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Imaging Endocrine Diseases in Children

The Evaluation of Normal and Abnormal Bone Growth: Including Skeletal Involvement in Endocrine Diseases

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Imaging Endocrine Diseases in Children

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

The role of skeletal imaging in cases of suspected endocrine disease is to detect, and possibly quantify, any bone involvement to secure a correct diagnosis, to search for complications to treatment and to guide further management. Growing bone is challenging, as bone structure, shape and size changes continuously until skeletal maturity. The numerous normal variants of growth which may mimic pathology have been accurately described radiographically, but little is known about the appearances on magnetic resonance imaging (MRI). Thus, radiography remains an important method with a high specificity for a number of diseases through “pattern recognition”. Its low sensitivity for cartilage, bone marrow and soft tissue involvement, however, has opened the way for additional techniques, such as ultrasound, MRI, computed tomography (CT) and nuclear imaging.

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References

  • American college of rheumatology Atlanta G. practice guidelines, Atlanta (2005): http://www.rheumatology.org/publications/guidelines/index.asp?aud=mem

  • Bastepe M (2008) The GNAS locus and pseudohypoparathyroidism. Adv Exp Med Biol 626:27–40

    Article  PubMed  CAS  Google Scholar 

  • Binkovitz LA, Henwood MJ (2007) Pediatric DXA: technique and interpretation. Pediatr Radiol 37(1):21–31

    Article  PubMed  Google Scholar 

  • Binkovitz LA, Sparke P, Henwood MJ (2007) Pediatric DXA: clinical applications. Pediatr Radiol 37(7):625–635

    Google Scholar 

  • Birrell G, Cheetham T (2004) Juvenile thyrotoxicosis; can we do better? Arch Dis Child 89(8):745–750 Aug 2004

    Google Scholar 

  • Blumer MJ, Longato S, Fritsch H (2008) Structure, formation and role of cartilage canals in the developing bone. Ann Anat 190(4):305–315

    Article  PubMed  Google Scholar 

  • Brenner AI, Koshy J, Morey J, Lin C, Dipoce J (2012) The bone scan. Semin Nucl Med 42(1):11–26

    Google Scholar 

  • Consensus Development Conference (2004) Diagnosis of osteoporosis in men, premenopausal women, and children. J Clin Densitom 7(1):17–26

    Article  Google Scholar 

  • Cromer BA, Binkovitz L, Ziegler J, Harvey R, Debanne SM (2004) Reference values for bone mineral density in 12–18-year-old girls categorized by weight, race, and age. Pediatr Radiol 34(10):787–792

    Article  PubMed  Google Scholar 

  • Donoghue V, Twomey EL Huda W (2005) Radiation dose and image quality. In: Carty H, Brunelle F, Stringer DA, Kao SCS. (Eds) Imaging children, 2nd edn. Elsevier, Churchill Livingstone, Edinburgh

    Google Scholar 

  • Ellis KJ, Shypailo RJ, Hardin DS, Perez MD, Motil KJ, Wong WW et al. (2001) Z score prediction model for assessment of bone mineral content in pediatric diseases. J Bone Miner Res. 16(9):1658–1664

    Article  PubMed  CAS  Google Scholar 

  • Gartner LP, Hiatt J (2001) Color textbook of histology, 2nd edn. Saunders Company, Philadelphia

    Google Scholar 

  • Jaramillo D, Laor T, Hoffer FA, Zaleske DJ, Cleveland RH, Buchbinder BR et al (1991) Epiphyseal marrow in infancy: MR imaging. Radiology 180(3):809–812

    PubMed  CAS  Google Scholar 

  • Jones K (1997) Smiths recognizable patterns of human malformation, 5th edn. WB Saunders, Philadelphia

    Google Scholar 

  • Kollars J, Zarroug AE (2005) van HJ, Lteif A, Stavlo P, Suarez L et al. Primary hyperparathyroidism in pediatric patients. Pediatrics 115(4):974–980

    Google Scholar 

  • Kooh SW, Brnjac L, Ehrlich RM, Qureshi R, Krishnan S (1996) Bone mass in children with congenital hypothyroidism treated with thyroxine since birth. J Pediatr Endocrinol Metab 9(1):59–62

    Article  PubMed  CAS  Google Scholar 

  • Kuhns LR, Finnstrom O (1976) New standards of ossification of the newborn. Radiology 119(3):655–660

    PubMed  CAS  Google Scholar 

  • LaFranchi S (1987) Diagnosis and treatment of hypothyroidism in children. Compr Ther 13(10):20–30

    PubMed  CAS  Google Scholar 

  • Laor T, Jaramillo D (2009) MR imaging insights into skeletal maturation: what is normal? Radiology 250(1):28–38

    Google Scholar 

  • Link T (2011) Cartilage imaging: significance, techniques, and new developments. New York, Springer

    Google Scholar 

  • Martin DD, Heckmann C, Jenni OG, Ranke MB, Binder G, Thodberg HH (2011) Metacarpal thickness, width, length and medullary diameter in children—reference curves from the first Zurich Longitudinal Study. Osteoporos Int 22(5):1525–1536

    Article  PubMed  CAS  Google Scholar 

  • Martin DD, Wit JM, Hochberg Z, Savendahl L, van Rijn RR, Fricke O et al (2011) The use of bone age in clinical practice—Part 1. Horm Res Paediatr 76(1):1–9

    Article  PubMed  CAS  Google Scholar 

  • Moore SG, Dawson KL (1990) Red and yellow marrow in the femur: age-related changes in appearance at MR imaging. Radiology 175(1):219–223

