrancesco D (2002) Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine. J Gen Physiol 120: 1–13

    Article  CAS  PubMed  Google Scholar 

  • Cerbai E, Barbieri M, Mugelli A (1994) Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes isolated from hypertensive rats. J Physiol 481 (Pt 3): 585–591

    CAS  PubMed  Google Scholar 

  • Chen S, Wang J, Siegelbaum SA (2001) Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. J Gen Physiol 117: 491–504

    CAS  PubMed  Google Scholar 

  • DiFrancesco D (1982) Block and activation of the pace-maker channel in calf purkinje fibres: effects of potassium, caesium and rubidium. J Physiol 329: 485–507

    CAS  PubMed  Google Scholar 

  • DiFrancesco D (1994) Some properties of the UL-FS 49 block of the hyperpolarization-activated current (i(f)) in sinoatrial node myocytes. Pflugers Arch 427: 64–70

    Article  CAS  PubMed  Google Scholar 

  • Er F, Larbig R, Ludwig A, Biel M, Hofmann F, Beuckelmann DJ, Hoppe UC (2003) Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes. Circulation 107: 485–489

    Article  PubMed  Google Scholar 

  • Gauss R, Seifert R (2000) Pacemaker oscillations in heart and brain: a key role for hyperpolarization-activated cation channels. Chronobiol Int 17: 453–469

    Article  CAS  PubMed  Google Scholar 

  • Hoppe UC, Beuckelmann DJ (1998) Characterization of the hyperpolarization-activated inward current in isolated human atrial myocytes. Cardiovasc Res 38: 788–801

    Article  CAS  PubMed  Google Scholar 

  • Hoppe UC, Jansen E, Sudkamp M, Beuckelmann DJ (1998) Hyperpolarization-activated inward current in ventricular myocytes from normal and failing human hearts. Circulation 97: 55–65

    CAS  PubMed  Google Scholar 

  • Kokubun S, Nishimura M, Noma A and Irisawa H (1982) Membrane currents in the rabbit atrioventricular node cell. Pflugers Arch 393: 15–22

    Article  CAS  PubMed  Google Scholar 

  • Ludwig A, Budde T, Stieber J et al. (2003) Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. Embo J 22: 216–224

    CAS  PubMed  Google Scholar 

  • Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M (1998) A family of hyperpolarization-activated mammalian cation channels. Nature 393: 587–591

    CAS  PubMed  Google Scholar 

  • Maruoka F, Nakashima Y, Takano M, Ono K, Noma A (1994) Cation-dependent gating of the hyperpolarization-activated cation current in the rabbit sino-atrial node cells. J Physiol 477 (Pt 3): 423–435

    CAS  PubMed  Google Scholar 

  • Moosmang S, Biel M, Hofmann F, Ludwig A (1999) Differential distribution of four hyperpolarization-activated cation channels in mouse brain. Biol Chem 380: 975–980

    Article  CAS  PubMed  Google Scholar 

  • Santoro B, Grant SG, Bartsch D, Kandel ER (1997) Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci USA 94: 14815–14820

    CAS  PubMed  Google Scholar 

  • Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D (2003) Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest 111: 1537–1545

    Article  CAS  PubMed  Google Scholar 

  • Seifert R, Scholten A, Gauss R, Mincheva A, Lichter P, Kaupp UB (1999) Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci USA 96: 9391–9396

    Article  CAS  PubMed  Google Scholar 

  • Shi W, Wymore R, Yu H, Wu J, Wymore RT, Pan Z, Robinson RB, Dixon JE, McKinnon D, Cohen IS (1999) Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res 85: e1–6

    CAS  PubMed  Google Scholar 

  • Ulens C, Tytgat J (2001) Functional heteromerization of HCN1 and HCN2 pacemaker channels. J Biol Chem 276: 6069–6072

    Article  CAS  PubMed  Google Scholar 

  • Van Bogaert PP, Goethals M (1987) Pharmacological influence of specific bradycardic agents on the pacemaker current of sheep cardiac Purkinje fibres. A comparison between three different molecules. Eur Heart J 8[Suppll]: 35–42

    PubMed  Google Scholar 

  • Vassalle M, Yu H, Cohen IS (1995) The pacemaker current in cardiac Purkinje myocytes. J Gen Physiol 106: 559–578

    Article  CAS  PubMed  Google Scholar 

  • Yanagihara K, Irisawa H (1980) Inward current activated during hyperpolarization in the rabbit sinoatrial node cell. Pflugers Arch 385: 11–19

    Article  CAS  PubMed  Google Scholar 

  • Yu H, Chang F, Cohen IS (1993) Pacemaker current exists in ventricular myocytes. Circ Res 72: 232–236

    CAS  PubMed  Google Scholar 

  • Yu H, Wu J, Potapova I et al. (2001) MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circ Res 88: E84–87

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hoppe, U.C., Er, F., Brandt, M.C. (2005). Recording the Pacemaker Current If. In: Dhein, S., Mohr, F.W., Delmar, M. (eds) Practical Methods in Cardiovascular Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26574-0_19

Download citation

  • DOI: https://doi.org/10.1007/3-540-26574-0_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40763-8

  • Online ISBN: 978-3-540-26574-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics