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Brain Tumors

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Re-irradiation: New Frontiers

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Historically radiation oncologists have been cautious about re-irradiating brain tumours because of concerns about the risks of late central nervous system toxicity, especially radionecrosis, which may occur several months to years after treatment. There is, however, a lack of prospective data addressing this approach. Re-irradiation of brain tumours is attracting more interest as our understanding of the tolerance of the brain to radiation evolves, and developments in radiation technology and imaging make highly accurate targeting of biologically relevant tumour volumes possible. With developments in molecular-targeted therapy, further exploration of the role of re-irradiation on its own or in combination with novel agents is needed.

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Authors and Affiliations

  1. University College Hospital, 1st Floor East, 250 Euston Road, London, NW1 2PG, UK

    Jennifer E. Gains

  2. UCL Cancer Institute, 72 Huntley Street, London, WC1E 6BT, UK

    Susan C. Short

Authors
  1. Jennifer E. Gains
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  2. Susan C. Short
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Correspondence to Jennifer E. Gains .

Editor information

Editors and Affiliations

  1. , Dept. Internal Medicine, Nordlandssykehuset HF, Prinsensgate 164, Bodoe, 8092, Norway

    Carsten Nieder

  2. Department of Radiation Oncology, University Medical Center Groningen, Hanzeplein 1, Groningen, 9700 RB, Netherlands

    Johannes A. Langendijk

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© 2010 Springer-Verlag Berlin Heidelberg

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Gains, J.E., Short, S.C. (2010). Brain Tumors. In: Nieder, C., Langendijk, J. (eds) Re-irradiation: New Frontiers. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_68

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  • DOI: https://doi.org/10.1007/174_2010_68

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12467-9

  • Online ISBN: 978-3-642-12468-6

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