    PubMed  CAS  Google Scholar 

  • Mora S, Weber G, Marenzi K, Signorini E, Rovelli R, Proverbio MC et al (1999) Longitudinal changes of bone density and bone resorption in hyperthyroid girls during treatment. J Bone Miner Res 14(11):1971–1977

    Article  PubMed  CAS  Google Scholar 

  • Muller LS, Avenarius D, Damasio B, Eldevik OP, Malattia C, Lambot-Juhan K et al (2010) The paediatric wrist revisited: redefining MR findings in healthy children. Ann Rheum Dis 70(4):605–610

    Article  PubMed  Google Scholar 

  • Murphy E, Williams GR (2004) The thyroid and the skeleton Clin Endocrinol (Oxf) 61(3):285–298

    Article  CAS  Google Scholar 

  • Oestreich AE (2008) Growth of the Pediatric Skeleton. Springer, Berlin

    Google Scholar 

  • Pyle SI, Waterhouse AM, Greulich WW (1971) Attributes of the radiographic standard of reference for the National Health Examination Survey. Am J Phys Anthropol 35(3):331–337

    Article  PubMed  CAS  Google Scholar 

  • Rastogi MV, LaFranchi SH (2010) Congenital hypothyroidism. Orphanet J Rare Dis vol 5: p 17

    Article  PubMed  Google Scholar 

  • Rivkees SA, Bode HH, Crawford JD (1988) Long-term growth in juvenile acquired hypothyroidism: the failure to achieve normal adult stature. N Engl J Med 318(10):599–602

    Article  PubMed  CAS  Google Scholar 

  • Rockwood and Wilkins’ (2010) Fractures in children, 7th edn. Lippincott Williams and Wilkins, Philadelphia

    Google Scholar 

  • Savage MO, Chan LF, Grossman AB, Storr HL (2008) Work-up and management of paediatric Cushing’s syndrome. Curr Opin Endocrinol Diabetes Obes 15(4):346–351

    Article  PubMed  Google Scholar 

  • Schmeling A, Baumann U, Schmidt S, Wernecke KD, Reisinger W (2006) Reference data for the Thiemann-Nitz method of assessing skeletal age for the purpose of forensic age estimation. Int J Legal Med 120(1):1–4

    Article  PubMed  Google Scholar 

  • Schmitt R, Lanz U (2008) Diagnostic Imaging of the Hand. Thieme Publishing Group, Stuttgart

    Google Scholar 

  • Schumacher R, Seaver L, Spranger J (2004) Fetal radiology. A diagnostic atlas. Springer, Berlin

    Google Scholar 

  • Segni M, Gorman CA (2001) The aftermath of childhood hyperthyroidism. J Pediatr Endocrinol Metab 14(5):1277–1282

    PubMed  Google Scholar 

  • Tanner J, Healty M (2001) GH Assessment of skeletal maturity and prediction of adult height (TW3 method) Saunders, London

    Google Scholar 

  • Thodberg HH, Kreiborg S, Juul A, Pedersen KD (2009) The BoneXpert method for automated determination of skeletal maturity. IEEE Trans Med Imaging 28(1):52–66

    Article  PubMed  Google Scholar 

  • Thodberg HH, Neuhof J, Ranke MB, Jenni OG, Martin DD (2010) Validation of bone age methods by their ability to predict adult height. Horm Res Paediatr 74(1):15–22

    Article  PubMed  CAS  Google Scholar 

  • Thodberg HH, Savendahl L (2010) Validation and reference values of automated bone age determination for four ethnicities. Acad Radiol 17(11):1425–1432

    Article  PubMed  Google Scholar 

  • Weise M, De-Levi S, Barnes KM, Gafni RI, Abad V, Baron J (2001) Effects of estrogen on growth plate senescence and epiphyseal fusion Proc Natl Acad Sci U S A 98(12):6871–6876

    Google Scholar 

  • Winer KK, Sinaii N, Reynolds J, Peterson D, Dowdy K, Cutler GB Jr (2010) Long-term treatment of 12 children with chronic hypoparathyroidism: a randomized trial comparing synthetic human parathyroid hormone 1–34 versus calcitriol and calcium. J Clin Endocrinol Metab 95(6):2680–2688

    Article  PubMed  CAS  Google Scholar 

  • Yasuda T, Niimi H (1997) Hypoparathyroidism and pseudohypoparathyroidism. Acta Paediatr Jpn 39(4):485–490

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

I am very grateful to Illustrator Ellinor Moldeklev Hoff, Department of Photo and Drawing, University of Bergen, for providing the drawings, and to Prof. Paolo Toma and Dr. Domenico Barbuti, Diagnostic imaging, both OPBG, Rome and Dr. Veronica Donoghue, Children’s University Hospital, Dublin, for providing some of the images.

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Authors and Affiliations

  1. Department of Paediatric Radiology, Haukeland University Hospital, 5021, Bergen, Norway

    K. Rosendahl

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  1. K. Rosendahl
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Correspondence to K. Rosendahl .

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Editors and Affiliations

  1. , Department of pediatric imaging, Jeanne de Flandres Hospital, Rue Oscar Lambret 2, CHRU-Lille, 59000, France

    Fred Avni

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© 2012 Springer-Verlag Berlin Heidelberg

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Rosendahl, K. (2012). Imaging Endocrine Diseases in Children. In: Avni, F. (eds) Imaging Endocrine Diseases in Children. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_590

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  • DOI: https://doi.org/10.1007/174_2012_590

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-20702-0

  • Online ISBN: 978-3-642-20703-7

  • eBook Packages: MedicineMedicine (R0)

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